National Toxicology Program (NTP); NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM); Ocular Toxicity Scientific Symposia: Mechanisms of Chemically-Induced Ocular Injury and Recovery and Minimizing Pain and Distress in Ocular Toxicity Testing, 18037-18038 [05-7002]

Download as PDF Federal Register / Vol. 70, No. 67 / Friday, April 8, 2005 / Notices 2. Elements of approval that the guidelines should include and justification of the elements; 3. Guidelines applying to all State governments; 4. Guidelines applying to all professional organizations; and 5. Inclusion of re-certification as an element of certification. Dated: March 31, 2005. Elizabeth M. Duke, Administrator. [FR Doc. 05–7017 Filed 4–7–05; 8:45 am] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Toxicology Program (NTP); NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM); Ocular Toxicity Scientific Symposia: Mechanisms of Chemically-Induced Ocular Injury and Recovery and Minimizing Pain and Distress in Ocular Toxicity Testing National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH). ACTION: Meeting announcement. AGENCY: SUMMARY: The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the NICEATM announce two upcoming scientific symposia entitled, ‘‘Mechanisms of Chemically-Induced Ocular Injury and Recovery’’ and ‘‘Minimizing Pain and Distress in Ocular Toxicity Testing.’’ DATES: The first symposium, ‘‘Mechanisms of Chemically-Induced Ocular Injury and Recovery,’’ will be held on May 11 and 12, 2005. The second symposium, ‘‘Minimizing Pain and Distress in Ocular Toxicity Testing,’’ will be held on May 13, 2005. In order to facilitate planning for this meeting, persons wishing to attend the symposia are asked to register via the ICCVAM/NICEATM Web site (https:// iccvam.niehs.nih.gov) by May 2, 2005. ADDRESSES: Both symposia will be held at the National Institutes of Health, Natcher Conference Center, 45 Center Drive, Bethesda, MD, 20892. An updated agenda and other information will be available on the NICEATM/ ICCVAM Web site (https:// iccvam.niehs.nih.gov) and can also be obtained from NICEATM (see FOR FURTHER INFORMATION CONTACT below). FOR FURTHER INFORMATION CONTACT: All correspondence should be submitted to the Director of NICEATM (Dr. William 19:00 Apr 07, 2005 Jkt 205001 SUPPLEMENTARY INFORMATION: Background BILLING CODE 4165–15–P VerDate jul<14>2003 S. Stokes, NICEATM, NIEHS, P.O. Box 12233, MD EC–17, Research Triangle Park, NC, 27709, (phone) 919–541– 2384, (fax) 919–541–0947, (e-mail) niceatm@niehs.nih.gov. Courier address: NICEATM, 79 T.W. Alexander Drive, Building 4401, Room 3128, Research Triangle Park, NC 27709. The symposium, ‘‘Mechanisms of Chemically-Induced Ocular Injury and Recovery,’’ will review the state-of-thescience and understanding of the pathophysiology and mechanisms of chemically-induced ocular injury and recovery (reversibility vs. irreversibility). The symposium will seek to identify research needed to address current knowledge gaps and that will advance the development and validation of test systems for regulatory testing that provide for protection of human health while reducing, refining (less pain and distress), and/or replacing the use of animals. The symposium, ‘‘Minimizing Pain and Distress in Ocular Toxicity Testing,’’ will review current understanding of the sources and mechanisms of pain and distress in ocular toxicity testing; identify current best practices for preventing, recognizing, and alleviating ocular pain and distress; and identify additional research, development, and validation studies necessary to support scientifically valid ocular testing procedures that avoid pain and distress. Preliminary Agenda Wednesday, May 11, 2005 8:30 a.m. • Welcome and Introduction of Symposium Objectives • Session 1—Overview of Recent Initiatives • Session 2—Current Ocular Injury and Toxicity Assessments • Session 3—Mechanisms and Biomarkers of Ocular Injury and Recovery • Discussion 5 p.m. PO 00000 Adjourn Day 1 Frm 00082 Fmt 4703 Sfmt 4703 Day 2 Thursday, May 12, 2005 8:30 a.m. • Session 4—In Vitro Models of Ocular Injury and Recovery • Discussion • Session 5—In Vivo Quantitative Objective Endpoints to Support Development and Validation of Predictive In Vitro Models • Discussion • Summary of Symposium Discussions 5 p.m. Adjourn Meeting Minimizing Pain and Distress in Ocular Toxicity Testing, May 13, 2005, National Institutes of Health, Natcher Conference Center, Balcony B, 45 Center Drive, Bethesda, MD 20892 (A photo ID is required to access the NIH campus). 