Findings of Scientific Misconduct, 33308-33309 [06-5204]

Download as PDF 33308 PLACE: Federal Register / Vol. 71, No. 110 / Thursday, June 8, 2006 / Notices 999 E Street, NW., Washington, DC. This meeting will be closed to the public. ITEMS TO BE DISCUSSED: Compliance matters pursuant to 2 U.S.C. 437g. Audits conducted pursuant to 2 U.S.C. 437g, 438g, 438(b), and Title 26, U.S.C. Matters concerning participation in civil actions or proceedings or arbitration. Internal personnel rules and procedures or matters affecting a particular employee. * * * * * PERSON TO CONTACT FOR INFORMATION: Mr. Robert Biersack, Press Officer. Telephone: (202) 694–1220. STATUS: Mary W. Dove, Secretary of the Commission. [FR Doc. 06–5274 Filed 6–6–06; 2:30 pm] GENERAL SERVICES ADMINISTRATION [FMR Bulletin 2006–B4] Federal Management Regulation; Federal Real Property Profile Summary Report General Services Administration. ACTION: Notice. cprice-sewell on PROD1PC66 with NOTICES AGENCY: SUMMARY: In furtherance of FMR Bulletin 2005–B4, this notice announces the FY 2005 release of the new version of the Federal Real Property Profile (FRPP) Summary Report, which provides an overview of the U.S. Government’s owned and leased real property as of September 30, 2005. The FY 2005 FRPP Summary Report is now available. EFFECTIVE DATE: June 8, 2006. FOR FURTHER INFORMATION CONTACT For clarification of content, contact Stanley C. Langfeld, Director, Regulations Management Division (MPR), General Services Administration, Washington, DC 20405; stanley.langfeld@gsa.gov, (202) 501–1737. Please cite FMR Bulletin 2006–B4. SUPPLEMENTARY INFORMATION: The FY 2005 FRPP Summary Report is a summary of the Government’s real property assets as generated by the FRPP inventory system which was recently enhanced and modified in response to the Federal Real Property Council’s (FRPC) requirements. GSA partnered with numerous Federal agencies and the FRPC to develop and 15:37 Jun 07, 2006 Jkt 208001 Dated: June 1, 2006. John G. Sindelar, Acting Associate Administrator, Office of Governmentwide Policy. General Services Administration [FMR Bulletin 2006–B4] BILLING CODE 6715–01–M VerDate Aug<31>2005 manage a centralized, comprehensive, and descriptive database of the Government’s real property portfolio. GSA, in collaboration with the FRPC, determined that enhancing the existing FRPP with numerous modifications and upgrades was the most cost-effective, efficient solution. The goals of the centralized database are to 1) improve decision-making with more accurate and reliable data; 2) provide the ability to benchmark Federal real property assets; and 3) consolidate government real property data collection into one inventory system. Real Property To: Heads of Federal Agencies Subject: Federal Real Property Profile Summary Report 1. What is the purpose of this Bulletin? This Bulletin announces the FY 2005 release of the new version of the Federal Real Property Profile (FRPP) Summary Report, which provides an overview of the U.S. Government’s owned and leased real property as of September 30, 2005. 2. What is the background? a. On February 4, 2004, the President issued Executive Order (EO) 13327, ‘‘Federal Real Property Asset Management,’’ and established the Federal Real Property Council (FRPC) to oversee the Government’s asset management planning process and to improve governmentwide real property performance. The EO requires the Administrator of General Services, in consultation with the FRPC, to develop and maintain a centralized inventory database, incorporating all key elements identified by the FRPC. b. GSA and the FRPC determined that enhancing the existing FRPP with numerous modifications and upgrades was the most cost-effective, efficient solution to meeting the FRPC requirements. The goals of the centralized database are to (1) improve decision-making with more accurate and reliable data; (2) provide the ability to benchmark Federal real property asset performance; and (3) consolidate government real property data collection into one inventory system. c. This is the first issuance of what will be an annual FRPP Summary Report generated by the newlyenhanced FRPP inventory system. The detailed information for this Summary Report is held in a password-protected PO 00000 Frm 00031 Fmt 4703 Sfmt 4703 Web-based database. This database allows Federal asset managers to update real property data on-line and in real time, produce ad hoc reports, measure performance of real property assets, and identify unneeded and underutilized assets for disposal. The FRPP Summary Report provides information regarding Federal real property holdings to stakeholders, including the Office of Management and Budget, Congress, the Federal community, and the public. Agencies confirmed their FY 2005 data summary figures prior to the FRPP Summary Report’s publication. 