Prospective Grant of Exclusive License: Aminoflavone Compounds as Anti-Cancer Agents, 6515-6516 [E6-1651]

Download as PDF Federal Register / Vol. 71, No. 26 / Wednesday, February 8, 2006 / Notices rmajette on PROD1PC67 with NOTICES1 Contact Person: Martin L. Padarathsingh, PhD., Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 6212, MSC 7804, Bethesda, MD 20892. (301) 435–1717. padaratm@csr.nih.gov. Name of Committee: Center for Scientific Review Special Emphasis Panel, ZRG1 IDM– Q (04): Leishmania and Trypanosoma Biology. Date: February 28, 2006. Time: 1 p.m. to 4 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892. (Telephone Conference Call). Contact Person: Rossana Berti, PhD., Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 3015–G, MSC 7846, Bethesda, MD 20892. 301–402– 6411. bertiros@csr.nih.gov. Name of Committee: Center for Scientific Review Special Emphasis Panel, Research Partnership for Improving Functional Outcome PAR–04–077. Date: February 28, 2006. Time: 2 p.m. to 4 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892. (Virtual Meeting). Contact Person: Seetha Bhagavan, PhD., Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 1126, MSC 7846, Bethesda, MD 20892. (301) 435– 1121. bhagavas@csr.nih.gov. Name of Committee: Center for Scientific Review Special Emphasis Panel, BDCN Bioengineering Research Partnerships. Date: February 28, 2006. Time: 2 p.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Washington Doubletree Hotel, 1515 Rhode Island Ave., NW., Washington, DC 20005. Contact Person: Vinod Charles, PhD., Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5196, MSC 7846, Bethesda, MD 20892. 301–435– 0902. charlesvi@csr.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393–93.396, 93.837–93.844, 93.846–93.878, 93.892, 93.893, National Institutes of Health, HHS) Dated: January 13, 2006 Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 06–1139 Filed 2–7–06; 8:45 am] BILLING CODE 4140–01–M VerDate Aug<31>2005 15:26 Feb 07, 2006 Jkt 208001 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of Exclusive License: Food Quality Indicator Device National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 CFR 404.7(a)(1)(i), that the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an exclusive patent license to practice the inventions embodied in the JP patent application H11–507724, filed 16 July 1998, to MBL, Co., Ltd., located in Nagoya-shi, Japan. The prospective exclusive license territory may be Japan and the field of use may be limited to the development, manufacturing and sales of the food indicator devise. DATES: Only written comments and/or application for a license which are received by the National Institutes of Health on or before April 10, 2006 will be considered. ADDRESSES: Requests for copies of the patent, inquiries, comments and other materials relating to the contemplated exclusive license should be directed to: George G. Pipia, PhD., Technology Licensing Specialist, Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852–3804; Telephone: (301) 435–5560; Facsimile: (301) 402–0220; E-mail: pipiag@mail.nih.gov. SUPPLEMENTARY INFORMATION: The prospective exclusive license will be royalty bearing and will comply with the terms and conditions of 35 U.S.C. 209(c)(1) and 37 CFR 404.7(a)(1)(i). The prospective exclusive license may be granted unless within sixty (60) days from the date of this published notice, the NIH receives written evidence and argument that establish that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR 404.7. Description of the Technology E–093–1997/0: Scientists at the U.S. Food and Drug Administration have invented an effective way to monitor food quality and freshness in real time. The major factor for food spoilage is the release of volatile gases due to the action of enzymes contained within the food or produced by microorganisms, such as bacteria, yeasts and molds growing in the food. The rate of release PO 00000 Frm 00071 Fmt 4703 Sfmt 4703 6515 of such gases depends on food’s storage history. In this technology, a reactive dye locked in a water-repellent material reacts with the gases released during food decomposition and changes color. Thus a rapid and informed decision can be made about quality of food and its shelf life under the storage conditions used. Since the detection is based on biological processes that are the root cause for food spoilage, these indicators are much more reliable. This technology provides an excellent alternative to the current methods for assessing food quality that cannot accurately estimate shelf life of food products due to unreliable storage history. This technology is also much less expensive than the current methods. These indicators have been successfully tested on seafood and meats and can be easily adapted to dairy products. This product is fully developed and is ready for full commercial rollout. Applications for a license in the field of use filed in response to this notice will be treated as objections to the grant of the contemplated exclusive license. Comments and objections submitted to this notice will not be made available for public inspection and, to the extent permitted by law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. Dated: February 1, 2006. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E6–1650 Filed 2–7–06; 8:45 am] BILLING CODE 4160–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of Exclusive License: Aminoflavone Compounds as Anti-Cancer Agents National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 CFR 404.7(a)(1)(i), that the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an exclusive patent license to practice the inventions embodied in the (1) U.S. Provisional Patent Application 60/195,507, filed April 6, 2000, entitled ‘‘Aminoflavone Compounds, Compositions, and E:\FR\FM\08FEN1.SGM 08FEN1 6516 Federal Register / Vol. 71, No. 26 / Wednesday, February 8, 2006 / Notices Methods of Use Thereof’’ and all related foreign patents/patent applications (HHS Ref. No. E–279–1999/0); (2) U.S. Patent Application 08/ 014,696, filed February 8, 1993, entitled ‘‘5-Aminoflavone Derivatives’’ and all related foreign patents/patent applications (HHS Ref. No. E–296–2005/ 1); (3) PCT Patent Application PCT/ US96/00181, filed August 10, 1994, entitled ‘‘5-Aminoflavone Derivatives, Their Preparation and Their Use as Antibacterial, Anti-estrogenic and/or Antitumor Agent’’ and all related foreign patents/patent applications (HHS Ref. No. E–295–2005/0), with the exception of the JP patent application JP204356/93, filed on August 18, 1993; to Tigris Pharmaceuticals, Inc. located in New York, NY. The patent rights in these inventions have been assigned to the United States of America. The prospective exclusive license territory may be worldwide and the field of use may be limited to human pharmaceutical uses of aminoflavone compounds as anti-cancer agents. DATES: Only written comments and/or license applications which are received by the National Institutes of Health on or before April 10, 2006 will be considered. Requests for copies of the patent, inquiries, comments and other materials relating to the contemplated exclusive license should be directed to: George G. Pipia, PhD., Technology Licensing Specialist, Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852–3804; Telephone: (301) 435–5560; Facsimile: (301) 402–0220; E-mail: pipiag@mail.nih.gov. ADDRESSES: The prospective exclusive license will be royalty bearing and will comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR 404.7. The prospective exclusive license may be granted unless within sixty (60) days from the date of this published notice, the NIH receives written evidence and argument that establish that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR 404.7. SUPPLEMENTARY INFORMATION: rmajette on PROD1PC67 with NOTICES1 Description of the Technology E–279–1999/0: This invention is related to aminoflavone compounds with pharmaceutically acceptable properties, claiming pharmaceutical compositions and a method of inhibiting tumor growth. The invention improves the pharmaceutical property VerDate Aug<31>2005 15:26 Feb 07, 2006 Jkt 208001 of aminoflavone compounds. The present invention addresses these problems by providing a method of producing water-soluble analogues of water-insoluble drugs. In particular, the present invention describes novel analogues derived from 5-aminoflavone (TK2339) compounds. These derivatives have shown good differential activity in the NCI 60-cell line in vitro cancer drug screen with potent and selective cytotoxicity against CAKI–1 and A498 renal, MCF–7 breast, and OVCAR–5 ovarian carcinoma cell lines. In addition, these derivatives have shown in vivo activity against CAKI–1 and A498 renal carcinoma xenographs. The novel compounds display improved solubility in aqueous solutions over the parent compounds (see below) without sacrificing potent antitumor activity. Since these compounds possess very favorable pharmaceutical properties, they have greater potential to be useful in the treatment of human cancers. The claims of the issued patent or pending patent applications of this patent family are directed to compositions comprising aminoflavone derivatives and to methods of their use. E–296–2005/0 and E–296–2005/1: These two inventions describe 5aminoflavone derivatives, having antibacterial, anti-estrogenic and anticancer activity. These inventions constitute earlier, parent 5aminoflavone compounds, which have inferior solubility in aqueous solutions compared to new compounds outlined in E–279–1999/0 technology. Applications for a license in the field of use filed in response to this notice will be treated as objections to the grant of the contemplated exclusive license. Comments and objections submitted to this notice will not be made available for public inspection and, to the extent permitted by law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. Dated: January 30, 2006. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E6–1651 Filed 2–7–06; 8:45 am] BILLING CODE 4140–01–P PO 00000 Frm 00072 Fmt 4703 Sfmt 4703 DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG–2006–23736] Collection of Information Under Review by Office of Management and Budget: OMB Control Numbers 1625– 0047, 1625–0063, 1625–0070, and 1625–0084 Coast Guard, DHS. Request for comments. AGENCY: ACTION: SUMMARY: In compliance with the Paperwork Reduction Act of 1995, the U.S. Coast Guard intends to seek the approval of OMB for the renewal of four Information Collection Requests (ICRs). The ICRs are: (1) 1625–0047, Plan Review and Records for Vital System Automation; (2) 1625–0063, Marine Occupational Health and Safety Standards for Benzene—46 CFR 197 Subpart C; (3) 1625–0070, Vessel Identification System; and (4) 1625– 0084, Audit Reports under the International Safety Management Code. Before submitting the ICRs to OMB, the Coast Guard is inviting comments on them as described below. DATES: Comments must reach the Coast Guard on or before April 10, 2006. ADDRESSES: To make sure that your comments and related material do not enter the docket [USCG–2006–23736] more than once, please submit them by only one of the following means: (1) By mail to the Docket Management Facility, U.S. Department of Transportation (DOT), room PL–401, 400 Seventh Street, SW., Washington, DC 20590–0001. (2) By delivery to room PL–401 on the Plaza level of the Nassif Building, 400 Seventh Street, SW., Washington, DC, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. The telephone number is 202–366– 9329. (3) By fax to the Docket Management Facility at 202–493–2251. (4) Electronically through the Web Site for the Docket Management System at https://dms.dot.gov. The Docket Management Facility maintains the public docket for this notice. Comments and material received from the public, as well as documents mentioned in this notice as being available in the docket, will become part of this docket and will be available for inspection or copying at room PL–401 on the Plaza level of the Nassif Building, 400 Seventh Street, SW., Washington, DC, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. E:\FR\FM\08FEN1.SGM 08FEN1

