Prospective Grant of Exclusive License: The Development of C-6 and C-8 Modified cAMP-Derivatives for the Treatment of Cancer, 26979 [E6-6986]

Download as PDF Federal Register / Vol. 71, No. 89 / Tuesday, May 9, 2006 / Notices and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, Biomarkers of Autoimmunity in Type 1 Diabetes. Date: June 14, 2006. Time: 8:30 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Double Tree Rockville, 1750 Rockville Pike, Rockville, MD 20852. Contact Person: Xiaodu Guo, MD, Ph.D., Scientific Review Administrator, Review Branch, DEA, NIDDK, National Institutes of Health, Room 927, 6707 Democracy Boulevard, Bethesda, MD 20892–5452, (301) 594–4719, guox@extra.niddk.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.947, Diabetes, Endocrinology and Metabolic Research; 93.848, Digestive Diseases and Nutrition Research; 93.849, Kidney Disease, Urology and Hematology Research, National Institutes of Health, HHS) Dated: April 30, 2006. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 06–4298 Filed 5–8–06; 8:45am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of Exclusive License: The Development of C-6 and C-8 Modified cAMP-Derivatives for the Treatment of Cancer National Institutes of Health, Public Health Service, HHS. ACTION: Notice. mstockstill on PROD1PC68 with NOTICES AGENCY: SUMMARY: This notice, in accordance with 35 U.S.C. 209(c)(1) and 37 CFR Part 404.7(a)(1)(i), that the National Institutes of Health (NIH), Department of Health and Human Services (HHS), is contemplating the grant of an exclusive patent license to practice the inventions embodied in U.S. Patent Application No. 07/198,489 filed May 23, 1988, entitled ‘‘Use of 8-Cl-cAMP as Anticancer Drug’’ [HHS Reference No. E–132–1988/0–US–01], PCT Application filed May 19, 1989 [HHS Reference No. E–132–1988/0–PCT–02], U.S. Patent Application No. 07/896,452 filed June 4, 1992, entitled ‘‘Use of 8-ClcAMP as Anticancer Drug’’ [HHS Reference No. E–132–1988/0–US–04], U.S. Patent 5,792,752 filed October 27, 1994 and issued August 11, 1998, entitled ‘‘Use of 8-Cl-cAMP as VerDate Aug<31>2005 15:42 May 08, 2006 Jkt 208001 Anticancer Drug’’ [HHS Reference No. E–132–1988/0–US–05], U.S. Patent 5,902,794 filed September 22, 1997 and issued May 11, 1999, entitled ‘‘Use of 8Cl-cAMP as Anticancer Drug’’ [HHS Reference No. E–132–1988/0–US–06] and Canadian Patent Application No. 133572 filed May 19, 1989, entitled ‘‘Use of 8-Cl-cAMP as Anticancer Drug’’ [HHS Reference No. E–132–1988/0–CA– 03], to Kuhnil Pharm. Co. Ltd., which has offices in Seoul, Republic of Korea. The patent rights in these inventions have been assigned and/or exclusively licensed to the Government of the United States of America. The prospective exclusive license territory may be worldwide, and the field of use may be limited to the treatment of cancer with 8-Cl-cAMP. DATES: Only written comments and/or applications for a license which are received by the NIH Office of Technology Transfer on or before June 10, 2006 will be considered. ADDRESSES: Requests for copies of the patent application, inquiries, comments, and other materials relating to the contemplated exclusive license should be directed to: David A. Lambertson, Ph.D., Technology Licensing Specialist, Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852–3804; Telephone: (301) 435– 4632; Facsimile: (301) 402–0220; E-mail: lambertsond@od.nih.gov. SUPPLEMENTARY INFORMATION: Cyclic AMP (cAMP) is a natural biological product with a number of regulatory functions at physiological levels. At higher than physiological concentrations, cAMP has the ability to inhibit the aberrant growth of malignant cells. Because cAMP is a natural product involved in normal biological function, this inhibition occurs without causing significant toxicity. However, this is not a feasible method for treating cancer in vivo because of potential interference with the physiological role of cAMP. C-6 and C-8 modified cAMP derivatives also inhibit the growth of malignant cells. One such derivative, 8Cl-cAMP, has effectively decreased tumor growth in vitro and in vivo. Specifically, 8-Cl-cAMP showed the ability to decrease tumor growth in leukemia mouse models and xenografts of human tumors. Because of the low toxicity associated with 8-Cl-cAMP, this compound has promise as an anticancer agent, particularly with regard to hematological malignancies. The prospective exclusive license will be royalty bearing and will comply with the terms and conditions of 35 U.S.C. PO 00000 Frm 00060 Fmt 4703 Sfmt 4703 26979 209 and 37 CFR part 404.7. The prospective exclusive license may be granted unless within sixty (60) days from the date of this published notice, the NIH receives written evidence and argument that establishes that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR 404.7. Applications for a license in the field of use filed in response to this notice will be treated as objections to the grant of the contemplated exclusive license. Comments and objections submitted to this notice will not be made available for public inspection and, to the extent permitted by law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. Dated: May 2, 2006. David R. Sadowski, Acting Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E6–6986 Filed 5–8-06; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Extension of a Currently Approved Information Collection; Comment Request. 30-Day Notice of Information Collection under Review: Application for Certificate of Citizenship, Form N– 600. OMB Control No. 1615–0057. ACTION: The Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) has submitted the following information collection request to the Office of Management and Budget (OMB) for review and clearance in accordance with the Paperwork Reduction Act of 1995. The information collection was previously published in the Federal Register on February 28, 2006, at 71 FR 10048. The notice allowed for a 60-day public comment period. No comments were received on this information collection. The purpose of this notice is to allow an additional 30 days for public comments. Comments are encouraged and will be accepted until June 8, 2006. This process is conducted in accordance with 5 CFR 1320.10. Written comments and/or suggestions regarding the item(s) contained in this notice, especially regarding the E:\FR\FM\09MYN1.SGM 09MYN1

