National Cancer Institute; Notice of Meeting, 7782 [06-1323]
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7782
Federal Register / Vol. 71, No. 30 / Tuesday, February 14, 2006 / Notices
compounds is a billion dollar industry.
The diversity of compounds that elicit
bitter-taste sensations is very large and
more than two dozen members of the
T2R bitter taste receptor family have
been identified. Individuals are now
known to be genetically predisposed to
respond or not to respond to the bitter
taste of a number of substances. For
example, large individual differences in
the perception of bitterness have been
well documented in compounds as
different as nicotine, thiocyanates such
as those found in cruciferous vegetables,
and many bitter beta-glucopyranosides.
This may have broad implications for
nutritional status and tobacco use and
common allelic variants of a member of
the T2R bitter taste receptor gene family
have been shown to underlie variation
in the ability to taste
phenylthiocarbamide (PTC) [Science
(2003) 299, 1221–1225; HHS Ref No: E–
169–2001/0].
Scientists at the NIDCD have
extended these results to other bitter
taste receptors and have sequenced 22
of the 24 known T2R genes in a series
of populations worldwide, including
Northern Europeans, Hungarians,
Japanese, Cameroonians, Pygmies and
South American Indians and the present
invention includes these isolated
sequences and their variants. This
includes a total of 127 SNPs and 103
different protein coding haplotypes,
including those defined for the PTC
Receptor (T2R38) [E–169–2001/0]. The
inventors showed that 77% of the SNPs
identified caused an amino acid
substitution in the encoded receptor
protein, giving rise to a very high degree
of receptor protein variation in the
population (Kim et al. (2005) Human
Mutation 26, 199–204). The frequencies
of these different haplotypes have been
shown to differ in different populations
which will aid in population-specific
studies, such as those targeting
differences in taste perception between
Europeans and Asians, for example.
The invention available for licensing
includes these novel SNPs and
haplotypes and methods of use, which
can be used to better identify and
characterize different groups of
individuals within and between
populations that vary in their bitter taste
abilities. This is important to the food
and flavoring industry, for example,
where these variants can be used to aid
in the development of a variety of taste
improvements in foods and orally
administered medications. [Also
available for licensing in the Human
Taste Receptor Haplotype patent
portfolio is HHS Ref No. E–169–2001/0PCT–02: Phenylthiocarbamide Taste
Receptor, International Publication No.
VerDate Aug<31>2005
14:46 Feb 13, 2006
Jkt 208001
WO 2003/008627, PCT filed July 19,
2002 and global IP, and HHS Ref. No
099–2005/0: Human Sweet and Umami
Taste Receptor Genes, U.S. Provisional
Patent Application No. 60/671,173 filed
April 2005].
In addition to licensing, the
technology is available for further
development through collaborative
research opportunities with the
inventors.
Dated: February 2, 2006.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E6–2015 Filed 2–13–06; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Cancer Institute; Notice of
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby give of a meeting of the Board
of Scientific Counselors for Basic
Sciences National Cancer Institute.
The meeting will be open to the
public as indicated below, with
attendance limited to space available.
Individuals who plan to attend and
need special assistance, such as sign
language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting. The meeting
will be closed to the public as indicated
below in accordance with the provisions
set forth in section 552b(c)(6), Title 5
U.S.C., as amended for the review,
discussion, and evaluation of individual
intramural programs and projects
conducted by the National Cancer
Institute, including consideration of
personnel qualifications and
performance, and the competence of
individual investigators, the disclosure
of which would constitute a clearly
unwarranted invasion of personal
privacy.
Name of Committee: Board of Scientific
Counselors for Basic Sciences National
Cancer Institute.
Date: March 13, 2006.
Open: 8 a.m. to 10:30 a.m.
Agenda: Joint Session of NCI, Board of
Scientific Advisors and Boards of Scientific
Counselors.
Place: National Institutes of Health,
National Cancer Institute, 9000 Rockville
Pike, Building 31, Conference Room 10,
Bethesda, MD 20892.
Closed: 11 a.m. to 7:30 p.m.
PO 00000
Frm 00062
Fmt 4703
Sfmt 4703
Agenda: To review and evaluate personal
qualifications and performance, and
competence of individual investigators.
