Government-Owned Inventions; Availability for Licensing, 26977-26978 [E6-6987]
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Federal Register / Vol. 71, No. 89 / Tuesday, May 9, 2006 / Notices
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• May 22–26, 2006—Rapid City,
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The Public Health Service (PHS)
strongly encourages all grant and
contract recipients to provide a smokefree workplace and promote the non-use
of all tobacco products. In addition,
Public Law 103–227, the Pro-Children
Act of 1994, prohibits smoking in
certain facilities (or in some cases, any
portion of the facility) in which regular
or routine education, library, day care,
health care or early childhood
development services are provided to
children. This is consistent with the
HHS mission to protect and advance the
physical and mental health of the
American people.
Dated: May 2, 2006.
Robert G. McSwain,
Deputy Director, Indian Health Service.
[FR Doc. 06–4292 Filed 5–8–06; 8:45 am]
BILLING CODE 4165–16–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions;
Availability for Licensing
National Institutes of Health,
Public Health Service, HHS.
ACTION: Notice.
mstockstill on PROD1PC68 with NOTICES
AGENCY:
SUMMARY: The inventions listed below
are owned by an agency of the U.S.
Government and are available for
licensing in the U.S. in accordance with
35 U.S.C. 207 to achieve expeditious
commercialization of results of
Federally-funded research and
development. Foreign patent
applications are filed on selected
inventions to extend market coverage
for companies and may also be available
for licensing.
VerDate Aug<31>2005
15:42 May 08, 2006
Jkt 208001
Licensing information and
copies of the U.S. patent applications
listed below may be obtained by writing
to the indicated licensing contact at the
Office of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville,
Maryland 20852–3804; telephone: (301)
496–7057; fax: (301) 402–0220. A signed
Confidential Disclosure Agreement will
be required to receive copies of the
patent applications.
ADDRESSES:
New Method for Quantification of
Allele-Specific RNA Expression, That
Can Be Used for Detection of Various
Genetic Disorders
Drs. Marjan Huizing, Enriko Klootwijk,
Paul Savelkoul, Carla Ciccone,
William Gahl (NHGRI)
U.S. Provisional Application No. 60/
718,321 filed 20 Sep 2005 (HHS
Reference No. E–146–2005/0–US–01)
Licensing Contact: Cristina
Thalhammer-Reyero; 301/435–4507;
thalhamc@mail.nih.gov.
Available for licensing and
commercial development is a new
method for quantification of allelespecific RNA expression. This invention
describes methods for simultaneously
detecting the levels of expression of a
plurality of different RNA transcripts
expressed from a gene of interest in a
subject or a cell. This is a simple assay
to validate and quantify allele-specific
silencing, by applying a combination of
a fluorescent primer/probe set that
specifically recognizes the targeted
allele where the probe is labeled with
one fluorophore, and a primer/probe set
that specifically recognizes the normal
allele, where the probe is labeled with
another fluorophore in the same
reaction tube. Furthermore, this method
can be run on most real time PCR
machines and requires very small
amounts of RNA, less than 100 ng. This
novel method, by comparing alleles
within the same gene, expands on
current real time PCR methods which
compare one gene with another gene.
The invention also describes methods
for validating the effectiveness and
specificity of allele-specific siRNAs, kits
for performing such assays, as well as
methods for diagnosis of autosomaldominant disorders, in which mutations
in one allele result in a disease
phenotype, such as Hutchinson-Gilford
progeria, incontinentia pigmenti,
neurofibromatosis, myotonic dystrophy,
sialuria, Machado-Joseph disease,
spinocerebellar ataxia, frontotemporal
dementia, amyotrophic lateral sclerosis,
slow channel congenital myasthenic
syndrome, spinobulbar muscular
dystrophy, as well as compound
heterozygous autosomal recessive
PO 00000
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Fmt 4703
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26977
disorders. Other diseases that can be
diagnosed include diabetes, cystic
fibrosis, homocystenuria, HermanskyPudlak syndrome, cystinosis, Zellweger
syndrome, beta-thalassemia,
alkaptonuria, and cancer.
