National Toxicology Program (NTP); Center for the Evaluation of Risks to Human Reproduction (CERHR); Plans for Future Expert Panel Evaluations of Bisphenol A and Hydroxyurea; Request for Comments and Nominations of Scientists Qualified To Serve on These Expert Panels, 75827-75828 [E5-7617]

Download as PDF Federal Register / Vol. 70, No. 244 / Wednesday, December 21, 2005 / Notices DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel. Clinical Trial Planning Grant (R34). Date: January 3, 2006. Time: 4:50 p.m. to 6 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, One Democracy Plaza, 6701 Democracy Boulevard, Bethesda, MD 20892. (Telephone Conference Call). Contact Person: Yan Z. Wang, PhD., Scientific Review Administrator, National Institute of Arthritis and Musculoskeletal and Skin Diseases, 6701 Democracy Blvd., Suite 820, Bethesda, MD 20892, (301) 594–4957. wang1@mail.nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.846, Arthritis, Musculoskeletal and Skin Diseases Research, National Institutes of Health, HHS) Dated: December 14, 2005. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 05–24314 Filed 12–20–05; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES Name of Committee: Center for Scientific Review Special Emphasis Panel, Oncogenic Cooperation by Ets and AP1. Date: December 19, 2005. Time: 10 a.m. to 11 a.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Elaine Sierra-Rivera, PhD., Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 6184, MSC 7804, Bethesda, MD 20892, 301–435– 1779, riverase@csr.nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393–93.396, 93.837–93.844, 93.846–93.878, 93.892, 93.893, National Institutes of Health, HHS) Dated: December 12, 2005. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 05–24307 Filed 12–20–05; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Toxicology Program (NTP); Center for the Evaluation of Risks to Human Reproduction (CERHR); Plans for Future Expert Panel Evaluations of Bisphenol A and Hydroxyurea; Request for Comments and Nominations of Scientists Qualified To Serve on These Expert Panels Center for Scientific Review; Notice of Closed Meeting National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH). ACTION: Request for comments, nominations of scientific experts. Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice SUMMARY: The CERHR plans to convene two expert panels to evaluate the scientific evidence regarding the AGENCY: National Institutes of Health erjones on PROD1PC68 with NOTICES is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. VerDate Aug<31>2005 15:25 Dec 20, 2005 Jkt 208001 PO 00000 Frm 00048 Fmt 4703 Sfmt 4703 75827 potential reproductive and developmental toxicities of bisphenol A and hydroxyurea. Each expert panel will consist of approximately 12 scientists, selected for their expertise in various aspects of reproductive and developmental toxicology and other relevant areas of science. The CERHR invites the submission of public comments on these chemicals and the nomination of scientists to serve on the expert panels for their evaluation (see SUPPLEMENTARY INFORMATION below). These meetings are tentatively scheduled for late 2006, although the exact dates and locations have not yet been established. As plans are finalized, they will be announced in the Federal Register and posted on the NTP Web site (https://ntp-server.niehs.nih.gov). CERHR expert panel meetings are open to the public with time scheduled for oral public comment. Comments received by February 6, 2006 will be made available to the CERHR staff and the expert panels and posted on the CERHR Web site. Nominations of scientists received by February 6, 2006 will be considered for these panels and for inclusion in the CERHR Expert Registry. DATES: Correspondence should be sent to Dr. Michael D. Shelby, CERHR Director, NIEHS, P.O. Box 12233, MD EC–32, Research Triangle Park, NC 27709 (mail), (919) 541–3455 (telephone), (919) 316–4511 (fax), or shelby@niehs.nih.gov (e-mail). Courier address: CERHR, 79 T.W. Alexander Drive, Building 4401, Room 103, Research Triangle Park, NC 27709. ADDRESSES: SUPPLEMENTARY INFORMATION: Evaluation of Bisphenol A Bisphenol A (CAS RN: 80–05–7) is a high production volume chemical used in the production of epoxy resins, polyester resins, polysulfone resins, polyacrylate resins, polycarbonate plastics, and flame retardants. Polycarbonate plastics are used in food and drink packaging; the resins are used as lacquers to coat metal products such as food cans, bottle tops, and water supply pipes. Some polymers used in dental sealants and tooth coatings contain bisphenol A. Exposure to the general population can occur through direct contact or by exposure to food or drink that has been in contact with a material containing bisphenol A. CERHR selected this chemical for evaluation because of (1) High production volume, (2) widespread human exposure, (3) evidence of reproductive toxicity in laboratory animal studies, and (4) public concern. E:\FR\FM\21DEN1.SGM 21DEN1 75828 Federal Register / Vol. 70, No. 244 / Wednesday, December 21, 2005 / Notices Evaluation of Hydroxyurea Hydroxyurea (CAS RN: 127–07–1) is used in the treatment of cancer, sickle cell disease, and thalassemia. It is the only treatment for sickle cell disease used in children aside from blood transfusion. Hydroxyurea may be used in the treatment of children and adults with sickle cell disease for an extended period of time or for repeated cycles of therapy. Treatment with hydroxyurea may be associated with cytotoxic and myelosuppressive effects and hydroxyurea is mutagenic. This drug is used to treat sickle cell disease only if there is an indication of significant disease complications. CERHR selected this chemical for evaluation because of (1) increasing use in the treatment of sickle cell disease in children