Agencies

[Federal Register Volume 71, Number 26 (Wednesday, February 8, 2006)]
[Notices]
[Pages 6515-6516]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E6-1651]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of Exclusive License: Aminoflavone Compounds as 
Anti-Cancer Agents

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 
CFR 404.7(a)(1)(i), that the National Institutes of Health, Department 
of Health and Human Services, is contemplating the grant of an 
exclusive patent license to practice the inventions embodied in the
    (1) U.S. Provisional Patent Application 60/195,507, filed April 6, 
2000, entitled ``Aminoflavone Compounds, Compositions, and

[[Page 6516]]

Methods of Use Thereof'' and all related foreign patents/patent 
applications (HHS Ref. No. E-279-1999/0);
    (2) U.S. Patent Application 08/014,696, filed February 8, 1993, 
entitled ``5-Aminoflavone Derivatives'' and all related foreign 
patents/patent applications (HHS Ref. No. E-296-2005/1);
    (3) PCT Patent Application PCT/US96/00181, filed August 10, 1994, 
entitled ``5-Aminoflavone Derivatives, Their Preparation and Their Use 
as Antibacterial, Anti-estrogenic and/or Antitumor Agent'' and all 
related foreign patents/patent applications (HHS Ref. No. E-295-2005/
0), with the exception of the JP patent application JP204356/93, filed 
on August 18, 1993;

to Tigris Pharmaceuticals, Inc. located in New York, NY. The patent 
rights in these inventions have been assigned to the United States of 
America.
    The prospective exclusive license territory may be worldwide and 
the field of use may be limited to human pharmaceutical uses of 
aminoflavone compounds as anti-cancer agents.

DATES: Only written comments and/or license applications which are 
received by the National Institutes of Health on or before April 10, 
2006 will be considered.

ADDRESSES: Requests for copies of the patent, inquiries, comments and 
other materials relating to the contemplated exclusive license should 
be directed to: George G. Pipia, PhD., Technology Licensing Specialist, 
Office of Technology Transfer, National Institutes of Health, 6011 
Executive Boulevard, Suite 325, Rockville, MD 20852-3804; Telephone: 
(301) 435-5560; Facsimile: (301) 402-0220; E-mail: pipiag@mail.nih.gov.

SUPPLEMENTARY INFORMATION: The prospective exclusive license will be 
royalty bearing and will comply with the terms and conditions of 35 
U.S.C. 209 and 37 CFR 404.7. The prospective exclusive license may be 
granted unless within sixty (60) days from the date of this published 
notice, the NIH receives written evidence and argument that establish 
that the grant of the license would not be consistent with the 
requirements of 35 U.S.C. 209 and 37 CFR 404.7.

Description of the Technology

    E-279-1999/0: This invention is related to aminoflavone compounds 
with pharmaceutically acceptable properties, claiming pharmaceutical 
compositions and a method of inhibiting tumor growth. The invention 
improves the pharmaceutical property of aminoflavone compounds. The 
present invention addresses these problems by providing a method of 
producing water-soluble analogues of water-insoluble drugs. In 
particular, the present invention describes novel analogues derived 
from 5-aminoflavone (TK2339) compounds. These derivatives have shown 
good differential activity in the NCI 60-cell line in vitro cancer drug 
screen with potent and selective cytotoxicity against CAKI-1 and A498 
renal, MCF-7 breast, and OVCAR-5 ovarian carcinoma cell lines. In 
addition, these derivatives have shown in vivo activity against CAKI-1 
and A498 renal carcinoma xenographs.
    The novel compounds display improved solubility in aqueous 
solutions over the parent compounds (see below) without sacrificing 
potent antitumor activity. Since these compounds possess very favorable 
pharmaceutical properties, they have greater potential to be useful in 
the treatment of human cancers. The claims of the issued patent or 
pending patent applications of this patent family are directed to 
compositions comprising aminoflavone derivatives and to methods of 
their use.
    E-296-2005/0 and E-296-2005/1: These two inventions describe 5-
aminoflavone derivatives, having antibacterial, anti-estrogenic and 
anti-cancer activity. These inventions constitute earlier, parent 5-
aminoflavone compounds, which have inferior solubility in aqueous 
solutions compared to new compounds outlined in E-279-1999/0 
technology.
    Applications for a license in the field of use filed in response to 
this notice will be treated as objections to the grant of the 
contemplated exclusive license. Comments and objections submitted to 
this notice will not be made available for public inspection and, to 
the extent permitted by law, will not be released under the Freedom of 
Information Act, 5 U.S.C. 552.

    Dated: January 30, 2006.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. E6-1651 Filed 2-7-06; 8:45 am]
BILLING CODE 4140-01-P
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