Place: National Institutes of Health,
National Cancer Institute, 9000 Rockville
Pike, Building 31, Conference Room 6,
Bethesda, MD 20892.
Contact Person: Florence E. Farber, PhD,
Executive Secretary, Office of the Director,
National Cancer Institute, National Institutes
of Health, 6116 Executive Boulevard, Room
2115, Bethesda, MD 20892. 301–496–7628.
ff6p@nih.gov.
Any interested person may file written
comments with the committee by forwarding
the statement to the Contact Person listed on
this notice. The statement should include the
name, address, telephone number and when
applicable, the business or professional
affiliation of the interested person.
In the interest of security, NIH has
instituted stringent procedures for entrance
into the building by non-government
employees. Persons without a government
I.D. will need to show a photo I.D. and signin at the security desk upon entering the
building.
(Catalogue of Federal Domestic
Assistance Program Nos. 93.392, Cancer
Construction; 93.393, Cancer Cause and
Prevention Research; 93.394, Cancer
Detection and Diagnosis Research;
93.395, Cancer Treatment Research;
93.396, Cancer Biology Research;
93.397, Cancer Centers Support; 93.398,
Cancer Research Manpower; 93.399,
Cancer Control, National Institutes of
Health, HHS)
Dated: February 1, 2006.
Anna Snouffer,
Acting Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 06–1323 Filed 2–13–06; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Cancer Institute; Notice of
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of a meeting of the
Board of Scientific Counselors for
Clinical Sciences and Epidemiology
National Cancer Institute.
The meeting will be open to the
public as indicated below, with
attendance limited to space available.
Individuals who plan to attend and
need special assistance, such as sign
language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
The meeting will be closed to the
public as indicated below in accordance
E:\FR\FM\14FEN1.SGM
14FEN1
]]>Agencies
[Federal Register Volume 71, Number 30 (Tuesday, February 14, 2006)]
[Notices]
[Page 7782]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 06-1323]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Cancer Institute; Notice of Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice is hereby give of a meeting of
the Board of Scientific Counselors for Basic Sciences National Cancer
Institute.
The meeting will be open to the public as indicated below, with
attendance limited to space available. Individuals who plan to attend
and need special assistance, such as sign language interpretation or
other reasonable accommodations, should notify the Contact Person
listed below in advance of the meeting. The meeting will be closed to
the public as indicated below in accordance with the provisions set
forth in section 552b(c)(6), Title 5 U.S.C., as amended for the review,
discussion, and evaluation of individual intramural programs and
projects conducted by the National Cancer Institute, including
consideration of personnel qualifications and performance, and the
competence of individual investigators, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: Board of Scientific Counselors for Basic
Sciences National Cancer Institute.
Date: March 13, 2006.
Open: 8 a.m. to 10:30 a.m.
Agenda: Joint Session of NCI, Board of Scientific Advisors and
Boards of Scientific Counselors.
Place: National Institutes of Health, National Cancer Institute,
9000 Rockville Pike, Building 31, Conference Room 10, Bethesda, MD
20892.
Closed: 11 a.m. to 7:30 p.m.
Agenda: To review and evaluate personal qualifications and
performance, and competence of individual investigators.
Place: National Institutes of Health, National Cancer Institute,
9000 Rockville Pike, Building 31, Conference Room 6, Bethesda, MD
20892.
Contact Person: Florence E. Farber, PhD, Executive Secretary,
Office of the Director, National Cancer Institute, National
Institutes of Health, 6116 Executive Boulevard, Room 2115, Bethesda,
MD 20892. 301-496-7628. ff6p@nih.gov.
Any interested person may file written comments with the
committee by forwarding the statement to the Contact Person listed
on this notice. The statement should include the name, address,
telephone number and when applicable, the business or professional
affiliation of the interested person.
In the interest of security, NIH has instituted stringent
procedures for entrance into the building by non-government
employees. Persons without a government I.D. will need to show a
photo I.D. and sign-in at the security desk upon entering the
building.
(Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer
Construction; 93.393, Cancer Cause and Prevention Research; 93.394,
Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment
Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers
Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control,
National Institutes of Health, HHS)
Dated: February 1, 2006.
Anna Snouffer,
Acting Director, Office of Federal Advisory Committee Policy.
[FR Doc. 06-1323 Filed 2-13-06; 8:45 am]
BILLING CODE 4140-01-M
