Government-Owned Inventions; Availability for Licensing, 33910-33911 [05-11577]

Download as PDF 33910 Federal Register / Vol. 70, No. 111 / Friday, June 10, 2005 / Notices Licensing Contact: George Pipia; 301/ 435–5560; pipiag@mail.nih.gov. The invention provides a method for treating mammalian adenocarcinomas and sarcomas comprising administration of an effective amount of an inhibitor of HMG Co-A or homologues of the inhibitor. Adenocarcinoma is known to afflict the prostate, stomach, lung, breast and colon, as well as other sites. Examples of compounds useful in the present invention are lovastatin and simvastatin as well as their homologues. Also included are compounds classified as HMG Co-A inhibitors, as well as their homologues or analogues. Generally, these HMG Co-A inhibitors are known to lower serum cholesterol in humans. However, the present invention is not so limited. That is, an inhibitor of HMG Co-A or one of its homologues may work in the method of the present invention without necessarily lowering serum cholesterol. The invention focuses not on the compound’s ability to lower cholesterol, but rather on the compound’s ability to treat selected cancers, such as adenocarcinomas of the prostate, stomach, lung, breast and colon and certain sarcomas such as Ewing’s sarcoma. Also provided by the invention is a method of reducing prostate specific antigen (PSA) levels in a patient having prostatic adenocarcinoma comprising administration of an effective amount of a compound which is an inhibitor of HMG Co-A or a homologue of such inhibitor. The invention also includes a method of reducing PSA in conjunction with another treatment modality. The claims encompassing this technology are directed to the methods of treating certain types of cancer with inhibitors of HMG Co-A reductase, and specifically with lovastatin and simvastatin (see the U.S. issued patent 6,040,334: https://patft.uspto.gov/ netacgi/nphParser?Sect1=PTO1&Sect2= HITOFF&d=PALL&p=1&u=/netahtml/ srchnum.htm&r=1&f=G&l= 50&s1=6,040,334.WKU.&OS=PN/ 6,040,334&RS=PN/6,040,334). In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors. Dated: June 3, 2005. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. 05–11576 Filed 6–9–05; 8:45 am] BILLING CODE 4140–01–P VerDate jul<14>2003 17:22 Jun 09, 2005 Jkt 205001 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing National Institutes of Health, Public Health Service, DHHS. ACTION: Notice. AGENCY: SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: (301) 496–7057; fax: (301) 402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. Proteomic Profiles Associated With Aging Dr. Shari M. Ling (NIA). DHHS Reference No. E–354–2004/1— Research Tool. Licensing Contact: Marlene Shinn-Astor; 301/435–4426; shinnm@mail.nih.gov. This invention relates to proteomic profiles associated with normal aging. Biological markers (Biomarkers) that characterize the state of ‘‘normal aging’’ could provide a useful comparison for biomarkers of age-associated diseases (cardiovascular, cancer, arthritis). The profiles could then be used to develop markers linked with other diseases. The proteins identified could either be included in elisa or multiplex assays, or incorporated into a protein-based chip. These products would be of utility to characterize research subjects for clinical trials. Specific proteins or groups of proteins could be used as potential therapeutic targets to prevent or attenuate disease development or help to improve the normal aging process. In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors. PO 00000 Frm 00032 Fmt 4703 Sfmt 4703 AlphaB-Crystallin/HSPBE Gene Knockout Mouse Dr. Eric F. Wawrousek, et al. (NEI). DHHS Reference No. E–135–2001/0— Research Tool. Licensing Contact: Marlene Shinn-Astor; (301) 435–4426; shinnm@mail.nih.gov. The