and adults, (2) knowledge that it inhibits DNA synthesis and is cytotoxic, and (3) published evidence of reproductive and developmental toxicity in rodents and humans. Request for Comments CERHR invites the public and other interested parties to submit information and comments on bisphenol A and hydroxyurea including toxicology information from completed and ongoing studies, information on planned studies, and information about current production levels, human exposure, use patterns, and environmental occurrence. erjones on PROD1PC68 with NOTICES Request for the Nomination of Scientists for Expert Panels CERHR invites nominations of qualified scientists to serve on the individual expert panels for (1) bisphenol A and (2) hydroxyurea. Panelists are primarily drawn from the CERHR Expert Registry and/or the nomination of other scientists who meet the criteria for listing in that registry which include: formal academic training and experience in a relevant scientific field, publications in peerreviewed journals, membership in relevant professional societies, and certification by an appropriate scientific board or other entities. Expert panel members are subject to applicable guidelines for conflict of interest in accordance with Federal Advisory Committee Act (5 U.S.C. Appendix 2). All panel members serve as individual experts and not as representatives of their employers or other organizations. Scientists on the expert panel will be selected to represent a wide range of expertise including, but not limited to, developmental toxicology, reproductive toxicology, epidemiology, general VerDate Aug<31>2005 15:25 Dec 20, 2005 Jkt 208001 toxicology, pharmacokinetics, exposure assessment, and biostatistics. Nominations should include contact information and a current curriculum vitae (if possible) and be forwarded to the CERHR at the address given above. Background Information on the CERHR The NTP established CERHR in June 1998 [Federal Register, December 14, 1998 (Volume 63, Number 239, page 68782)]. CERHR is a publicly accessible resource for information about adverse reproductive and developmental health effects associated with environmental and/or occupational exposures. Expert panels conduct scientific evaluations of environmental chemicals, drugs, physical agents, or mixtures selected by CERHR in public forums. CERHR invites the nomination of substances for expert panel evaluation or scientists for its expert registry. Information about CERHR and the nomination process can be obtained from its homepage (https:// cerhr.niehs.nih.gov) or by contacting Dr. Shelby (see ADDRESSES above). CERHR selects substances for evaluation based upon several factors including production volume, potential for human exposure from use and occurrence in the environment, extent of public concern, and extent of data from reproductive and developmental toxicity studies. CERHR follows a formal, multi-step process for review and evaluation of selected chemicals. The formal evaluation process was published in the Federal Register on July 16, 2001 (Volume 66, Number 136, pages 37047– 37048) and is available on the CERHR Web site under ‘‘About CERHR’’ or in printed copy from the CERHR. Dated: December 13, 2005. David A. Schwartz, Director, National Institute of Environmental Health Sciences and the National Toxicology Program. [FR Doc. E5–7617 Filed 12–20–05; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Extension of a Currently Approved Information Collection; Comment Request 30-Day Notice of Information Collection Under Review: Notice of Appeal of Decision under section 210 or ACTION: PO 00000 Frm 00049 Fmt 4703 Sfmt 4703 245A of the Immigration and Nationality Act; Form I–694. The Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) has submitted the following information collection request to the Office of Management and Budget (OMB) for review and clearance in accordance with the Paperwork Reduction Act of 1995. The information collection was previously published in the Federal Register on October 21, 2005, at 70 FR 61296, allowing for a 60-day public comment period. No comments were received by the USCIS on this proposed information collection. The purpose of this notice is to allow an additional 30 days for public comments. Comments are encouraged and will be accepted until January 20, 2006. This process is conducted in accordance with 5 CFR 1320.10. Written comments and/or suggestions regarding the item(s) contained in this notice, especially regarding the estimated public burden and associated response time, should be directed to the Department of Homeland Security (DHS), USCIS, Director, Regulatory Management Division, Clearance Office, 111 Massachusetts Avenue, 3rd floor, Washington, DC 20529. Comments may also be submitted to DHS via facsimile to 202–272–8352 or via e-mail at rfs.regs@dhs.gov. When submitting comments by e-mail please make sure to add OMB Control Number 1615–0034 in the subject box. Written comments and suggestions from the public and affected agencies should address one or more of the following four points: (1) Evaluate whether the proposed collection of information is necessary for the proper performance of the functions of the agency, including whether the information will have practical utility; (2) Evaluate the accuracy of the agencies estimate of the burden of the proposed collection of information, including the validity of the methodology and assumptions used; (3) Enhance the quality, utility, and clarity of the information to be collected; and (4) Minimize the burden of the collection of information on those who are to respond, including through the use of appropriate automated, electronic, mechanical, or other technological collection techniques or other forms of information technology, e.g., permitting electronic submission of responses. E:\FR\FM\21DEN1.SGM 21DEN1