A variety of diseases appear to be
mediated or accompanied by aberrant
expression of one allele, often a mutant
of a gene. Such differences in allelic
expression can serve as the basis for
diagnostic test for such conditions, and
the ability to specifically silence the
expression of detrimental alleles could
be a therapeutic method for treating the
disease, hence this novel method has
very wide applications.
Development of Gene Chip Technology
for Vascular Risk Assessment
Alison E. Baird (NINDS) et al.
U.S. Provisional Application No. 60/
687,515 filed 03 Jun 2005 (HHS
Reference No. E–030–2005/0–US–01)
U.S. Provisional Application No. 60/
691,730 filed 17 Jun 2005 (HHS
Reference No. E–030–2005/1–US–01)
Licensing Contact: Fatima Sayyid; 301/
435–4521; sayyidf@mail.nih.gov.
Prevention of cardiovascular
disorders such as myocardial infarction
and stroke is an area of major public
health importance. Currently, several
risk factors for future cardiovascular
disorders have been described and are
in wide clinical use in the detection of
individuals at high risk. However a large
number of cardiovascular disorders
occur in individuals with apparently
low to moderate risk profiles, thereby
limiting the ability to identify such
patients. Moreover, many of the risk
factors require accurate gathering of
clinical information. An objective panel
of biological markers which allow one
to predict an individual’s risk of
vascular disease is therefore needed.
The present provisional patent
application is directed to utilizing blood
mononuclear cells to evaluate vascular
disease risk and determine a preventive
regimen for reduction or minimization
of such risk. The method includes
screening for differential expression of
vascular risk-related molecules, such as
DNA binding/transcription factor
proteins, lysosomal or protein
degradation enzymes, adhesion
molecules, metabolism molecules,
intracellular signaling molecules,
immune response molecules and
apoptosis. The technology is available to
a collaborator for monitoring stroke
treatment protocols, for definition of
clinical trial protocol candidates, or for
developing an ‘‘assessment chip’’ that
could be used to predict an individual’s
risk of developing a stroke in the future.
E:\FR\FM\09MYN1.SGM
09MYN1
26978
Federal Register / Vol. 71, No. 89 / Tuesday, May 9, 2006 / Notices
The NINDS Stroke Neuroscience Unit
is seeking statements of capability or
interest from parties interested in
collaborative research to further
develop, evaluate, or commercialize a
vascular risk genetic chip technology.
We seek a collaborative partner in the
development of a chip that could be
used to predict an individual’s risk of
developing a stroke in the future and to
monitor the effectiveness of preventive
measures once they have been
instituted. Please contact Heather Gunas
at gunash@mail.nih.gov for more
information.
Method of Inducing Memory B Cell
Development and Terminal
Differentiation
Peter E. Lipsky (NIAMS) et al.
U.S. Patent Application No. 11/197,221
filed 03 Aug 2005 (HHS Reference No.
E–120–2003/2–US–01)
Licensing Contact: Thomas Clouse; 301/
435–4076; clousetp@mail.nih.gov.
Cytokines exert their respective
biochemical and physiological effects by
binding to specific receptor molecules,
which then stimulate signal
transduction pathways. Interleukin-21
(1L-21) is a type I cytokine whose
receptor is expressed on T, B, and NK
cells.
This invention specifically relates to
the use of IL-21 to induce differentiation
of immature B cells into memory B cells
and plasma cells. This invention
includes claims of methods for inducing
differentiation of a B cell progenitor into
memory B cells and/or plasma cells. It
also includes claims for enhancing an
immune response, treating subjects that
lack memory B cells and plasma cells
and methods for increasing or
decreasing the number of B cells. This
invention could conceivably be used in
treating or preventing inflammatory
disorders, autoimmune diseases,
allergies, transplant rejection, cancer,
and other immune system disorders.
mstockstill on PROD1PC68 with NOTICES
Immunogenic Epitopes for Fibroblast
Growth Factor-5 (FGF–5) Presented by
HLA-A3 and HLA-A2
James C. Yang et al. (NCI)
U.S. Patent Application No. 11/134,703
filed 19 May 2005 (HHS Reference
No. E–031–2003/1–US–01)
Licensing Contact: Michelle Booden;
301/451–7337;
boodenm@mail.nih.gov.
