Science Advisory Board Staff Office; Notification of Advisory Meeting of the SAB All-Ages Lead Model (AALM) Review Panel, 60077-60078 [05-20601]

Download as PDF Federal Register / Vol. 70, No. 198 / Friday, October 14, 2005 / Notices biological processes associated with the absorption, distribution, metabolism, and elimination of compounds. With the appropriate data, these models can be used to extrapolate across species and exposure scenarios, and address various sources of uncertainty in risk assessments. This report addresses the following questions: (1) Why do risk assessors need PBPK models; (2) How can these models be used in risk assessments; and (3) What are the characteristics of acceptable PBPK models for use in risk assessment? Dated: October 6, 2005. Peter Preuss, Director, National Center for Environmental Assessment. [FR Doc. 05–20600 Filed 10–13–05; 8:45 am] BILLING CODE 6560–50–P ENVIRONMENTAL PROTECTION AGENCY [FRL–7983–5] Science Advisory Board Staff Office; Notification of Advisory Meeting of the SAB All-Ages Lead Model (AALM) Review Panel Environmental Protection Agency (EPA). ACTION: Notice. AGENCY: SUMMARY: The Environmental Protection Agency (EPA or Agency) Science Advisory Board (SAB) Staff Office announces a public meeting of the SAB All-Ages Lead Model Review Panel (Panel) for the purpose of providing the Agency with advice and recommendations on the recentlydeveloped All-Ages Lead Model. DATES: The meeting will be held Thursday, October 27, 2005, from 9 a.m. to 5:30 p.m. (eastern time), and Friday, October 28, 2005, from 9 a.m. to 2 p.m. (eastern time). ADDRESSES: The meeting will take place at SAB Conference Center, 1025 F Street, NW., Suite 3700, Washington, DC 20004. FOR FURTHER INFORMATION CONTACT: Any member of the public who would like to submit written or brief oral comments (5 minutes or less), or wants further information concerning this meeting, may contact Mr. Fred Butterfield, Designated Federal Officer (DFO), EPA Science Advisory Board (1400F), U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue, NW., Washington, DC 20460; via telephone/ voice mail: (202) 343–9994; fax: (202) 233–0643; or e-mail at: butterfield.fred@epa.gov. General information concerning the EPA Science VerDate Aug<31>2005 13:54 Oct 13, 2005 Jkt 208001 Advisory Board can be found on the EPA Web site at: https://www.epa.gov/ sab. SAB and the AALM Review Panel: The SAB was established by 42 U.S.C. 4365 to provide independent scientific and technical advice, consultation, and recommendations to the EPA Administrator on the technical basis for Agency positions and regulations. The SAB is a Federal advisory committee chartered under the Federal Advisory Committee Act (FACA), as amended, 5 U.S.C., App. The Panel will provide advice through the chartered SAB, and will comply with the provisions of FACA and all appropriate SAB Staff Office procedural policies. The SAB Staff Office recently established the SAB AALM Review Panel to provide the EPA Administrator, through the SAB, with advice and recommendations on the Agency’s AllAges Lead Model. The Panel will comply with the provisions of FACA and all appropriate SAB Staff Office procedural policies. Background: The SAB Staff Office has formed this Panel at the request of EPA’s Office of Research and Development (ORD), National Center for Environmental Assessment (NCEA), to provide advice and recommendations to the Agency on EPA’s recentlydeveloped All-Ages Lead Model (AALM). The AALM is designed to predict lead concentrations in body tissues and organs for a hypothetical individual, based on a simulated lifetime of lead exposure. Statistical methods can be used to extrapolate to a population of similarly-exposed individuals. The precursor to the AALM was the Integrated Exposure Uptake Biokinetic (IEUBK) Model for Lead in Children. The IEUBK Model underwent peer review by the SAB in 1991 and was subsequently revised in response to that review, leading to release of Version 0.99d of the IEUBK Model in March 1994. Since then, the IEUBK Model has been widely accepted and used in the risk assessment community as a tool for implementing the site-specific risk assessment process when the issue is childhood lead exposure. Based on further refinement of the IEUBK Model and its expansion for use with additional age groups beyond pediatric populations 6 years old or younger, the AALM has recently been developed to cover older childhood and adult lead exposure. The anticipated outcome will be reduced uncertainty in lead exposure assessments for children and adults. Any questions concerning either the AALM or the IEUBK Model for Lead in SUPPLEMENTARY INFORMATION: PO 00000 Frm 00018 Fmt 4703 Sfmt 4703 60077 Children should be directed to Dr. Robert Elias, NCEA–RTP, at phone (919) 541–4167; or e-mail elias.robert@epa.gov. Availability of Meeting Materials: NCEA–RTP has posted the ‘‘All-Ages Lead Model (AALM) Version 1.05 (External Review Draft)’’ and related materials (including the Guidance Manual for the AALM Version 1.05) on the NCEA Web site at https:// cfpub.epa.gov/ncea/cfm/ recordisplay.cfm?deid=139314. Furthermore, the SAB Staff Office will post a copy of the final agenda and charge to the Panel for this advisory meeting on the SAB Web site at https://www.epa.gov/sab (under ‘‘Meeting Agendas’’) and https:// www.epa.gov/sab/panels/ ad_hoc_aalm_rev_panel.htm in advance of the Panel meeting. Procedures for Providing Public Comment: The SAB Staff Office accepts written public comments of any length, and will accommodate oral public comments whenever possible. The SAB Staff Office expects that public will not repeat previously-submitted oral or written statements. Oral Comments: Requests to provide oral comments must be in writing (e-mail, fax or mail) and received by Mr. Butterfield no later than October 20, 2005 to reserve time on the October 27, 2005 meeting agenda. Opportunities for oral comments will be limited to five minutes per speaker. Written Comments: Written comments should be received in the SAB Staff Office by October 21, 2005 so that the comments may be made available to the members of the members of the SAB AALM Review Panel for their consideration. Comments should be supplied to Mr. Butterfield at the contact information provided above, in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, Word, or Rich Text files (in IBM–PC/Windows 98/2000/XP format)). Those providing written comments and who attend the meeting in person are also asked to bring 75 copies of their comments for public distribution. Meeting: Individuals requiring special accommodation at this meeting, including wheelchair access to the conference room, should contact Mr. Butterfield at the phone number or email address noted above no later than October 20, 2005 so that appropriate arrangements can be made. E:\FR\FM\14OCN1.SGM 14OCN1 60078 Federal Register / Vol. 70, No. 198 / Friday, October 14, 2005 / Notices Dated: October 6, 2005. Anthony F. Maciorowski, Associate Director for Science, EPA Science Advisory Board Staff Office. [FR Doc. 05–20601 Filed 10–13–05; 8:45 am] pertaining to bioaccumulation of atrazine and alachlor). SUPPLEMENTARY INFORMATION: BILLING CODE 6560–50–P A. How Can I Get Copies of Related Information? 