Agencies

[Federal Register Volume 70, Number 244 (Wednesday, December 21, 2005)]
[Notices]
[Pages 75827-75828]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E5-7617]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES


National Toxicology Program (NTP); Center for the Evaluation of 
Risks to Human Reproduction (CERHR); Plans for Future Expert Panel 
Evaluations of Bisphenol A and Hydroxyurea; Request for Comments and 
Nominations of Scientists Qualified To Serve on These Expert Panels

AGENCY: National Institute of Environmental Health Sciences (NIEHS), 
National Institutes of Health (NIH).

ACTION: Request for comments, nominations of scientific experts.

-----------------------------------------------------------------------

SUMMARY: The CERHR plans to convene two expert panels to evaluate the 
scientific evidence regarding the potential reproductive and 
developmental toxicities of bisphenol A and hydroxyurea. Each expert 
panel will consist of approximately 12 scientists, selected for their 
expertise in various aspects of reproductive and developmental 
toxicology and other relevant areas of science. The CERHR invites the 
submission of public comments on these chemicals and the nomination of 
scientists to serve on the expert panels for their evaluation (see 
SUPPLEMENTARY INFORMATION below). These meetings are tentatively 
scheduled for late 2006, although the exact dates and locations have 
not yet been established. As plans are finalized, they will be 
announced in the Federal Register and posted on the NTP Web site 
(https://ntp-server.niehs.nih.gov). CERHR expert panel meetings are open 
to the public with time scheduled for oral public comment.

DATES: Comments received by February 6, 2006 will be made available to 
the CERHR staff and the expert panels and posted on the CERHR Web site. 
Nominations of scientists received by February 6, 2006 will be 
considered for these panels and for inclusion in the CERHR Expert 
Registry.

ADDRESSES: Correspondence should be sent to Dr. Michael D. Shelby, 
CERHR Director, NIEHS, P.O. Box 12233, MD EC-32, Research Triangle 
Park, NC 27709 (mail), (919) 541-3455 (telephone), (919) 316-4511 
(fax), or shelby@niehs.nih.gov (e-mail). Courier address: CERHR, 79 
T.W. Alexander Drive, Building 4401, Room 103, Research Triangle Park, 
NC 27709.