alpha crystallins and other members of the small heat shock family of proteins, have been shown to be very important proteins for preventing the irreversible destruction of other proteins. AlphaA is mostly restricted to the ocular lens, while alphaB is present in almost all cells of the body with the highest levels in ocular lens, heart, and skeletal muscle. The NIH has created lines of mice, which lack the alphaBcrystallin gene (and unintentionally, its neighboring gene HSPB2). These mouse lines could be used to study functions of these proteins in the eye, skeletal muscle, heart, and any other tissue or organ. In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors. Three Myelin Basic Protein-Specific T Cell Clones, TL2A6, TL5F6, and TL5G7 That Are Restricted by Multiple Sclerosis-Associated HLA–DR Molecules and Recognize the Immunodominant Myelin Basic Protein (MBP) Peptide MBP (83–99) Dr. Roland Martin, et al. (NINDS). DHHS Reference No. E–277–1999/0— Research Tool. Licensing Contact: Marlene Shinn-Astor; (301) 435–4426; shinnm@mail.nih.gov. Autoreactive T cell clones such as TL3A6 and TL5F6 that recognize an autoantigen, which is potentially relevant for an autoimmune disease, for example, multiple sclerosis (MS), offer the potential to examine the disease pathogenesis and develop new treatments. Such treatments aim at disrupting or interfering with the specific interaction between autoreactive T cells, antigen presenting cells and antigenic peptide. Current treatments have immunomodulatory effects and side effects. These T cell lines will be useful for developing novel treatment approaches for multiple sclerosis. The T cell lines can be used to test treatments that block or interfere with surface receptors of these cells. Mouse Model for Myasthenia Gravis Dr. Michael J. Lenardo et al. (NIAID). DHHS Reference No. E–188–1999/0— Research Tool. E:\FR\FM\10JNN1.SGM 10JNN1 Federal Register / Vol. 70, No. 111 / Friday, June 10, 2005 / Notices Licensing Contact: Marlene Shinn-Astor; (301) 435–4426; shinnm@mail.nih.gov. Myasthenia gravis is a disease that causes muscle weakness and paralysis due to an autoimmune process that attacks the muscle. So far no mouse model has been available which has limited investigation of the disease and the development of better treatments or a cure. Our inventors have created a transgenic mouse strain that manifests immunological reactivity that underlines myasthenia gravis. Use of Transgenic Mice To Assess the Systemic Effects of Tissue Inhibitor of Metalloproteinases-1 (TIMP) on Tumor Progression, Liver Fibrosis, Rheumatoid Arthritis, Wound Healing, and Angiogenesis Dr. Unnur P. Thorgeirsson, et al. (NCI). DHHS Reference No. E–273–1998/0— Research Tool. Licensing Contact: Marlene Shinn-Astor; (301) 435–4426; shinnm@mail.nih.gov. NIH researchers have produced transgenic mice over expressing human tissue inhibitor of metalloproteinases-1 (hTIMP) in the liver under the control of an albumin promoter. These mice produce large amounts of hTIMP–1 for extended periods of time, resulting in high levels of biologically active inhibitor released into the systemic circulation. In considering that the sustained high levels of circulating hTIMP–1 do not appear to affect the general health of these mice, this model can be used to study the protective effects of TIMP–1 on diseases, which involve extensive proteolytic matrix degradation and tissue remodeling. Examples of such diseases include malignant tumors, liver fibrosis, wound healing, rheumatoid arthritis, and a variety of angioproliferative diseases. Dated: June 3, 2005. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. 