3. How can we obtain a copy of the FRPP summary report? You will find the FY 2005 version of the FRPP Summary Report on the GSA website at https://www.gsa.gov/realpropertyprofile. At this site, you will be able to read, print, or download this report. You can also obtain a copy from the Asset Management Division (MPA), Office of Governmentwide Policy, General Services Administration, 1800 F Street, N.W., Washington, DC 20405. 4. Who should we contact for further information regarding the FRPP? For further information, contact Stanley C. Langfeld, Director, Regulations Management Division (MPR), Office of Governmentwide Policy, General Services Administration, by phone (202) 501–1737, or by e-mail at stanley.langfeld@gsa.gov. [FR Doc. E6–8920 Filed 6–7–06; 8:45 am] BILLING CODE 6820–RH–S DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Scientific Misconduct Office of the Secretary, HHS. Notice. AGENCY: ACTION: SUMMARY: Notice is hereby given that the Office of Research Integrity (ORJ) and the Assistant Secretary for Health have taken final action in the following case: Steven Anthony Leadon, Ph.D., University of North Carolina: Based on the report of an investigation conducted by the University of North Carolina (UNC) at Chapel Hill and additional analysis conducted by ORI in its oversight review, the U.S. Public Health Service (PHS) found that Steven Anthony Leadon, Ph.D., former Professor of Radiation Oncology, Department of Radiology, School of Medicine, UNC, engaged in scientific misconduct while supported by National Cancer Institute (NCI), E:\FR\FM\08JNN1.SGM 08JNN1 cprice-sewell on PROD1PC66 with NOTICES Federal Register / Vol. 71, No. 110 / Thursday, June 8, 2006 / Notices National Institutes of Health (NIH), grant R01 CA40453–09 to 15. Specifically, PHS found that Dr. Landon engaged in scientific misconduct by falsifying DNA samples and constructing falsified figures for experiments done in his laboratory to support claimed findings of defects in a DNA repair process that involved rapid repair of DNA damage in the transcribed strand of active genes, included in four grant applications and in eight publications and one published manuscript, which were included as an Appendix to the Voluntary Exclusion Agreement entered into by Dr. Leadon and are as follows: Figures 1, 2, and 3 in the article by Gowen, L.C., Avrutskaya, A.V., Latour, A.M., Koller, B.H., & Leadon, S.A. ‘‘BRCAI Required for TranscriptionCoupled Repair of Oxidation DNA Damage.’’ Science 281:109–1012, 1988. In grant application 2 R01 CA40453–14 (p. 9), this article was used as justification for proposed research on BRCA1 and related proteins that may be required for transcription-coupled DNA repair of oxidative DNA damage. Data from the research reported in this paper was also used as preliminary data (Figure 2, p. 16) to support proposed experiments on BRCA1. • Figures 1A, 2A, and 3 in the article by Leadon, S.A. & Avrutskaya, A. ‘‘Differential Involvement of the Human Mismatch Repair Proteins, hMLH1 and hMSH2 in Transcription-coupled Repair.’’ Cancer Research 57:3784– 3791, 1997. • Figures 1 and 3 in the article by Leadon, S.A. & Avrutskaya, A.V. ‘‘Requirement for DNA Mismatch Repair Proteins in the Transcription Coupled Repair of Thymine Glycols in Saccharomyces cerevisiae.’’ Mutation Research 407:177–187, 1998. • Figures 7B and 7C in the article by Cressman, V.L., Backlund, D.C., Avrutskaya, A.V., Leadon, S.A., & Koller, B.H. ‘‘Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice.’’ Molecular and Cellular Biology 19:7061–7075, 1999. • Figures 1 A–D, 3A, 3C, ajd 3D and graphs in the unpublished manuscript by Rauscher, F. J. III, Jensen, D.E., Patel, G., Fredericks, W.J., Schultz, D.C., Proctor, M., Sekido, Y., Minna, J., Chernova, T.A., Wilkinson, K.D., Avrutskaya, A.V., & Leadon, S.A. ‘‘BRCA1-associated ubiquitin hydrolase required for transcription-coupled repair of oxidative DNA damage.’’ Submitted to Science on May 16, 2001. In figure 4 in grant application 2 R01 CA40453–14 (pp. 17–18), data from this VerDate Aug<31>2005 15:37 Jun 07, 2006 Jkt 208001 unpublished manuscript was used regarding BAP1 defects in TCR. • Figure 1A and 3A in the article by Cooper, P.K., Nouspikel, T., Clarkson, S.g., and Leadon, S.A., ‘‘Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G,’’ Science 275: 9907ndash993, 1997. In NIH grant application R01 CA40453– 10A1, some of the same data for XPG or XP–G/CS cells from this Science article were included by Dr. Leadon as graphs (Figures 4 and 5, pp. 25–27) before the Science paper was published. • Figure 1C, 2A and 2B in the article by LePage, F., Kwoh, E.E., Avrutskaya, A., Gentil, A., Leadon, S.A., Sarasin, A., & Cooper, P.K. ‘‘Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne Syndrome.’’ Cell 101:159– 171, 2000. Figure 7 in grant application 1 R01 CA092390–01. • Figures 1 and 2 and Table 1 in the article by Leadon, S.A., Barbee, S.L., & Dunn, A.B. ‘‘The yeast RAD2, but not RAD1, gene is involved in the transcription-coupled repair of thymine glycols.’’ Mutation Research 337:169– 178, 1995. • Figure 6 in the article Nouspikel, T., Lalle, P., Leadon, S.A., Cooper, P.K., & Clarkson, S.g. ‘‘A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: Implications for a second XPG function,’’ Proc. Nat. Acad. Sci. USA 94, 3116–3121, 1997. Dr. Leadon’s position is that he did not engage in scientific misconduct. His position is that a systematic error was introduced into the experiments in question and he recognizes that it could have influenced or accounted for the results. Dr. Leadon states that he has entered into a Voluntary Exclusion Agreement (Agreement) because he cannot sustain the significant financial burden of a legal proceeding to resolve the disagreements between his position and that of HHS. By entering into this Agreement, Dr. Leadon has voluntarily agreed: (1) To exclude himself from knowingly contracting or subcontracting with any agency of the United States Government and from eligibility or knowing involvement in nonprocurement programs of the United States Government referred to as ‘‘covered transactions’’ as defined in the debarment regulations at 45 CFR Part 76 for a period of five (5) years, beginning on May 10, 2006; (2) To exclude himself from serving in any advisory capacity to PHS including, but not limited, to service on any PHS advisory committee, board, and/or peer PO 00000 Frm 00032 Fmt 4703 Sfmt 4703 33309 review committee, or as consultant for a period of five (5) years, beginning on May 10, 2006; and (3) To submit letters of retraction to the editors of the journals listed below within ten (10) business days from the effective date of this Agreement, stating as follows: (A) ‘‘I have recently had the opportunity to review some of the raw data used for this paper in the above-referenced publication, and it is clear that the data as reported in this paper cannot be relied upon. Therefore, I request that you retract this paper.’’ A letter using only the aforementioned language in this subsection will be sent to Mutation Research to retract the following paper: Leadon, S.A., Barbee, S.L., & Dunn, A.B. ‘‘The yeast RAD2, but not RAD1, gene is involved in the transcription-coupled repair of thymine glycols.’’ Mutation Research 337:169–178, 1995. (B) ‘‘I have recently had the opportunity to review some of the raw data used for Figure 6 in this paper in the above-referenced publication, and it is clear that the data as reported in this figure cannot be relied upon. Therefore, I request that you retract Figure 6 of this paper.’’ A letter using only the aforementioned language in this subsection will be sent to Proceedings of National Academy of Sciences concerning the following article: Nouspikel, T., Lalle, P., Leadon, S.A., Cooper, P.K., & Clarkson, S.G. ‘‘A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: Implications for a second XPG function.’’ Proceedings of the National Academy of Sciences 94:3116–3121, 1997. (C) ‘‘I have recently had the opportunity to review some of the raw data used for Figures 7B and 7C in this paper in the abovereferenced publication, and it is clear that the data as reported in these figures cannot be relied upon. Therefore, I request that you retract Figure 7B and 7C of this paper.’’ A letter using only the aforementioned language in this subsection will be sent to Molecular and Cellular Biology concerning the following article: Cressman, V.L., Backlund, D.C., Avrutskaya, A.V., Leadon, S.A., & Koller, B.H. ‘‘Growth retardation, DNA repair defects, and lack of spermatogensis in BRCA1-deficient mice.’’ Molecular and Cellular Biology 19:7061– 7075, 1999. FOR FURTHER INFORMATION CONTACT: Director, Division of Investigative Oversight, Office of Research Integrity, 1101 Wootton Parkway, Suite 750, Rockville, MD 20852, (240) 453–8800. Chris B. Pascal, Director, Office of Research Integrity. [FR Doc. 06–5204 Filed 6–7–06; 8:45 am] BILLING CODE 4150–31–M E:\FR\FM\08JNN1.SGM 08JNN1