8:30 a.m. • Welcome and Introduction of Symposium Objectives • Session 1—Recognition and Sources of Pain in Ocular Injuries and Safety Testing • Discussion: Clinical Signs, Lesions and Other Biomarkers of Pain and Distress in Animals • Session 2—Alleviation and Avoidance of Ocular Injury and Pain • Discussion • Session 3—Biomarkers that Can Serve as Earlier Humane Endpoints for Ocular Studies • Discussion • Closing Remarks 5 p.m. Mechanisms of Chemically-Induced Ocular Injury and Recovery, May 11 and 12, 2005, National Institutes of Health, Natcher Conference Center, Room E1/ E2, 45 Center Drive, Bethesda, MD 20892 (A photo ID is required to access the NIH campus). Day 1 18037 Adjourn Meeting Attendance and Registration The symposia will be held on May 11–13, 2005, from 8:30 a.m. until adjournment and are open to the public with attendance limited only by the space available. Individuals who plan to attend are strongly encouraged to register with NICEATM via the NICEATM/ICCVAM Web site (https:// iccvam.niehs.nih.gov) by May 2, 2005. A map of the NIH campus, including visitor parking, is available at https:// www.nih.gov/about/visitor/ index.htm#directions. Please note that a photo ID is required to access the NIH campus. Persons needing special assistance, such as sign language interpretation or other reasonable accommodation in order to attend, are asked to notify NICEATM at least 7 business days in advance of the meeting (see FOR FURTHER INFORMATION CONTACT above). E:\FR\FM\08APN1.SGM 08APN1 18038 Federal Register / Vol. 70, No. 67 / Friday, April 8, 2005 / Notices Availability of Meeting Materials An updated agenda and other additional information will be available on the ICCVAM Web site and upon request from NICEATM (see FOR FURTHER INFORMATION CONTACT above). Those persons who register by the deadline will be provided with materials for the meeting upon on-site check-in at the meeting. Background Information on ICCVAM and NICEATM ICCVAM is an interagency committee composed of representatives from 15 Federal regulatory and research agencies that use or generate toxicological information. ICCVAM conducts technical evaluations of new, revised, and alternative methods with regulatory applicability, and promotes the scientific validation and regulatory acceptance of toxicological test methods that more accurately assess the safety and hazards of chemicals and products while refining (less pain and distress), reducing, and replacing animal use. The ICCVAM Authorization Act of 2000 (Pub. L. 106–545, available at https:// iccvam.niehs.nih.gov/about/ PL106545.htm) establishes ICCVAM as a permanent interagency committee of the NIEHS under the NICEATM. NICEATM administers the ICCVAM and provides scientific and operational support for ICCVAM-related activities. NICEATM and ICCVAM work collaboratively to evaluate new, improved, and alternative test methods applicable to the needs of Federal agencies. Additional information about ICCVAM and NICEATM can be found at the following Web site: https://iccvam.niehs.nih.gov. Dated: March 31, 2005. Kenneth Olden, Director, National Toxicology Program. [FR Doc. 05–7002 Filed 4–7–05; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), title 5 U.S.C., as amended. The grant applications and the discussions could disclose VerDate jul<14>2003 19:00 Apr 07, 2005 Jkt 205001 confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Library of Medicine Special Emphasis Panel, R13’s Conference Grants. Date: May 4, 2005. Time: 1 p.m. to 2:30 p.m. Agenda: To review and evaluate grant applications. Place: National Library of Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817, (Telephone Conference Call). Contact Person: Hua-Chuan SIM, MD, Scientific Review Administrator, National Library of Medicine, Extramural Programs, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20892. (Catalogue of Federal Domestic Assistance Program Nos. 93.879, Medical Library Assistance, National Institutes of Health, HHS) Dated: March 31, 2005. LaVerne Y. Stringfield, Director, Office of Federal Advisory Committee Policy. [FR Doc. 05–7004 Filed 4–7–05; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Abuse of Painkillers. Date: April 11, 2005. Time: 10 a.m. to 11 a.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). PO 00000 Frm 00083 Fmt 4703 Sfmt 4703 Contact Person: Gayle M. Boyd, PhD, Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 3028–D MSC 7759, Bethesda, MD 20892, 301–451– 9956, gboyd@mail.nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special Emphasis Panel, ELSI Member Conflict SEP. Date: April 14, 2005. Time: 11 a.m. to 1 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 5636 Fishers Lane, Rockville, MD 20852, (Telephone Conference Call). Contact Person: Ken D. Nakamura, PhD, Scientific Review Administrator, Scientific Review Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, 301–402–0838. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special Emphasis Panel, ZRG1 BDCN–C 90 S: Genetics and Sleep Disorders. Date: April 19, 2005. Time: 1 p.m. to 2 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Jay Cinque, MS Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5186, MSC 7846, Bethesda, MD 20892, 301–435–1252, cinquej@csr.nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393–93.396, 93.837–93.844, 93.846–93.878, 93.892, 93.893, National Institutes of Health, HHS) Dated: March 31, 2005. LaVerne Y. Stringfield, Director, Office of Federal Advisory Committee Policy. [FR Doc. 05–7005 Filed 4–7–05; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Center for Scientific Review Special Emphasis Panel, March E:\FR\FM\08APN1.SGM 08APN1