Approximately 30,000 patients are
diagnosed with renal cell carcinoma
(RCC) each year in the United States,
and an estimated 12,000 patients die of
this disease. Most patients are
diagnosed with advanced local disease
or metastatic disease. Current therapies
VerDate Aug<31>2005
15:42 May 08, 2006
Jkt 208001
include removal of the kidney
(nephrectomy) or high dose
immunotherapy with IL-2, which has
been able to achieve success in only part
(15–20%) of the patient population.
Even with a successful nephrectomy, it
is likely that patients with advanced
local diseases will develop metastases.
Therefore, new methods are needed to
improve on IL-2 therapy and expand the
curative potential of therapies for
patients with RCC.
The present invention discloses
peptides for use in immunotherapy of
tumors. The peptides, both an HLA-A2
and an HLA-A3 epitope, are derived
from the amino acid sequence of an
RCC-associated antigen, fibroblast
growth factor-5 (FGF–5). Plans are
underway to investigate both peptides
in clinical trials of peptide vaccination
in patients with advanced renal cancer.
In addition, FGF–5 also appears to be
over-expressed in other common
adenocarcinomas such as breast,
prostate and bladder cancer and very
few antigens suitable for vaccine
therapies exist for those cancers.
In addition to licensing, the
technology is available for further
development through collaborative
research opportunities with the
inventors.
Dated: May 2, 2005.
David R. Sadowski,
Acting Director, Division of Technology
Development and Transfer, Office of
Technology Transfer, National Institutes of
Health.
[FR Doc. E6–6987 Filed 5–8–06; 8:45 am]
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Child Health and Human Development
Special Emphasis Panel, Data Coordinating
Center for Consortium on Safe Labor.
Date: May 22, 2006.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate contact
proposals.
Place: Ramada Inn Rockville, 1775
Rockville Pike, Rockville, MD 20852.
Contact Person: Hameed Khan, PhD,
Scientific Review Administrator, Division of
Scientific Review, National Institute of Child
Health and Human Development, NIH, 6100
Executive Blvd., Room 5B01, Bethesda, MD
20892, (301) 435–6902, khanh@mail.nih.gov.
Name of Committee: National Institute of
Child Health and Human Development
Special Emphasis Panel, Consumers’ Report
on Prosthetics and Assistive Technology.
Date: May 25, 2006.
Time: 12 p.m. to 2 p.m.
Agenda: To review and evaluate contract
proposals.
Place: National Institutes of Health, 6100
Executive Boulevard, Room 5B01, Rockville,
MD 20852, (Telephone Conference Call).
Contact Person: Hameed Khan, PhD,
Scientific Review Administrator, Division of
Scientific Review, National Institute of Child
Health and Human Development, NIH, 6100
Executive Blvd., Room 5B01, Bethesda, MD
20892, (301) 435–6902, khanh@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.864, Population Research;
93.865, Research for Mothers and Children;
93.929, Center for Medical Rehabilitation
Research; 93.209, Contraception and
Infertility Loan Repayment Program, National
Institutes of Health, HHS)
BILLING CODE 4167–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Dated: April 30, 2006.
Anna Snouffer,
Acting Director, Office of the Federal Advisory
Committee Policy.