Agencies

[Federal Register Volume 71, Number 110 (Thursday, June 8, 2006)]
[Notices]
[Pages 33308-33309]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 06-5204]


=======================================================================
-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Office of the Secretary


Findings of Scientific Misconduct

AGENCY: Office of the Secretary, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: Notice is hereby given that the Office of Research Integrity 
(ORJ) and the Assistant Secretary for Health have taken final action in 
the following case:
    Steven Anthony Leadon, Ph.D., University of North Carolina: Based 
on the report of an investigation conducted by the University of North 
Carolina (UNC) at Chapel Hill and additional analysis conducted by ORI 
in its oversight review, the U.S. Public Health Service (PHS) found 
that Steven Anthony Leadon, Ph.D., former Professor of Radiation 
Oncology, Department of Radiology, School of Medicine, UNC, engaged in 
scientific misconduct while supported by National Cancer Institute 
(NCI),

[[Page 33309]]

National Institutes of Health (NIH), grant R01 CA40453-09 to 15.
    Specifically, PHS found that Dr. Landon engaged in scientific 
misconduct by falsifying DNA samples and constructing falsified figures 
for experiments done in his laboratory to support claimed findings of 
defects in a DNA repair process that involved rapid repair of DNA 
damage in the transcribed strand of active genes, included in four 
grant applications and in eight publications and one published 
manuscript, which were included as an Appendix to the Voluntary 
Exclusion Agreement entered into by Dr. Leadon and are as follows:
    Figures 1, 2, and 3 in the article by Gowen, L.C., Avrutskaya, 
A.V., Latour, A.M., Koller, B.H., & Leadon, S.A. ``BRCAI Required for 
Transcription-Coupled Repair of Oxidation DNA Damage.'' Science 
281:109-1012, 1988. In grant application 2 R01 CA40453-14 (p. 9), this 
article was used as justification for proposed research on BRCA1 and 
related proteins that may be required for transcription-coupled DNA 
repair of oxidative DNA damage. Data from the research reported in this 
paper was also used as preliminary data (Figure 2, p. 16) to support 
proposed experiments on BRCA1.
     Figures 1A, 2A, and 3 in the article by Leadon, S.A. & 
Avrutskaya, A. ``Differential Involvement of the Human Mismatch Repair 
Proteins, hMLH1 and hMSH2 in Transcription-coupled Repair.'' Cancer 
Research 57:3784-3791, 1997.
     Figures 1 and 3 in the article by Leadon, S.A. & 
Avrutskaya, A.V. ``Requirement for DNA Mismatch Repair Proteins in the 
Transcription Coupled Repair of Thymine Glycols in Saccharomyces 
cerevisiae.'' Mutation Research 407:177-187, 1998.
     Figures 7B and 7C in the article by Cressman, V.L., 
Backlund, D.C., Avrutskaya, A.V., Leadon, S.A., & Koller, B.H. ``Growth 
retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-
deficient mice.'' Molecular and Cellular Biology 19:7061-7075, 1999.
     Figures 1 A-D, 3A, 3C, ajd 3D and graphs in the 
unpublished manuscript by Rauscher, F. J. III, Jensen, D.E., Patel, G., 
Fredericks, W.J., Schultz, D.C., Proctor, M., Sekido, Y., Minna, J., 
Chernova, T.A., Wilkinson, K.D., Avrutskaya, A.V., & Leadon, S.A. 
``BRCA1-associated ubiquitin hydrolase required for transcription-
coupled repair of oxidative DNA damage.'' Submitted to Science on May 
16, 2001. In figure 4 in grant application 2 R01 CA40453-14 (pp. 17-
18), data from this unpublished manuscript was used regarding BAP1 
defects in TCR.
     Figure 1A and 3A in the article by Cooper, P.K., 
Nouspikel, T., Clarkson, S.g., and Leadon, S.A., ``Defective 
transcription-coupled repair of oxidative base damage in Cockayne 
syndrome patients from XP group G,'' Science 275: 9907ndash993, 1997. 
In NIH grant application R01 CA40453-10A1, some of the same data for 
XPG or XP-G/CS cells from this Science article were included by Dr. 
Leadon as graphs (Figures 4 and 5, pp. 25-27) before the Science paper 
was published.
     Figure 1C, 2A and 2B in the article by LePage, F., Kwoh, 
E.E., Avrutskaya, A., Gentil, A., Leadon, S.A., Sarasin, A., & Cooper, 
P.K. ``Transcription-coupled repair of 8-oxoguanine: requirement for 
XPG, TFIIH, and CSB and implications for Cockayne Syndrome.'' Cell 
101:159-171, 2000. Figure 7 in grant application 1 R01 CA092390-01.
     Figures 1 and 2 and Table 1 in the article by Leadon, 
S.A., Barbee, S.L., & Dunn, A.B. ``The yeast RAD2, but not RAD1, gene 
is involved in the transcription-coupled repair of thymine glycols.'' 
Mutation Research 337:169-178, 1995.
     Figure 6 in the article Nouspikel, T., Lalle, P., Leadon, 
S.A., Cooper, P.K., & Clarkson, S.g. ``A common mutational pattern in 
Cockayne syndrome patients from xeroderma pigmentosum group G: 
Implications for a second XPG function,'' Proc. Nat. Acad. Sci. USA 94, 
3116-3121, 1997.
    Dr. Leadon's position is that he did not engage in scientific 
misconduct. His position is that a systematic error was introduced into 
the experiments in question and he recognizes that it could have 
influenced or accounted for the results. Dr. Leadon states that he has 
entered into a Voluntary Exclusion Agreement (Agreement) because he 
cannot sustain the significant financial burden of a legal proceeding 
to resolve the disagreements between his position and that of HHS. By 
entering into this Agreement, Dr. Leadon has voluntarily agreed:
    (1) To exclude himself from knowingly contracting or subcontracting 
with any agency of the United States Government and from eligibility or 
knowing involvement in nonprocurement programs of the United States 
Government referred to as ``covered transactions'' as defined in the 
debarment regulations at 45 CFR Part 76 for a period of five (5) years, 
beginning on May 10, 2006;
    (2) To exclude himself from serving in any advisory capacity to PHS 
including, but not limited, to service on any PHS advisory committee, 
board, and/or peer review committee, or as consultant for a period of 
five (5) years, beginning on May 10, 2006; and
    (3) To submit letters of retraction to the editors of the journals 
listed below within ten (10) business days from the effective date of 
this Agreement, stating as follows:

    (A) ``I have recently had the opportunity to review some of the 
raw data used for this paper in the above-referenced publication, 
and it is clear that the data as reported in this paper cannot be 
relied upon. Therefore, I request that you retract this paper.'' A 
letter using only the aforementioned language in this subsection 
will be sent to Mutation Research to retract the following paper: 
Leadon, S.A., Barbee, S.L., & Dunn, A.B. ``The yeast RAD2, but not 
RAD1, gene is involved in the transcription-coupled repair of 
thymine glycols.'' Mutation Research 337:169-178, 1995.
    (B) ``I have recently had the opportunity to review some of the 
raw data used for Figure 6 in this paper in the above-referenced 
publication, and it is clear that the data as reported in this 
figure cannot be relied upon. Therefore, I request that you retract 
Figure 6 of this paper.'' A letter using only the aforementioned 
language in this subsection will be sent to Proceedings of National 
Academy of Sciences concerning the following article: Nouspikel, T., 
Lalle, P., Leadon, S.A., Cooper, P.K., & Clarkson, S.G. ``A common 
mutational pattern in Cockayne syndrome patients from xeroderma 
pigmentosum group G: Implications for a second XPG function.'' 
Proceedings of the National Academy of Sciences 94:3116-3121, 1997.
    (C) ``I have recently had the opportunity to review some of the 
raw data used for Figures 7B and 7C in this paper in the above-
referenced publication, and it is clear that the data as reported in 
these figures cannot be relied upon. Therefore, I request that you 
retract Figure 7B and 7C of this paper.'' A letter using only the 
aforementioned language in this subsection will be sent to Molecular 
and Cellular Biology concerning the following article: Cressman, 
V.L., Backlund, D.C., Avrutskaya, A.V., Leadon, S.A., & Koller, B.H. 
``Growth retardation, DNA repair defects, and lack of spermatogensis 
in BRCA1-deficient mice.'' Molecular and Cellular Biology 19:7061-
7075, 1999.

FOR FURTHER INFORMATION CONTACT: Director, Division of Investigative 
Oversight, Office of Research Integrity, 1101 Wootton Parkway, Suite 
750, Rockville, MD 20852, (240) 453-8800.


Chris B. Pascal,
Director, Office of Research Integrity.
[FR Doc. 06-5204 Filed 6-7-06; 8:45 am]
BILLING CODE 4150-31-M
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.