National Institute of Allergy and Infectious Diseases; Notice of Closed Meeting, 74830 [05-24120]
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74830
Federal Register / Vol. 70, No. 241 / Friday, December 16, 2005 / Notices
The human transmembrane
glycoprotein NMB (GPNMB) and a
splice variant form are highly expressed
in the cells of several forms of brain
cancer when compared to normal brain
cells. This invention combines
Pseudomonas exotoxin (PE) attached to
an Fv antibody fragment that targets
cells expressing GPNMB but not
GPNMB-negative or normal cells.
Results show that this antibodyimmunotoxin conjugate inhibits the
growth of cells expressing human
glycoprotein GPNMB, including
glioblastoma multiform cells, anaplastic
astrocytoma cells, anaplastic
oligodendroglioma cells and melanoma
cells.
Method of Screening for Hepatocellular
Carcinoma
Xin Wei Wang (NCI) et al.
U.S. Provisional Application filed (HHS
Reference No. E–333–2005/0–US–01).
Licensing Contact: David A.
Lambertson; 301–435–4632;
lambertsond@mail.nih.gov.
Hepatocellular Carcinoma (HCC) is a
common and aggressive cancer with a
high mortality rate. The high mortality
rate stems from an inability to diagnose
the cancer in patients, due to the lack
of available biomarkers for HCC.
Currently, HCC is diagnosed by
measuring the levels of serum alphafetoprotein (AFP); however, AFP is not
always present in HCC tumors,
especially small tumors. As a result,
there is a need for improved diagnostic
tests for diagnosing HCC in subjects.
The instant technology relates to
efficient methods of detecting HCC by
using new biomarkers for HCC. The
overexpression of Gpc3, Mdk, SerpinI1,
PEG–10 and QP–C correlates with the
presence of HCC, even in small tumors,
and regardless of serum levels of AFP.
By comparing the expression levels of at
least three of these markers in subject
samples with their expression levels in
control samples, the presence of HCC
can be diagnosed. The method can also
be used to monitor the progression or
regression of HCC in a subject after the
initial diagnosis, or to identify
compounds having anti-HCC activity by
measuring the expression levels of
Gpc3, Mdk, SerpinI1, PEG–10 and QP–
C following the treatment of a sample
with test compounds. Current claims are
directed to methods for screening for
HCC in a sample, methods for
monitoring the progression or regression
of HCC in a subject, methods for
screening compounds as having antiHCC activity, and arrays/kits comprising
polynucleotide probes for detecting the
level of Gpc3, Mdk, SerpinI1, PEG–10
and QP–C mRNA expression.
VerDate Aug<31>2005
19:37 Dec 15, 2005
Jkt 208001
In addition to licensing, the
technology (in conjunction with serum
ELISA technologies) is available for
further development through
collaborative research opportunities
with the inventors.
Mouse Polyclonal Antibodies to KAI1
Mary Custer et al. (NCI).
HHS Reference No. E–264–2005/0—
Research Tool.
Licensing Contact: John Stansberry; 301/
435–5236, stansbej@mail.nih.gov.
The invention relates to polyclonal
antibodies to the mouse metastasis
suppressor gene KAI1. KAI1 is down
regulated in advanced stages of various
human epithelial malignancies. For
example, expression levels of KAI1 are
inversely correlated with the metastasis
potential of human prostate cancer. This
antibody would be useful in the
characterization of the normal function
of the KAI1 protein and it would be
useful in efforts to investigate KAI1 role
in metastasis suppression in
experimental animal models.
Dated: December 8, 2005.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E5–7411 Filed 12–15–05; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and
Infectious Diseases; Notice of Closed
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel, Hyperaccelerated Award/
Mechanisms in Immunomodulation Trials
(January 2006).
Date: January 3, 2006.
PO 00000
Frm 00072
Fmt 4703
Sfmt 4703
Time: 1 p.m. to 3 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6700B
Rockledge Drive, Bethesda, MD 20817,
(Telephone Conference Call).
Contact Person: Mercy R. PrabhuDas, PhD.,
Scientific Review Administrator, Scientific
Review Program, Division of Extramural
Activities, NIAID/NIH/DHHS, 6700B
Rockledge Drive, MSC 7616, Bethesda, MD
20892–7616, 301–451–2615,
mp457n@nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
and Transplantation Research; 93.856,
Microbiology and Infectious Diseases
Research, National Institutes of Health, HHS)
Dated: December 9, 2005.
Anna Snouffer,
Acting Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 05–24120 Filed 12–15–05; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute on Deafness and
Other Communication Disorders;
Notice of Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute on
Deafness and Other Communications
Disorders Special Emphasis Panel, NIDCD
P30 Research Core Center.
Date: January 11, 2006.
Time: 8 a.m. to 3 p.m.
Agenda: To review and evaluate grant
applications.
Place: Hyatt Regency Bethesda, One
Bethesda Metro Center, 7400 Wisconsin
Avenue, Bethesda, MD 20814.
Contact Person: Shiguang Yang, PhD,
DVM, Scientific Review Administrator,
Division of Extramural Activities, NIDCD,
NIH, 6120 Executive Blvd., Bethesda, MD
20892, 301–496–8683.
Name of Committee: National Institute on
Deafness and Other Communications
E:\FR\FM\16DEN1.SGM
16DEN1
Agencies
[Federal Register Volume 70, Number 241 (Friday, December 16, 2005)]
[Notices]
[Page 74830]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 05-24120]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and Infectious Diseases; Notice of
Closed Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice is hereby given of the following
meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Allergy and Infectious
Diseases Special Emphasis Panel, Hyperaccelerated Award/Mechanisms
in Immunomodulation Trials (January 2006).
Date: January 3, 2006.
Time: 1 p.m. to 3 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, 6700B Rockledge Drive,
Bethesda, MD 20817, (Telephone Conference Call).
Contact Person: Mercy R. PrabhuDas, PhD., Scientific Review
Administrator, Scientific Review Program, Division of Extramural
Activities, NIAID/NIH/DHHS, 6700B Rockledge Drive, MSC 7616,
Bethesda, MD 20892-7616, 301-451-2615, mp457n@nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.855,
Allergy, Immunology, and Transplantation Research; 93.856,
Microbiology and Infectious Diseases Research, National Institutes
of Health, HHS)
Dated: December 9, 2005.
Anna Snouffer,
Acting Director, Office of Federal Advisory Committee Policy.
[FR Doc. 05-24120 Filed 12-15-05; 8:45 am]
BILLING CODE 4140-01-M