[FR Doc. 06–4297 Filed 5–8–06; 8:45am]
BILLING CODE 4140–01–M
National Institutes of Health
National Institute of Child Health and
Human Development; Notice of Closed
Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The contract proposals and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the contract
proposals, the disclosure of which
PO 00000
Frm 00059
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Sfmt 4703
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Diabetes and
Digestive and Kidney Diseases; Notice
of Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given for the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
E:\FR\FM\09MYN1.SGM
09MYN1
]]>Agencies
[Federal Register Volume 71, Number 89 (Tuesday, May 9, 2006)]
[Notices]
[Pages 26977-26978]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E6-6987]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of Federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804; telephone: (301) 496-7057; fax: (301) 402-0220. A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
New Method for Quantification of Allele-Specific RNA Expression, That
Can Be Used for Detection of Various Genetic Disorders
Drs. Marjan Huizing, Enriko Klootwijk, Paul Savelkoul, Carla Ciccone,
William Gahl (NHGRI)
U.S. Provisional Application No. 60/718,321 filed 20 Sep 2005 (HHS
Reference No. E-146-2005/0-US-01)
Licensing Contact: Cristina Thalhammer-Reyero; 301/435-4507;
thalhamc@mail.nih.gov.
Available for licensing and commercial development is a new method
for quantification of allele-specific RNA expression. This invention
describes methods for simultaneously detecting the levels of expression
of a plurality of different RNA transcripts expressed from a gene of
interest in a subject or a cell. This is a simple assay to validate and
quantify allele-specific silencing, by applying a combination of a
fluorescent primer/probe set that specifically recognizes the targeted
allele where the probe is labeled with one fluorophore, and a primer/
probe set that specifically recognizes the normal allele, where the
probe is labeled with another fluorophore in the same reaction tube.
Furthermore, this method can be run on most real time PCR machines and
requires very small amounts of RNA, less than 100 ng. This novel
method, by comparing alleles within the same gene, expands on current
real time PCR methods which compare one gene with another gene.
The invention also describes methods for validating the
effectiveness and specificity of allele-specific siRNAs, kits for
performing such assays, as well as methods for diagnosis of autosomal-
dominant disorders, in which mutations in one allele result in a
disease phenotype, such as Hutchinson-Gilford progeria, incontinentia
pigmenti, neurofibromatosis, myotonic dystrophy, sialuria, Machado-
Joseph disease, spinocerebellar ataxia, frontotemporal dementia,
amyotrophic lateral sclerosis, slow channel congenital myasthenic
syndrome, spinobulbar muscular dystrophy, as well as compound
heterozygous autosomal recessive disorders. Other diseases that can be
diagnosed include diabetes, cystic fibrosis, homocystenuria, Hermansky-
Pudlak syndrome, cystinosis, Zellweger syndrome, beta-thalassemia,
alkaptonuria, and cancer.
A variety of diseases appear to be mediated or accompanied by
aberrant expression of one allele, often a mutant of a gene. Such
differences in allelic expression can serve as the basis for diagnostic
test for such conditions, and the ability to specifically silence the
expression of detrimental alleles could be a therapeutic method for
treating the disease, hence this novel method has very wide
applications.
Development of Gene Chip Technology for Vascular Risk Assessment
Alison E. Baird (NINDS) et al.
U.S. Provisional Application No. 60/687,515 filed 03 Jun 2005 (HHS
Reference No. E-030-2005/0-US-01)
U.S. Provisional Application No. 60/691,730 filed 17 Jun 2005 (HHS
Reference No. E-030-2005/1-US-01)
Licensing Contact: Fatima Sayyid; 301/435-4521; sayyidf@mail.nih.gov.
Prevention of cardiovascular disorders such as myocardial
infarction and stroke is an area of major public health importance.
Currently, several risk factors for future cardiovascular disorders
have been described and are in wide clinical use in the detection of
individuals at high risk. However a large number of cardiovascular
disorders occur in individuals with apparently low to moderate risk
profiles, thereby limiting the ability to identify such patients.
Moreover, many of the risk factors require accurate gathering of
clinical information. An objective panel of biological markers which
allow one to predict an individual's risk of vascular disease is
therefore needed.