1. Docket. EPA has established an official public docket for this Notice under Docket ID Nos. OW–2005–0008 for Atrazine and OW–2005–0009 for Alachlor. The official public docket is the collection of materials that is available for public viewing at the Water Docket in the EPA Docket Center, EPA West, Room B102, 1301 Constitution Ave., NW., Washington, DC. Although a part of official docket, public docket does not include Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The telephone number for the Public Reading Room is (202) 566–1744, and the telephone number for the Water Docket is (202) 566–2426. 2. Electronic Access. You may access this Federal Register document electronically through the EPA Internet under the ‘‘Federal Register’’ listings at https://www.epa.gov/fedrgstr/. An electronic version of the public docket is available through EPA’s electronic public docket and comment system, EPA Dockets. You may use EPA Dockets at https://www.epa.gov/edocket/ to access the index listing of the contents of the official public docket and to access those documents in the public docket that are available electronically. Although not all docket materials may be available electronically, you may still access any of the publicly available docket materials through the docket facility identified in Section B.1. Once in the system, select ‘‘search,’’ then key in the appropriate docket identification number. ENVIRONMENTAL PROTECTION AGENCY [FRL–OW–FRL–7983–6] Notice of Data Availability and Request for Data and Information to Develop Ambient Water Quality Criteria for Protection of Human Health for Atrazine and Alachlor Environmental Protection Agency. ACTION: Notice of data availability; request for scientific data and information. AGENCY: SUMMARY: Section 304(a) of the Clean Water Act (CWA) requires the U.S. Environmental Protection Agency (EPA) to develop and publish, and from time to time revise, criteria for water accurately reflecting the latest scientific knowledge. Today, EPA is informing the public of data currently available to EPA and requesting data and information to develop Ambient Water Quality Criteria for Protection of Human Health for Atrazine and Alachlor. Lists of references available to the Agency for atrazine and alachlor will be posted on EPA’s Office of Science and Technology’s Home-page located at https://www.epa.gov/ost. In addition to seeking input on the references known to the Agency, EPA is also soliciting any additional pertinent data or information that may be useful in developing these criteria. DATES: Submit data and information on or before November 14, 2005. ADDRESSES: Data and information may be submitted electronically, by mail, or through hand deliver/courier. Follow the detailed instructions as provided in Unit B of the SUPPLEMENTARY INFORMATION section. FOR FURTHER INFORMATION CONTACT: Dr. Amal Mahfouz, U.S. Environmental Protection Agency, Office of Water, Health and Ecological Criteria Division (4304T), 1200 Pennsylvania Avenue, NW., Washington, DC 20460; (202) 566– 1114; Mahfouz.amal@epa.gov (Data on toxicity of atrazine and alachlor) or Dr. Tala Henry, U.S. Environmental Protection Agency, Office of Water, Health and Ecological Criteria Division (4304T), 1200 Pennsylvania Avenue, NW., Washington, DC 20460; (202) 566– 1323; henry.tala@epa.gov (Data VerDate Aug<31>2005 13:54 Oct 13, 2005 Jkt 208001 I. General Information B. How and to Whom Do I Submit Data and Information? You may submit data electronically, by mail, or through hand delivery/ courier. To ensure proper receipt by EPA, identify the appropriate docket identification number in the subject line on the first page. Please ensure that your data are submitted within the specified period. 1. Electronically. If you submit data as prescribed below, EPA recommends that you include your name, mailing address, and an e-mail address or other contact information. Also include this contact information on the outside of PO 00000 Frm 00019 Fmt 4703 Sfmt 4703 any disk or CD ROM you submit, and in any cover letter accompanying the disk or CD ROM. This ensures that you can be identified as the submitter of the data and allows EPA to contact you in case EPA cannot read your data due to technical difficulties or needs further information on the substance of your data. EPA’s policy is that EPA will not edit your data, and any identifying or contact information provided in the body of the data will be included as part of the data that is placed in the official public docket, and made available in EPA’s electronic public docket. If EPA cannot read your data due to technical difficulties and cannot contact you for clarification, EPA may not be able to consider your comment. i. EPA Dockets. Your use of EPA’s electronic public docket to submit data to EPA electronically is EPA’s preferred method for receiving data. Go directly to EPA Dockets at https://www.epa.gov/ edocket, and follow the online instructions. Once in the system, select ‘‘search,’’ and then key in Docket ID Nos. OW–2005–0008 for Atrazine or OW–2005–0009 for Alachlor. The system is an ‘‘anonymous access’’ system, which means EPA will not know your identity, e-mail address, or other contact information unless you provide it along with your data. ii. E-mail. Data may be sent by electronic mail (e-mail) to owdocket@epa.gov, Attention Docket ID Nos. OW–2005–0008 for Atrazine and OW–2005–0009 for Alachlor. In contrast to EPA’s electronic public docket, EPA’s e-mail system is not an ‘‘anonymous access’’ system. If you send an e-mail directly to the Docket without going through EPA’s electronic public docket, EPA’s e-mail system automatically captures your e-mail address. E-mail addresses that are automatically captured by EPA’s e-mail system are included as part of the comment that is placed in the official public docket, and made available in EPA’s electronic public docket. iii. Disk or CD ROM. You may submit data on a disk or CD ROM that you mail to the mailing address identified in Unit B.2. These electronic submissions will be accepted in WordPerfect or ASCII file format. Avoid the use of special characters and any form of encryption. 2. By Mail. Send an original and three copies of any data or information to: Water Docket, Environmental Protection Agency, Mailcode: 4101T, 1200 Pennsylvania Ave., NW., Washington, DC, 20460, Attention Docket ID Nos. OW–2005–0008 for Atrazine and OW– 2005–0009 for Alachlor. 3. By Hand Delivery or Courier. Deliver your comments to: EPA Docket E:\FR\FM\14OCN1.SGM 14OCN1