SUPPLEMENTARY INFORMATION:

Evaluation of Bisphenol A

    Bisphenol A (CAS RN: 80-05-7) is a high production volume chemical 
used in the production of epoxy resins, polyester resins, polysulfone 
resins, polyacrylate resins, polycarbonate plastics, and flame 
retardants. Polycarbonate plastics are used in food and drink 
packaging; the resins are used as lacquers to coat metal products such 
as food cans, bottle tops, and water supply pipes. Some polymers used 
in dental sealants and tooth coatings contain bisphenol A. Exposure to 
the general population can occur through direct contact or by exposure 
to food or drink that has been in contact with a material containing 
bisphenol A. CERHR selected this chemical for evaluation because of (1) 
High production volume, (2) widespread human exposure, (3) evidence of 
reproductive toxicity in laboratory animal studies, and (4) public 
concern.

[[Page 75828]]

Evaluation of Hydroxyurea

    Hydroxyurea (CAS RN: 127-07-1) is used in the treatment of cancer, 
sickle cell disease, and thalassemia. It is the only treatment for 
sickle cell disease used in children aside from blood transfusion. 
Hydroxyurea may be used in the treatment of children and adults with 
sickle cell disease for an extended period of time or for repeated 
cycles of therapy. Treatment with hydroxyurea may be associated with 
cytotoxic and myelosuppressive effects and hydroxyurea is mutagenic. 
This drug is used to treat sickle cell disease only if there is an 
indication of significant disease complications. CERHR selected this 
chemical for evaluation because of (1) increasing use in the treatment 
of sickle cell disease in children and adults, (2) knowledge that it 
inhibits DNA synthesis and is cytotoxic, and (3) published evidence of 
reproductive and developmental toxicity in rodents and humans.

Request for Comments

    CERHR invites the public and other interested parties to submit 
information and comments on bisphenol A and hydroxyurea including 
toxicology information from completed and ongoing studies, information 
on planned studies, and information about current production levels, 
human exposure, use patterns, and environmental occurrence.

Request for the Nomination of Scientists for Expert Panels

    CERHR invites nominations of qualified scientists to serve on the 
individual expert panels for (1) bisphenol A and (2) hydroxyurea. 
Panelists are primarily drawn from the CERHR Expert Registry and/or the 
nomination of other scientists who meet the criteria for listing in 
that registry which include: formal academic training and experience in 
a relevant scientific field, publications in peer-reviewed journals, 
membership in relevant professional societies, and certification by an 
appropriate scientific board or other entities. Expert panel members 
are subject to applicable guidelines for conflict of interest in 
accordance with Federal Advisory Committee Act (5 U.S.C. Appendix 2).
    All panel members serve as individual experts and not as 
representatives of their employers or other organizations. Scientists 
on the expert panel will be selected to represent a wide range of 
expertise including, but not limited to, developmental toxicology, 
reproductive toxicology, epidemiology, general toxicology, 
pharmacokinetics, exposure assessment, and biostatistics. Nominations 
should include contact information and a current curriculum vitae (if 
possible) and be forwarded to the CERHR at the address given above.

Background Information on the CERHR

    The NTP established CERHR in June 1998 [Federal Register, December 
14, 1998 (Volume 63, Number 239, page 68782)]. CERHR is a publicly 
accessible resource for information about adverse reproductive and 
developmental health effects associated with environmental and/or 
occupational exposures. Expert panels conduct scientific evaluations of 
environmental chemicals, drugs, physical agents, or mixtures selected 
by CERHR in public forums.
    CERHR invites the nomination of substances for expert panel 
evaluation or scientists for its expert registry. Information about 
CERHR and the nomination process can be obtained from its homepage 
(https://cerhr.niehs.nih.gov) or by contacting Dr. Shelby (see ADDRESSES 
above). CERHR selects substances for evaluation based upon several 
factors including production volume, potential for human exposure from 
use and occurrence in the environment, extent of public concern, and 
extent of data from reproductive and developmental toxicity studies.
    CERHR follows a formal, multi-step process for review and 
evaluation of selected chemicals. The formal evaluation process was 
published in the Federal Register on July 16, 2001 (Volume 66, Number 
136, pages 37047-37048) and is available on the CERHR Web site under 
``About CERHR'' or in printed copy from the CERHR.

    Dated: December 13, 2005.
David A. Schwartz,
Director, National Institute of Environmental Health Sciences and the 
National Toxicology Program.
[FR Doc. E5-7617 Filed 12-20-05; 8:45 am]
BILLING CODE 4140-01-P

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.