State-of-the-Science Conference: Cesarean Delivery on Maternal Request; Notice, 5346-5347 [E6-1272]
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Federal Register / Vol. 71, No. 21 / Wednesday, February 1, 2006 / Notices
affects up to twenty percent (20%) of
women during their reproductive years.
Endometriosis is characterized by the
growth of endometrial tissue outside the
uterus. This growth of tissue causes
recurring severe pain and can lead to
infertility. As the current procedure
used for diagnosis is invasive and not
entirely accurate, there is a need for a
fast, accurate, and minimally invasive
test to test for endometriosis.
Using DNA microarray analysis of
blood lymphocytes, the inventors have
identified two gene markers expressed
in blood that are able to discriminate
between those women who have
endometriosis and those that don’t. This
new technology would be minimally
invasive and quick using a blood sample
from a patient.
The prospective exclusive license will
be royalty-bearing and will comply with
the terms and conditions of 35 U.S.C.
209 and 37 CFR 404.7. The prospective
exclusive license may be granted unless,
within 60 days from the date of this
published Notice, the NIH receives
written evidence and argument that
establishes that the grant of the license
would not be consistent with the
requirements of 35 U.S.C. 209 and 37
CFR 404.7.
Properly filed competing applications
for a license filed in response to this
notice will be treated as objections to
the contemplated license. Comments
and objections submitted in response to
this notice will not be made available
for public inspection, and, to the extent
permitted by law, will not be released
under the Freedom of Information Act,
5 U.S.C. 552.
Dated: January 23, 2006.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E6–1277 Filed 1–31–06; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions;
Availability for Licensing
National Institutes of Health,
Public Health Service, HHS.
ACTION: Notice.
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AGENCY:
SUMMARY: The inventions listed below
are owned by an agency of the U.S.
Government and are available for
licensing in the U.S. in accordance with
35 U.S.C. 207 to achieve expeditious
commercialization of results of
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17:49 Jan 31, 2006
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federally-funded research and
development. Foreign patent
applications are filed on selected
inventions to extend market coverage
for companies and may also be available
for licensing.
Licensing information and
copies of the U.S. patent applications
listed below may be obtained by writing
to the indicated licensing contact at the
Office of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville,
Maryland 20852–3804; telephone: 301/
496–7057; fax: 301/402–0220. A signed
Confidential Disclosure Agreement will
be required to receive copies of the
patent applications.
ADDRESSES:
Rapid Anti-Depressant Response
Produced by Low Dose Treatment with
Anti-Muscarinic Drugs
Maura Furey and Wayne Drevets
(NIMH).
U.S. Patent Application No. 11/137,114
filed 25 May 2005 (HHS Reference
No. E–175–2004/0–US–01).
Licensing Contact: Norbert Pontzer; 301/
435–5502; pontzern@mail.nih.gov.
Available for licensing are new
methods of rapidly treating depression.
The drugs currently used to treat
depression work by increasing the
activity at serotonin, norepinephrine
and perhaps dopamine receptors in the
CNS. However these drugs are effective
in only 60–70% of patients, require 3–
4 weeks of treatment before clinical
improvement and have many side
effects. These inventors have shown that
in human patients, the administration of
anti-muscarinic agents produces a rapid,
prolonged alleviation of depressive
symptoms. Beginning the day following
administration of the anti-muscarinic
agent, a majority of patients show
significant improvements in mood,
anxiety, sleep and other depressive
symptoms that last days or weeks. The
very slow dissociation of some
muscarinic agents from their receptors
may account for the prolonged
therapeutic effects.
In addition to licensing, the
technology is available for further
development through collaborative
research opportunities with the
inventors.
Dated: January 23, 2006.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E6–1286 Filed 1–31–06; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
State-of-the-Science Conference:
Cesarean Delivery on Maternal
Request; Notice
Notice is hereby given of the National
Institutes of Health (NIH) ‘‘State-of-theScience Conference: Cesarean Delivery
on Maternal Request’’ to be held March
27–29, 2006, in the NIH Natcher
Conference Center, 45 Center Drive,
Bethesda, Maryland 20892. The
conference will begin at 8:30 a.m. on
March 27 and 28, and at 9 a.m. on
March 29, and will be open to the
public.
Despite the national goal of reducing
rates of cesarean delivery to 15 percent
of births established as part of Healthy
People 2010, cesarean delivery rates
have continued to increase. In 2003, 1.1
million or 27.5 percent of births in the
U.S. were by cesarean delivery. An
estimated 2.5 percent of births that year
were cesarean deliveries performed on
request, in the absence of medical
necessity, and the rate of cesareans on
request appears to be growing rapidly
over time.
