Blackstone River Valley National Heritage Corridor Commission: Notice of Meeting, 18419 [05-7145]
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Federal Register / Vol. 70, No. 68 / Monday, April 11, 2005 / Notices
limitations imposed by the review and
funding cycle.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.306, Comparative Medicine;
93.333, Clinical Research, 93.306, 93.333,
93.337, 93.393–93.396, 93.837–93.844,
93.846–93.892, 93.893, National Institutes of
Health HHS)
Dated: April 4, 2005.
LaVerne Y. Stringfield,
Director, Office of Federal Advisory
Committee Policy
[FR Doc. 05–7245 Filed 4–8–05; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Prospective Grant of Exclusive
License: Methods for Using
Extracellular Adenosine Inhibitors and
Adenosine Receptor Inhibitors as
Applied to the Treatment of Human
Cancer and Tumors
National Institutes of Health,
Public Health Service, DHHS.
ACTION: Notice.
AGENCY:
SUMMARY: This is notice, in accordance
with 35 U.S.C. 209(c)(1) and 37 CFR
404.7(a)(1)(i), that the National
Institutes of Health (NIH), Department
of Health and Human Services, is
contemplating the grant of an exclusive
license to practice the invention
embodied in Patent Applications U.S.
60/340,772, filed on 12/12/2001, U.S.
60/342,582, filed on 12/19/2001, PCT/
US2002/036829, filed on 11/14/2002,
and corresponding EP, CA, AU, and JP
filings, as well as U.S. 10/498,416, filed
on 06/10/2004; entitled ‘‘Methods for
using extracellular adenosine inhibitors
and adenosine receptor inhibitors to
enhance immune response and
inflammation’’, all by Michail V.
Sitkovsky and Akio Ohta, to Adenosine
Therapeutics, LLC, having a place of
business in Charlottesville, VA. The
patent rights in this invention have been
assigned to the United States of
America.
DATES: Only written comments and/or
application for a license that are
received by the NIH Office of
Technology Transfer on or before June
10, 2005 will be considered.
ADDRESSES: Requests for a copy of the
patent application, inquiries, comments
and other materials relating to the
contemplated license should be directed
to: Cristina Thalhammer-Reyero, Ph.D.,
M.B.A., Office of Technology Transfer,
National Institutes of Health, 6011
Executive Boulevard, Suite 325,
VerDate jul<14>2003
17:45 Apr 08, 2005
Jkt 205001
Rockville, MD 20852–3804; E-mail:
ThalhamC@mail.nih.gov; Telephone:
301–435–4507; Facsimile: 301–402–
0220.
The
technology described and claimed in the
subject invention relates to methods to
enhance and prolong the body’s
immune response as well as to promote
targeted tissue damage, such as for
tumor destruction, by inhibiting
signaling through the adenosine
receptor. The inventors have shown that
adenosine A2a and A3a receptors play
a critical and non-redundant role in
down-regulation of inflammation in
vivo by acting as the physiological
termination mechanism that can limit
the immune response. The methods
described involve administering either
an adenosine-degrading drug or an
adenosine receptor antagonist to exert a
more effective and durable immune
response and inflammation, and more
specifically to the subject exclusive
license application, to reduce the size of
tumors. Furthermore, using the claimed
method in combination with
conventional anti tumor agent can be an
effective treatment against cancer.
The invention has potential
applications in the many markets in
which therapeutic and preventive uses
of manipulating the adenosine pathway
are involved, including the regulation of
hypoxia, tissue damage, tumor
destruction, inflammation, increasing
the efficacy of vaccines, and other
immune responses.
This invention is further described in
Ohta A et al., ‘‘Role of G-proteincoupled adenosine receptors in
downregulation of inflammation and
protection from tissue damage,’’ Nature
2001 Dec 20–27; 414(6866):916–20.
The prospective exclusive license will
be royalty bearing and will comply with
the terms and conditions of 35 U.S.C.