Agencies

[Federal Register Volume 71, Number 89 (Tuesday, May 9, 2006)]
[Notices]
[Page 26979]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E6-6986]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of Exclusive License: The Development of C-6 
and C-8 Modified cAMP-Derivatives for the Treatment of Cancer

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: This notice, in accordance with 35 U.S.C. 209(c)(1) and 37 CFR 
Part 404.7(a)(1)(i), that the National Institutes of Health (NIH), 
Department of Health and Human Services (HHS), is contemplating the 
grant of an exclusive patent license to practice the inventions 
embodied in U.S. Patent Application No. 07/198,489 filed May 23, 1988, 
entitled ``Use of 8-Cl-cAMP as Anticancer Drug'' [HHS Reference No. E-
132-1988/0-US-01], PCT Application filed May 19, 1989 [HHS Reference 
No. E-132-1988/0-PCT-02], U.S. Patent Application No. 07/896,452 filed 
June 4, 1992, entitled ``Use of 8-Cl-cAMP as Anticancer Drug'' [HHS 
Reference No. E-132-1988/0-US-04], U.S. Patent 5,792,752 filed October 
27, 1994 and issued August 11, 1998, entitled ``Use of 8-Cl-cAMP as 
Anticancer Drug'' [HHS Reference No. E-132-1988/0-US-05], U.S. Patent 
5,902,794 filed September 22, 1997 and issued May 11, 1999, entitled 
``Use of 8-Cl-cAMP as Anticancer Drug'' [HHS Reference No. E-132-1988/
0-US-06] and Canadian Patent Application No. 133572 filed May 19, 1989, 
entitled ``Use of 8-Cl-cAMP as Anticancer Drug'' [HHS Reference No. E-
132-1988/0-CA-03], to Kuhnil Pharm. Co. Ltd., which has offices in 
Seoul, Republic of Korea. The patent rights in these inventions have 
been assigned and/or exclusively licensed to the Government of the 
United States of America.
    The prospective exclusive license territory may be worldwide, and 
the field of use may be limited to the treatment of cancer with 8-Cl-
cAMP.

DATES: Only written comments and/or applications for a license which 
are received by the NIH Office of Technology Transfer on or before June 
10, 2006 will be considered.

ADDRESSES: Requests for copies of the patent application, inquiries, 
comments, and other materials relating to the contemplated exclusive 
license should be directed to: David A. Lambertson, Ph.D., Technology 
Licensing Specialist, Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
MD 20852-3804; Telephone: (301) 435-4632; Facsimile: (301) 402-0220; E-
mail: lambertsond@od.nih.gov.

SUPPLEMENTARY INFORMATION: Cyclic AMP (cAMP) is a natural biological 
product with a number of regulatory functions at physiological levels. 
At higher than physiological concentrations, cAMP has the ability to 
inhibit the aberrant growth of malignant cells. Because cAMP is a 
natural product involved in normal biological function, this inhibition 
occurs without causing significant toxicity. However, this is not a 
feasible method for treating cancer in vivo because of potential 
interference with the physiological role of cAMP.
    C-6 and C-8 modified cAMP derivatives also inhibit the growth of 
malignant cells. One such derivative, 8-Cl-cAMP, has effectively 
decreased tumor growth in vitro and in vivo. Specifically, 8-Cl-cAMP 
showed the ability to decrease tumor growth in leukemia mouse models 
and xenografts of human tumors. Because of the low toxicity associated 
with 8-Cl-cAMP, this compound has promise as an anti-cancer agent, 
particularly with regard to hematological malignancies.
    The prospective exclusive license will be royalty bearing and will 
comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR part 
404.7. The prospective exclusive license may be granted unless within 
sixty (60) days from the date of this published notice, the NIH 
receives written evidence and argument that establishes that the grant 
of the license would not be consistent with the requirements of 35 
U.S.C. 209 and 37 CFR 404.7.
    Applications for a license in the field of use filed in response to 
this notice will be treated as objections to the grant of the 
contemplated exclusive license. Comments and objections submitted to 
this notice will not be made available for public inspection and, to 
the extent permitted by law, will not be released under the Freedom of 
Information Act, 5 U.S.C. 552.

    Dated: May 2, 2006.
David R. Sadowski,
Acting Director, Division of Technology Development and Transfer, 
Office of Technology Transfer, National Institutes of Health.
[FR Doc. E6-6986 Filed 5-8-06; 8:45 am]
BILLING CODE 4140-01-P

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