Government-Owned Inventions; Availability for Licensing, 73781 [E5-7250]
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Federal Register / Vol. 70, No. 238 / Tuesday, December 13, 2005 / Notices
marketed under the tradename Gleevec.
Mitoxantrone is also used to treat
certain types of cancers and multiple
sclerosis. For all of these compounds
the FDA approved new and expanded
uses and there is intense interest in
determining whether and where each of
the compounds actually collects in the
body, and especially whether they are
taken up by the targeted tumor.
Traditional approaches to determine
drug uptake and retention have been
invasive. Advantages of using this
technology include: (1) Avoidance of
exposing patients to toxic drugs that
have no potential for benefit; (2) ability
to rapidly determine whether a given
tumor will be likely to respond to a
particular drug; and (3) the ability to
monitor the impact of various dosages,
schedules, and modulators for delivery,
in situ, at the actual tumor under
treatment conditions. Further, methods
to guide treatment of solid tumors, with
labeled taxanes, are also disclosed in the
present application.
Additional information may be found
in: Ravert et al., ‘‘Radiosynthesis of
[11C]paclitaxel,’’ J Label Compd and
Radiopharm, 2002, 45(6):471–477.
In addition to licensing, the
technology is available for further
development through collaborative
research opportunities with the
inventors.
Dated: December 1, 2005.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E5–7249 Filed 12–12–05; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes Of Health
Government-Owned Inventions;
Availability for Licensing
National Institutes of Health,
Public Health Service, HHS.
AGENCY:
ACTION:
Notice.
SUMMARY: The inventions listed below
are owned by an agency of the U.S.
Government and are available for
licensing in the U.S. in accordance with
35 U.S.C. 207 to achieve expeditious
commercialization of results of
federally-funded research and
development. Foreign patent
applications are filed on selected
inventions to extend market coverage
for companies and may also be available
for licensing.
VerDate Aug<31>2005
00:22 Dec 13, 2005
Jkt 208001
Licensing information and
copies of the U.S. patent applications
listed below may be obtained by writing
to the indicated licensing contact at the
Office of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville,
Maryland 20852–3804; telephone: 301–
496–7057; fax: 301–402–0220. A signed
Confidential Disclosure Agreement will
be required to receive copies of the
patent applications.
ADDRESSES:
Quantitative Assay of the Angiogenic
and Antiangiogenic Activity of a Test
Molecule
Steven K. Libutti (NCI).
U.S. Patent Application No. 11/014,472
filed 16 Dec 2004 (HHS Reference No.
E–152–2002/1–US–01).
Licensing Contact: Mojdeh Bahar; 301–
435–2950; baharm@mail.nih.gov.
The invention provides a method of
measuring the angiogenic or
antiangiogenic activity of a test
molecule. The method comprises
obtaining an embryonated fowl egg,
creating a window in the shell of the
fowl egg, such that the CAM membrane
is exposed, providing to a test region of
interest on the CAM a substrate,
administering to a vessel located in the
CAM a test molecule, administering to
a vessel located in the CAM a
fluorescent-labeled particle, such that
the fluorescent-labeled particle travels
through each vessel contained in the
test region of interest, removing the
substrate and the test region of interest
from the fowl egg, capturing a threedimensional image of the test region of
interest, wherein the three-dimensional
image comprises a plurality of pixels,
such that a fluorescent vascular density
(FVD) value can be assigned to the test
region of interest, and comparing the
FVD value of the test region of interest
with the FVD value of a control region
of interest that was prepared in the same
manner as the test region of interest but
without the administration of a test
molecule, such that the angiogenic or
antiangiogenic activity of the test
molecule is measured. A lower FVD
value of the test region of interest as
compared to the FVD value of the
control region of interest is indicative of
the test molecule being useful as an
inhibitor of angiogenesis. Conversely, a
higher FVD value of the test region of
interest as compared to the FVD value
of the control region of interest is
indicative of the test molecule being
useful as a stimulator of angiogenesis.
In addition to licensing, the
technology is available for further
development through collaborative
research opportunities with the
inventors.
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73781
Autotaxin: Motility Simulating Protein
Useful in Cancer Diagnosis and
Therapy
Mary Stracke, Lance Liotta, Elliot
Schiffman, Jerry Krutzch, and Jun
Murata (NCI).
U.S. Patent Application filed 16 Feb
2005 (HHS Reference No. E–142–
1990–2–US–05).
Licensing Contact: Mojdeh Bahar; 301–
435–2950; baharm@mail.nih.gov.