05–11577 Filed 6–9–05; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of a meeting of the VerDate jul<14>2003 17:22 Jun 09, 2005 Jkt 205001 Board of Scientific Counselors, National Cancer Institute. The meeting will be closed to the public as indicated below in accordance with the provisions set forth in section 552b(c)(6), Title 5 U.S.C., as amended for the review, discussion, and evaluation of individual intramural programs and projects conducted by the National Cancer Institute, including consideration of personnel qualifications and performance, and the competence of individual investigators, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Board of Scientific Counselors, National Cancer Institute, Subcommittee 1—Clinical Sciences and Epidemiology. Date: July 11–12, 2005 Time: July 11, 2005, 7 p.m. to 11 p.m. Agenda: To review and evaluate personal qualifications and performance, and competence of individual investigators. Place: Holiday Inn Select Bethesda, Versailles I, 8120 Wisconsin Avenue, Bethesda, MD 20814. Time: July 12, 2005, 9 a.m. 3:30 p.m. Agenda: To review and evaluate personal qualifications and performance, and competence of individual investigators. Place: National Institutes of Health, National Cancer Institute, 9000 Rockville Pike, Building 31, Conference Room 10, Bethesda, MD 20892. Contact Person: Brian E. Wojcik, PhD, Senior Review Administrator, Institute Review Office, Office of the Director, National Cancer Institute, 6116 Executive Boulevard, Room 2114, Bethesda, MD 20892, (301) 496–7628, wojcikb@mail.nih.gov. In the interest of security, NIH has instituted stringent procedures for entrance into the building by non-government employees. Persons without a government I.D. will need to show a photo I.D. and signin at the security desk upon entering the building. (Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control, National Institutes of Health, HHS.) Dated: June 6, 2005 LaVerne Y. Stringfield, Director, Office of Federal Advisory Committee Policy. [FR Doc. 05–11571 Filed 6–9–05; 8:45 am] BILLING CODE 4140–01–M PO 00000 Frm 00033 Fmt 4703 Sfmt 4703 33911 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. appendix 2), notice is hereby given of a meeting of the Board of Scientific Counselors, National Cancer Institute. The meeting will be closed to the public as indicated below in accordance with the provisions set forth in section 552b(c)(6), Title 5 U.S.C., as amended for the review, discussion, and evaluation of individual intramural programs and projects conducted by the National Cancer Institute, including consideration of personnel qualifications and performance, and the competence of individual investgators, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Board of Scientific Counselors, National Cancer Institute, Subcommittee 2—Basic Sciences. Date: July 11, 2005. Time: 10 a.m. to 3:30 p.m. Agenda: To review and evaluate personal qualifications and performance, and competence of individual invesstigators. Place: National Institutes of Health, National Cancer Institute, 9000 Rockville Pike, Building 31, Conference Room 6, Bethesda, MD 20892. Time: 7 p.m. to 11 p.m. Agenda: To review and evaluate personal qualifications and performance, and competence of individual investigators. Place: Holiday Inn Select Bethesda, Versailles I, 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Florence E. Farber, PhD, Health Scientific Administrator, Office of the Director, National Cancer Institute, National Institutes of Health, 6116 Executive Boulevard, Room 2115, Bethesda, MD 20892, (301) 496–7628, ff6p@nih.gov. In the interest of security, NIH has instituted stringent procedures for entrance into the building by non-government employees. Persons without a government I.D. will need to show a photo I.D. and signin at the security desk upon entering the building. (Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control, National Institutes of Health, HHS.) E:\FR\FM\10JNN1.SGM 10JNN1