The potential benefits of elective
cesarean delivery as compared to
vaginal delivery are not fully
understood but are thought to include
decreased risk of urinary incontinence,
pelvic organ prolapse, anal sphincter
damage and fecal incontinence. Elective
cesarean delivery also has the benefit of
flexible timing for mother and
physician. However, like any major
surgical procedure, there are risks
associated with cesarean delivery. Risks
that are known to be higher for cesarean
deliveries than for vaginal delivery
include adverse reactions to anesthesia,
breathing problems, bleeding, infection,
urinary tract injury, and injury to the
baby. In addition, recovery time
following cesarean delivery is typically
longer than for vaginal delivery.
Given these risks, any decision to
deliver by cesarean delivery when
vaginal delivery is also available should
be informed by the best possible
information regarding potential health
outcomes, good and bad, for both
mother and baby. Toward that end, the
National Institute of Child Health and
Human Development and the Office of
Medical Applications of Research of the
National Institutes of Health will
convene a State-of-the-Science
Conference from March 27 to 29, 2006,
to assess the available scientific
evidence relevant to the following
questions:
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Federal Register / Vol. 71, No. 21 / Wednesday, February 1, 2006 / Notices
• What is the trend and incidence of
cesarean delivery over time in the
United States and in other countries?
• What are the short-term (under one
year) and long-term benefits and harms
to mother and baby associated with
cesarean by request versus attempted
vaginal delivery?
• What factors influence benefits and
harms?
• What future research directions
need to be considered to get evidence
for making appropriate decisions
regarding cesarean on request or
attempted vaginal delivery?
An impartial, independent panel will
be charged with reviewing the available
published literature in advance of the
conference, including a systematic
literature review commissioned through
the Agency for Healthcare Research and
Quality. The first day and a half of the
conference will consist of presentations
by expert researchers and practitioners,
and public discussions. On Wednesday,
March 29, the panel will present a
statement of its collective assessment of
the evidence to answer each of the
questions above. The panel will also
hold a press conference to address
questions from the media. The draft
statement will be published online later
that day, and the final version will be
released approximately six weeks later.
The primary sponsors of this meeting
are the National Institute of Child
Health and Human Development and
the NIH Office of Medical Applications
of Research.
Advance information about the
conference and conference registration
materials may be obtained from
American Institutes for Research of
Silver Spring, Maryland, by calling 888–
644–2667, or by sending e-mail to
consensus@mail.nih.gov. American
Institutes for Research’s mailing address
is 10720 Columbia Pike, Silver Spring,
MD 20901. Registration information is
also available on the NIH Consensus
Development Program Web site at
https://consensus.nih.gov.
cchase on PROD1PC60 with NOTICES
Please Note: The NIH has recently
instituted new security measures to ensure
the safety of NIH employees and property.
All visitors must be prepared to show a photo
ID upon request. Visitors may be required to
pass through a metal detector and have bags,
backpacks, or purses inspected or x-rayed as
they enter NIH buildings. For more
information about the new security measures
at NIH, please visit the Web site at https://
www.nih.gov/about/visitorsecurity.htm.
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institutes of Health
National Cancer Institute; Notice of
Closed Meeting
National Cancer Institute; Notice of
Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The contract proposals and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the contract
proposals, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Cancer
Institute Special Emphasis Panel, SBIR Topic
204, ‘‘Plant Genomic Models for Establishing
Physiological Relevance of Bioactive
Components as Cancer Protectants’’.
Date: March 9, 2006.
Time: 10:15 a.m. to 11:30 a.m.
Agenda: To review and evaluate contract
proposals.
Place: National Institutes of Health, 6116
Executive Boulevard, Rockville, MD 20852,
(Telephone Conference Call).
Contact Person: Marvin L. Salin, PhD,
Scientific Review Administrator, Special
Review and Logistics Branch, Division of
Extramural Activities, 6116 Executive
Boulevard, Room 7073, MSC8329, Bethesda,
MD 20892–8329, 301–496–0694,
msalin@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.392, Cancer Construction;
93.393, Cancer Cause and Prevention
Research; 93.394, Cancer Detection and
Diagnosis Research; 93.395, Cancer
Treatment Research; 93.396, Cancer Biology
Research; 93.397, Cancer Centers Support;
93.398, Cancer Research Manpower; 93.399,
Cancer Control, National Institutes of Health,
HHS)
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
562b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The contract proposals and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the contract
proposals, the the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Cancer
Institute Special Emphasis Panel, SBIR Topic
220, ‘‘Chemical Optomization and StructureActivity Relationship’’.
Date: March 9, 2006.
Time: 11:45 a.m. to 1:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6116
Executive Boulevard, Rockville, MD 20852,
(Telephone Conference Call).
Contact Person: Marvin L. Salin, PhD,
Scientific Review Administrator, Special
Review and Logistics Branch, Division of
Extramural Activities, 6116 Executive
Boulevard, Room 7073, MSC8329, Bethesda,
MD 20892–8329, 301–496–0694,
msalin@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.392, Cancer Construction;
93.393, Cancer Cause and Prevention
Research; 93.394, Cancer Detection and
Diagnosis Research; 93.395, Cancer
Treatment Research; 93.396, Cancer Biology
Research; 93.397, Cancer Centers Support;
93.398, Cancer Research Manpower; 93.399,
Cancer Control, National Institutes of Health,
HHS)
Dated: January 24, 2006.