Cell motility plays an important role
in embryonic events, adult tissue
remodeling, wound healing and
metastasis of tumor cells. Some tumor
cells produce proteins termed
‘‘autocrine motility factors’’ that
stimulate motility in tumor cells. This
invention describes a novel tumor
protein called Autotaxin (‘‘ATX’’) that
stimulates both random and directed
migration of human A2058 melanoma
cells. ATX is a member of the
nucleotide phosphodiesterase and
pyrophosphatase (NPP) family of
proteins but is the only member of the
family that stimulates motility. It is also
the only member shown to possess
lysophospholipase D activity.
This invention can provide a
functional marker that can directly
estimate the invasive potential of a
particular human cancer. One could
also use this invention as an assay for
a particular secreted marker in body
fluids, or in tissues. Other uses include
the detection, diagnosis, and treatment
of human malignancies, and other
inflammatory, fibrotic, infectious and
healing disorders.
In addition to licensing, the
technology is available for further
development through collaborative
research opportunities with the
inventors.
Dated: December 1, 2005.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E5–7250 Filed 12–12–05; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Mental Health;
Notice of Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meetings.
The meetings will be closed to the
public in accordance with the
E:\FR\FM\13DEN1.SGM
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]]>Agencies
[Federal Register Volume 70, Number 238 (Tuesday, December 13, 2005)]
[Notices]
[Page 73781]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E5-7250]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes Of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-0220. A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
Quantitative Assay of the Angiogenic and Antiangiogenic Activity of a
Test Molecule
Steven K. Libutti (NCI).
U.S. Patent Application No. 11/014,472 filed 16 Dec 2004 (HHS Reference
No. E-152-2002/1-US-01).
Licensing Contact: Mojdeh Bahar; 301-435-2950; baharm@mail.nih.gov.
The invention provides a method of measuring the angiogenic or
antiangiogenic activity of a test molecule. The method comprises
obtaining an embryonated fowl egg, creating a window in the shell of
the fowl egg, such that the CAM membrane is exposed, providing to a
test region of interest on the CAM a substrate, administering to a
vessel located in the CAM a test molecule, administering to a vessel
located in the CAM a fluorescent-labeled particle, such that the
fluorescent-labeled particle travels through each vessel contained in
the test region of interest, removing the substrate and the test region
of interest from the fowl egg, capturing a three-dimensional image of
the test region of interest, wherein the three-dimensional image
comprises a plurality of pixels, such that a fluorescent vascular
density (FVD) value can be assigned to the test region of interest, and
comparing the FVD value of the test region of interest with the FVD
value of a control region of interest that was prepared in the same
manner as the test region of interest but without the administration of
a test molecule, such that the angiogenic or antiangiogenic activity of
the test molecule is measured. A lower FVD value of the test region of
interest as compared to the FVD value of the control region of interest
is indicative of the test molecule being useful as an inhibitor of
angiogenesis. Conversely, a higher FVD value of the test region of
interest as compared to the FVD value of the control region of interest
is indicative of the test molecule being useful as a stimulator of
angiogenesis.
In addition to licensing, the technology is available for further
development through collaborative research opportunities with the
inventors.
Autotaxin: Motility Simulating Protein Useful in Cancer Diagnosis and
Therapy
Mary Stracke, Lance Liotta, Elliot Schiffman, Jerry Krutzch, and Jun
Murata (NCI).
U.S. Patent Application filed 16 Feb 2005 (HHS Reference No. E-142-
1990-2-US-05).
Licensing Contact: Mojdeh Bahar; 301-435-2950; baharm@mail.nih.gov.
Cell motility plays an important role in embryonic events, adult
tissue remodeling, wound healing and metastasis of tumor cells. Some
tumor cells produce proteins termed ``autocrine motility factors'' that
stimulate motility in tumor cells. This invention describes a novel
tumor protein called Autotaxin (``ATX'') that stimulates both random
and directed migration of human A2058 melanoma cells. ATX is a member
of the nucleotide phosphodiesterase and pyrophosphatase (NPP) family of
proteins but is the only member of the family that stimulates motility.
It is also the only member shown to possess lysophospholipase D
activity.
This invention can provide a functional marker that can directly
estimate the invasive potential of a particular human cancer. One could
also use this invention as an assay for a particular secreted marker in
body fluids, or in tissues. Other uses include the detection,
diagnosis, and treatment of human malignancies, and other inflammatory,
fibrotic, infectious and healing disorders.
In addition to licensing, the technology is available for further
development through collaborative research opportunities with the
inventors.
Dated: December 1, 2005.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. E5-7250 Filed 12-12-05; 8:45 am]
BILLING CODE 4140-01-P