Agencies

[Federal Register Volume 70, Number 198 (Friday, October 14, 2005)]
[Notices]
[Pages 60077-60078]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 05-20601]


-----------------------------------------------------------------------

ENVIRONMENTAL PROTECTION AGENCY

[FRL-7983-5]


Science Advisory Board Staff Office; Notification of Advisory 
Meeting of the SAB All-Ages Lead Model (AALM) Review Panel

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The Environmental Protection Agency (EPA or Agency) Science 
Advisory Board (SAB) Staff Office announces a public meeting of the SAB 
All-Ages Lead Model Review Panel (Panel) for the purpose of providing 
the Agency with advice and recommendations on the recently-developed 
All-Ages Lead Model.

DATES: The meeting will be held Thursday, October 27, 2005, from 9 a.m. 
to 5:30 p.m. (eastern time), and Friday, October 28, 2005, from 9 a.m. 
to 2 p.m. (eastern time).

ADDRESSES: The meeting will take place at SAB Conference Center, 1025 F 
Street, NW., Suite 3700, Washington, DC 20004.

FOR FURTHER INFORMATION CONTACT: Any member of the public who would 
like to submit written or brief oral comments (5 minutes or less), or 
wants further information concerning this meeting, may contact Mr. Fred 
Butterfield, Designated Federal Officer (DFO), EPA Science Advisory 
Board (1400F), U.S. Environmental Protection Agency, 1200 Pennsylvania 
Avenue, NW., Washington, DC 20460; via telephone/voice mail: (202) 343-
9994; fax: (202) 233-0643; or e-mail at: butterfield.fred@epa.gov. 
General information concerning the EPA Science Advisory Board can be 
found on the EPA Web site at: https://www.epa.gov/sab.