209 and 37 CFR 404.7. The prospective
exclusive license may be granted unless,
within 60 days from the date of this
published Notice, NIH receives written
evidence and argument that establishes
that the grant of the license would not
be consistent with the requirements of
35 U.S.C. 209 and 37 CFR 404.7.
The field of use may be limited to
‘‘Treatment of human cancer and
tumors’’.
Properly filed competing applications
for a license filed in response to this
notice will be treated as objections to
the contemplated license. Comments
and objections submitted in response to
this notice will not be made available
for public inspection, and, to the extent
permitted by law, will not be released
SUPPLEMENTARY INFORMATION:
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18419
under the Freedom of Information Act,
5 U.S.C. 552.
Dated: April 4, 2005.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 05–7248 Filed 4–8–05; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF INTERIOR
Office of the Secretary
Blackstone River Valley National
Heritage Corridor Commission: Notice
of Meeting
Notice is hereby given in accordance
with section 552b of title 5, United
States Code, that a meeting of the John
H. Chafee Blackstone River Valley
National Heritage Corridor Commission
will be held on Thursday, May 19, 2005.
The Commission was established
pursuant to Public Law 99–647. The
purpose of the Commission is to assist
Federal, State and local authorities in
the development and implementation of
an integrated resource management plan
for those lands and waters within the
Corridor.
The meeting will convene on May 19,
2005, at 7 p.m. at the Burrillville Town
Hall at 105 Harrisville Main Street,
Harrisville, RI 02830 for the following
reasons:
1. Approval of Minutes.
2. Chairman’s Report.
3. Executive Director’s Report.
4. Financial Budget.
5. Public Input.
It is anticipated that about twenty-five
people will be able to attend the session
in addition to the Commission
members.
Interested persons may make oral or
written presentations to the Commission
or file written statements. Such requests
should be made prior to the meeting to:
Larry Gall, Interim Executive Director,
John H. Chafee, Blackstone River Valley
National Heritage Corridor Commission,
One Depot Square, Woonsocket, RI
02895. Tel.: (401) 762–0250.
Further information concerning this
meeting may be obtained from Larry
Gall, Executive Director of the
Commission at the aforementioned
address.
Sue E. Andrews,
Chief of Interpretation, BRVNHCC.
[FR Doc. 05–7145 Filed 4–8–05; 8:45 am]
BILLING CODE 4310–RK–P
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[Federal Register Volume 70, Number 68 (Monday, April 11, 2005)]
[Notices]
[Page 18419]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 05-7145]
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DEPARTMENT OF INTERIOR
Office of the Secretary
Blackstone River Valley National Heritage Corridor Commission:
Notice of Meeting
Notice is hereby given in accordance with section 552b of title 5,
United States Code, that a meeting of the John H. Chafee Blackstone
River Valley National Heritage Corridor Commission will be held on
Thursday, May 19, 2005.
The Commission was established pursuant to Public Law 99-647. The
purpose of the Commission is to assist Federal, State and local
authorities in the development and implementation of an integrated
resource management plan for those lands and waters within the
Corridor.
The meeting will convene on May 19, 2005, at 7 p.m. at the
Burrillville Town Hall at 105 Harrisville Main Street, Harrisville, RI
02830 for the following reasons:
1. Approval of Minutes.
2. Chairman's Report.
3. Executive Director's Report.
4. Financial Budget.
5. Public Input.
It is anticipated that about twenty-five people will be able to
attend the session in addition to the Commission members.
Interested persons may make oral or written presentations to the
Commission or file written statements. Such requests should be made
prior to the meeting to: Larry Gall, Interim Executive Director, John
H. Chafee, Blackstone River Valley National Heritage Corridor
Commission, One Depot Square, Woonsocket, RI 02895. Tel.: (401) 762-
0250.
Further information concerning this meeting may be obtained from
Larry Gall, Executive Director of the Commission at the aforementioned
address.
Sue E. Andrews,
Chief of Interpretation, BRVNHCC.
[FR Doc. 05-7145 Filed 4-8-05; 8:45 am]
BILLING CODE 4310-RK-P