The present provisional patent application is directed to utilizing
blood mononuclear cells to evaluate vascular disease risk and determine
a preventive regimen for reduction or minimization of such risk. The
method includes screening for differential expression of vascular risk-
related molecules, such as DNA binding/transcription factor proteins,
lysosomal or protein degradation enzymes, adhesion molecules,
metabolism molecules, intracellular signaling molecules, immune
response molecules and apoptosis. The technology is available to a
collaborator for monitoring stroke treatment protocols, for definition
of clinical trial protocol candidates, or for developing an
``assessment chip'' that could be used to predict an individual's risk
of developing a stroke in the future.
[[Page 26978]]
The NINDS Stroke Neuroscience Unit is seeking statements of
capability or interest from parties interested in collaborative
research to further develop, evaluate, or commercialize a vascular risk
genetic chip technology. We seek a collaborative partner in the
development of a chip that could be used to predict an individual's
risk of developing a stroke in the future and to monitor the
effectiveness of preventive measures once they have been instituted.
Please contact Heather Gunas at gunash@mail.nih.gov for more
information.
Method of Inducing Memory B Cell Development and Terminal
Differentiation
Peter E. Lipsky (NIAMS) et al.
U.S. Patent Application No. 11/197,221 filed 03 Aug 2005 (HHS Reference
No. E-120-2003/2-US-01)
Licensing Contact: Thomas Clouse; 301/435-4076; clousetp@mail.nih.gov.
Cytokines exert their respective biochemical and physiological
effects by binding to specific receptor molecules, which then stimulate
signal transduction pathways. Interleukin-21 (1L-21) is a type I
cytokine whose receptor is expressed on T, B, and NK cells.
This invention specifically relates to the use of IL-21 to induce
differentiation of immature B cells into memory B cells and plasma
cells. This invention includes claims of methods for inducing
differentiation of a B cell progenitor into memory B cells and/or
plasma cells. It also includes claims for enhancing an immune response,
treating subjects that lack memory B cells and plasma cells and methods
for increasing or decreasing the number of B cells. This invention
could conceivably be used in treating or preventing inflammatory
disorders, autoimmune diseases, allergies, transplant rejection,
cancer, and other immune system disorders.
Immunogenic Epitopes for Fibroblast Growth Factor-5 (FGF-5) Presented
by HLA-A3 and HLA-A2
James C. Yang et al. (NCI)
U.S. Patent Application No. 11/134,703 filed 19 May 2005 (HHS Reference
No. E-031-2003/1-US-01)
Licensing Contact: Michelle Booden; 301/451-7337; boodenm@mail.nih.gov.
Approximately 30,000 patients are diagnosed with renal cell
carcinoma (RCC) each year in the United States, and an estimated 12,000
patients die of this disease. Most patients are diagnosed with advanced
local disease or metastatic disease. Current therapies include removal
of the kidney (nephrectomy) or high dose immunotherapy with IL-2, which
has been able to achieve success in only part (15-20%) of the patient
population. Even with a successful nephrectomy, it is likely that
patients with advanced local diseases will develop metastases.
Therefore, new methods are needed to improve on IL-2 therapy and expand
the curative potential of therapies for patients with RCC.
The present invention discloses peptides for use in immunotherapy
of tumors. The peptides, both an HLA-A2 and an HLA-A3 epitope, are
derived from the amino acid sequence of an RCC-associated antigen,
fibroblast growth factor-5 (FGF-5). Plans are underway to investigate
both peptides in clinical trials of peptide vaccination in patients
with advanced renal cancer. In addition, FGF-5 also appears to be over-
expressed in other common adenocarcinomas such as breast, prostate and
bladder cancer and very few antigens suitable for vaccine therapies
exist for those cancers.
In addition to licensing, the technology is available for further
development through collaborative research opportunities with the
inventors.
Dated: May 2, 2005.
David R. Sadowski,
Acting Director, Division of Technology Development and Transfer,
Office of Technology Transfer, National Institutes of Health.
[FR Doc. E6-6987 Filed 5-8-06; 8:45 am]
BILLING CODE 4167-01-P