Agencies

[Federal Register Volume 70, Number 111 (Friday, June 10, 2005)]
[Notices]
[Pages 33910-33911]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 05-11577]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, DHHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: (301) 496-7057; fax: (301) 402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Proteomic Profiles Associated With Aging

Dr. Shari M. Ling (NIA).
DHHS Reference No. E-354-2004/1--Research Tool.
Licensing Contact: Marlene Shinn-Astor; 301/435-4426; 
shinnm@mail.nih.gov.

    This invention relates to proteomic profiles associated with normal 
aging. Biological markers (Biomarkers) that characterize the state of 
``normal aging'' could provide a useful comparison for biomarkers of 
age-associated diseases (cardiovascular, cancer, arthritis). The 
profiles could then be used to develop markers linked with other 
diseases.
    The proteins identified could either be included in elisa or 
multiplex assays, or incorporated into a protein-based chip. These 
products would be of utility to characterize research subjects for 
clinical trials. Specific proteins or groups of proteins could be used 
as potential therapeutic targets to prevent or attenuate disease 
development or help to improve the normal aging process.
    In addition to licensing, the technology is available for further 
development through collaborative research opportunities with the 
inventors.

AlphaB-Crystallin/HSPBE Gene Knockout Mouse

Dr. Eric F. Wawrousek, et al. (NEI).
DHHS Reference No. E-135-2001/0--Research Tool.
Licensing Contact: Marlene Shinn-Astor; (301) 435-4426; 
shinnm@mail.nih.gov.

    The alpha crystallins and other members of the small heat shock 
family of proteins, have been shown to be very important proteins for 
preventing the irreversible destruction of other proteins. AlphaA is 
mostly restricted to the ocular lens, while alphaB is present in almost 
all cells of the body with the highest levels in ocular lens, heart, 
and skeletal muscle. The NIH has created lines of mice, which lack the 
alphaB-crystallin gene (and unintentionally, its neighboring gene 
HSPB2). These mouse lines could be used to study functions of these 
proteins in the eye, skeletal muscle, heart, and any other tissue or 
organ.
    In addition to licensing, the technology is available for further 
development through collaborative research opportunities with the 
inventors.

Three Myelin Basic Protein-Specific T Cell Clones, TL2A6, TL5F6, and 
TL5G7 That Are Restricted by Multiple Sclerosis-Associated HLA-DR 
Molecules and Recognize the Immunodominant Myelin Basic Protein (MBP) 
Peptide MBP (83-99)

Dr. Roland Martin, et al. (NINDS).
DHHS Reference No. E-277-1999/0--Research Tool.
Licensing Contact: Marlene Shinn-Astor; (301) 435-4426; 
shinnm@mail.nih.gov.

    Autoreactive T cell clones such as TL3A6 and TL5F6 that recognize 
an autoantigen, which is potentially relevant for an autoimmune 
disease, for example, multiple sclerosis (MS), offer the potential to 
examine the disease pathogenesis and develop new treatments. Such 
treatments aim at disrupting or interfering with the specific 
interaction between autoreactive T cells, antigen presenting cells and 
antigenic peptide. Current treatments have immunomodulatory effects and 
side effects. These T cell lines will be useful for developing novel 
treatment approaches for multiple sclerosis. The T cell lines can be 
used to test treatments that block or interfere with surface receptors 
of these cells.

Mouse Model for Myasthenia Gravis

Dr. Michael J. Lenardo et al. (NIAID).
DHHS Reference No. E-188-1999/0--Research Tool.

[[Page 33911]]

Licensing Contact: Marlene Shinn-Astor; (301) 435-4426; 
shinnm@mail.nih.gov.

    Myasthenia gravis is a disease that causes muscle weakness and 
paralysis due to an autoimmune process that attacks the muscle. So far 
no mouse model has been available which has limited investigation of 
the disease and the development of better treatments or a cure. Our 
inventors have created a transgenic mouse strain that manifests 
immunological reactivity that underlines myasthenia gravis.

Use of Transgenic Mice To Assess the Systemic Effects of Tissue 
Inhibitor of Metalloproteinases-1 (TIMP) on Tumor Progression, Liver 
Fibrosis, Rheumatoid Arthritis, Wound Healing, and Angiogenesis

Dr. Unnur P. Thorgeirsson, et al. (NCI).
DHHS Reference No. E-273-1998/0--Research Tool.
Licensing Contact: Marlene Shinn-Astor; (301) 435-4426; 
shinnm@mail.nih.gov.

    NIH researchers have produced transgenic mice over expressing human 
tissue inhibitor of metalloproteinases-1 (hTIMP) in the liver under the 
control of an albumin promoter. These mice produce large amounts of 
hTIMP-1 for extended periods of time, resulting in high levels of 
biologically active inhibitor released into the systemic circulation. 
In considering that the sustained high levels of circulating hTIMP-1 do 
not appear to affect the general health of these mice, this model can 
be used to study the protective effects of TIMP-1 on diseases, which 
involve extensive proteolytic matrix degradation and tissue remodeling. 
Examples of such diseases include malignant tumors, liver fibrosis, 
wound healing, rheumatoid arthritis, and a variety of 
angioproliferative diseases.

    Dated: June 3, 2005.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 05-11577 Filed 6-9-05; 8:45 am]
BILLING CODE 4140-01-P

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