Anna Snouffer,
Acting Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 06–912 Filed 1–31–06; 8:45 am]
Dated: January 24, 2006.
Anna Snouffer,
Acting Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 06–910 Filed 1–31–06; 8:45 am]
BILLING CODE 4140–01–M
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National Institutes of Health
Dated: January 24, 2006.
Raynard S. Kington,
Deputy Director, National Institutes of Health.
[FR Doc. E6–1272 Filed 1–31–06; 8:45 am]
17:49 Jan 31, 2006
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Cancer Institute; Notice of
Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
BILLING CODE 4140–01–P
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5347
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]]>Agencies
[Federal Register Volume 71, Number 21 (Wednesday, February 1, 2006)]
[Notices]
[Pages 5346-5347]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E6-1272]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
State-of-the-Science Conference: Cesarean Delivery on Maternal
Request; Notice
Notice is hereby given of the National Institutes of Health (NIH)
``State-of-the-Science Conference: Cesarean Delivery on Maternal
Request'' to be held March 27-29, 2006, in the NIH Natcher Conference
Center, 45 Center Drive, Bethesda, Maryland 20892. The conference will
begin at 8:30 a.m. on March 27 and 28, and at 9 a.m. on March 29, and
will be open to the public.
Despite the national goal of reducing rates of cesarean delivery to
15 percent of births established as part of Healthy People 2010,
cesarean delivery rates have continued to increase. In 2003, 1.1
million or 27.5 percent of births in the U.S. were by cesarean
delivery. An estimated 2.5 percent of births that year were cesarean
deliveries performed on request, in the absence of medical necessity,
and the rate of cesareans on request appears to be growing rapidly over
time.
The potential benefits of elective cesarean delivery as compared to
vaginal delivery are not fully understood but are thought to include
decreased risk of urinary incontinence, pelvic organ prolapse, anal
sphincter damage and fecal incontinence. Elective cesarean delivery
also has the benefit of flexible timing for mother and physician.
However, like any major surgical procedure, there are risks associated
with cesarean delivery. Risks that are known to be higher for cesarean
deliveries than for vaginal delivery include adverse reactions to
anesthesia, breathing problems, bleeding, infection, urinary tract
injury, and injury to the baby. In addition, recovery time following
cesarean delivery is typically longer than for vaginal delivery.
Given these risks, any decision to deliver by cesarean delivery
when vaginal delivery is also available should be informed by the best
possible information regarding potential health outcomes, good and bad,
for both mother and baby. Toward that end, the National Institute of
Child Health and Human Development and the Office of Medical
Applications of Research of the National Institutes of Health will
convene a State-of-the-Science Conference from March 27 to 29, 2006, to
assess the available scientific evidence relevant to the following
questions:
[[Page 5347]]
What is the trend and incidence of cesarean delivery over
time in the United States and in other countries?
What are the short-term (under one year) and long-term
benefits and harms to mother and baby associated with cesarean by
request versus attempted vaginal delivery?
What factors influence benefits and harms?
What future research directions need to be considered to
get evidence for making appropriate decisions regarding cesarean on
request or attempted vaginal delivery?
An impartial, independent panel will be charged with reviewing the
available published literature in advance of the conference, including
a systematic literature review commissioned through the Agency for
Healthcare Research and Quality. The first day and a half of the
conference will consist of presentations by expert researchers and
practitioners, and public discussions. On Wednesday, March 29, the
panel will present a statement of its collective assessment of the
evidence to answer each of the questions above. The panel will also
hold a press conference to address questions from the media. The draft
statement will be published online later that day, and the final
version will be released approximately six weeks later.
The primary sponsors of this meeting are the National Institute of
Child Health and Human Development and the NIH Office of Medical
Applications of Research.
Advance information about the conference and conference
registration materials may be obtained from American Institutes for
Research of Silver Spring, Maryland, by calling 888-644-2667, or by
sending e-mail to consensus@mail.nih.gov. American Institutes for
Research's mailing address is 10720 Columbia Pike, Silver Spring, MD
20901. Registration information is also available on the NIH Consensus
Development Program Web site at https://consensus.nih.gov.
Please Note: The NIH has recently instituted new security
measures to ensure the safety of NIH employees and property. All
visitors must be prepared to show a photo ID upon request. Visitors
may be required to pass through a metal detector and have bags,
backpacks, or purses inspected or x-rayed as they enter NIH
buildings. For more information about the new security measures at
NIH, please visit the Web site at https://www.nih.gov/about/
visitorsecurity.htm.
Dated: January 24, 2006.
Raynard S. Kington,
Deputy Director, National Institutes of Health.
[FR Doc. E6-1272 Filed 1-31-06; 8:45 am]
BILLING CODE 4140-01-P