SUPPLEMENTARY INFORMATION: SAB and the AALM Review Panel: The SAB was 
established by 42 U.S.C. 4365 to provide independent scientific and 
technical advice, consultation, and recommendations to the EPA 
Administrator on the technical basis for Agency positions and 
regulations. The SAB is a Federal advisory committee chartered under 
the Federal Advisory Committee Act (FACA), as amended, 5 U.S.C., App. 
The Panel will provide advice through the chartered SAB, and will 
comply with the provisions of FACA and all appropriate SAB Staff Office 
procedural policies.
    The SAB Staff Office recently established the SAB AALM Review Panel 
to provide the EPA Administrator, through the SAB, with advice and 
recommendations on the Agency's All-Ages Lead Model. The Panel will 
comply with the provisions of FACA and all appropriate SAB Staff Office 
procedural policies.
    Background: The SAB Staff Office has formed this Panel at the 
request of EPA's Office of Research and Development (ORD), National 
Center for Environmental Assessment (NCEA), to provide advice and 
recommendations to the Agency on EPA's recently-developed All-Ages Lead 
Model (AALM). The AALM is designed to predict lead concentrations in 
body tissues and organs for a hypothetical individual, based on a 
simulated lifetime of lead exposure. Statistical methods can be used to 
extrapolate to a population of similarly-exposed individuals. The 
precursor to the AALM was the Integrated Exposure Uptake Biokinetic 
(IEUBK) Model for Lead in Children. The IEUBK Model underwent peer 
review by the SAB in 1991 and was subsequently revised in response to 
that review, leading to release of Version 0.99d of the IEUBK Model in 
March 1994. Since then, the IEUBK Model has been widely accepted and 
used in the risk assessment community as a tool for implementing the 
site-specific risk assessment process when the issue is childhood lead 
exposure. Based on further refinement of the IEUBK Model and its 
expansion for use with additional age groups beyond pediatric 
populations 6 years old or younger, the AALM has recently been 
developed to cover older childhood and adult lead exposure. The 
anticipated outcome will be reduced uncertainty in lead exposure 
assessments for children and adults.
    Any questions concerning either the AALM or the IEUBK Model for 
Lead in Children should be directed to Dr. Robert Elias, NCEA-RTP, at 
phone (919) 541-4167; or e-mail elias.robert@epa.gov.
    Availability of Meeting Materials: NCEA-RTP has posted the ``All-
Ages Lead Model (AALM) Version 1.05 (External Review Draft)'' and 
related materials (including the Guidance Manual for the AALM Version 
1.05) on the NCEA Web site at https://cfpub.epa.gov/ncea/cfm/
recordisplay.cfm?deid=139314. Furthermore, the SAB Staff Office will 
post a copy of the final agenda and charge to the Panel for this 
advisory meeting on the SAB Web site at https://www.epa.gov/sab (under 
``Meeting Agendas'') and https://www.epa.gov/sab/panels/ad_hoc_aalm_
rev_panel.htm in advance of the Panel meeting.
    Procedures for Providing Public Comment: The SAB Staff Office 
accepts written public comments of any length, and will accommodate 
oral public comments whenever possible. The SAB Staff Office expects 
that public will not repeat previously-submitted oral or written 
statements. Oral Comments: Requests to provide oral comments must be in 
writing (e-mail, fax or mail) and received by Mr. Butterfield no later 
than October 20, 2005 to reserve time on the October 27, 2005 meeting 
agenda. Opportunities for oral comments will be limited to five minutes 
per speaker. Written Comments: Written comments should be received in 
the SAB Staff Office by October 21, 2005 so that the comments may be 
made available to the members of the members of the SAB AALM Review 
Panel for their consideration. Comments should be supplied to Mr. 
Butterfield at the contact information provided above, in the following 
formats: one hard copy with original signature, and one electronic copy 
via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, 
Word, or Rich Text files (in IBM-PC/Windows 98/2000/XP format)). Those 
providing written comments and who attend the meeting in person are 
also asked to bring 75 copies of their comments for public 
distribution.
    Meeting: Individuals requiring special accommodation at this 
meeting, including wheelchair access to the conference room, should 
contact Mr. Butterfield at the phone number or e-mail address noted 
above no later than October 20, 2005 so that appropriate arrangements 
can be made.


[[Page 60078]]


    Dated: October 6, 2005.
Anthony F. Maciorowski,
Associate Director for Science, EPA Science Advisory Board Staff 
Office.
[FR Doc. 05-20601 Filed 10-13-05; 8:45 am]
BILLING CODE 6560-50-P
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