Agencies

[Federal Register Volume 70, Number 67 (Friday, April 8, 2005)]
[Notices]
[Pages 18037-18038]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 05-7002]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES


National Toxicology Program (NTP); NTP Interagency Center for the 
Evaluation of Alternative Toxicological Methods (NICEATM); Ocular 
Toxicity Scientific Symposia: Mechanisms of Chemically-Induced Ocular 
Injury and Recovery and Minimizing Pain and Distress in Ocular Toxicity 
Testing

AGENCY: National Institute of Environmental Health Sciences (NIEHS), 
National Institutes of Health (NIH).

ACTION: Meeting announcement.

-----------------------------------------------------------------------

SUMMARY: The Interagency Coordinating Committee on the Validation of 
Alternative Methods (ICCVAM) and the NICEATM announce two upcoming 
scientific symposia entitled, ``Mechanisms of Chemically-Induced Ocular 
Injury and Recovery'' and ``Minimizing Pain and Distress in Ocular 
Toxicity Testing.''

DATES: The first symposium, ``Mechanisms of Chemically-Induced Ocular 
Injury and Recovery,'' will be held on May 11 and 12, 2005. The second 
symposium, ``Minimizing Pain and Distress in Ocular Toxicity Testing,'' 
will be held on May 13, 2005. In order to facilitate planning for this 
meeting, persons wishing to attend the symposia are asked to register 
via the ICCVAM/NICEATM Web site (https://iccvam.niehs.nih.gov) by May 2, 
2005.

ADDRESSES: Both symposia will be held at the National Institutes of 
Health, Natcher Conference Center, 45 Center Drive, Bethesda, MD, 
20892. An updated agenda and other information will be available on the 
NICEATM/ICCVAM Web site (https://iccvam.niehs.nih.gov) and can also be 
obtained from NICEATM (see FOR FURTHER INFORMATION CONTACT below).

FOR FURTHER INFORMATION CONTACT: All correspondence should be submitted 
to the Director of NICEATM (Dr. William S. Stokes, NICEATM, NIEHS, P.O. 
Box 12233, MD EC-17, Research Triangle Park, NC, 27709, (phone) 919-
541-2384, (fax) 919-541-0947, (e-mail) niceatm@niehs.nih.gov. Courier 
address: NICEATM, 79 T.W. Alexander Drive, Building 4401, Room 3128, 
Research Triangle Park, NC 27709.

SUPPLEMENTARY INFORMATION:

Background

    The symposium, ``Mechanisms of Chemically-Induced Ocular Injury and 
Recovery,'' will review the state-of-the-science and understanding of 
the pathophysiology and mechanisms of chemically-induced ocular injury 
and recovery (reversibility vs. irreversibility). The symposium will 
seek to identify research needed to address current knowledge gaps and 
that will advance the development and validation of test systems for 
regulatory testing that provide for protection of human health while 
reducing, refining (less pain and distress), and/or replacing the use 
of animals.
    The symposium, ``Minimizing Pain and Distress in Ocular Toxicity 
Testing,'' will review current understanding of the sources and 
mechanisms of pain and distress in ocular toxicity testing; identify 
current best practices for preventing, recognizing, and alleviating 
ocular pain and distress; and identify additional research, 
development, and validation studies necessary to support scientifically 
valid ocular testing procedures that avoid pain and distress.

Preliminary Agenda

    Mechanisms of Chemically-Induced Ocular Injury and Recovery, May 11 
and 12, 2005, National Institutes of Health, Natcher Conference Center, 
Room E1/E2, 45 Center Drive, Bethesda, MD 20892 (A photo ID is required 
to access the NIH campus).

Day 1 Wednesday, May 11, 2005

8:30 a.m.
     Welcome and Introduction of Symposium Objectives
     Session 1--Overview of Recent Initiatives
     Session 2--Current Ocular Injury and Toxicity Assessments
     Session 3--Mechanisms and Biomarkers of Ocular Injury and 
Recovery
     Discussion
5 p.m.
    Adjourn Day 1

Day 2 Thursday, May 12, 2005

8:30 a.m.
     Session 4--In Vitro Models of Ocular Injury and Recovery
     Discussion
     Session 5--In Vivo Quantitative Objective Endpoints to 
Support Development and Validation of Predictive In Vitro Models
     Discussion
     Summary of Symposium Discussions
5 p.m.
    Adjourn Meeting

    Minimizing Pain and Distress in Ocular Toxicity Testing, May 13, 
2005, National Institutes of Health, Natcher Conference Center, Balcony 
B, 45 Center Drive, Bethesda, MD 20892 (A photo ID is required to 
access the NIH campus).

8:30 a.m.
     Welcome and Introduction of Symposium Objectives
     Session 1--Recognition and Sources of Pain in Ocular 
Injuries and Safety Testing
     Discussion: Clinical Signs, Lesions and Other Biomarkers 
of Pain and Distress in Animals
     Session 2--Alleviation and Avoidance of Ocular Injury and 
Pain
     Discussion
     Session 3--Biomarkers that Can Serve as Earlier Humane 
Endpoints for Ocular Studies
     Discussion
     Closing Remarks
5 p.m.
    Adjourn Meeting

Attendance and Registration

    The symposia will be held on May 11-13, 2005, from 8:30 a.m. until 
adjournment and are open to the public with attendance limited only by 
the space available. Individuals who plan to attend are strongly 
encouraged to register with NICEATM via the NICEATM/ICCVAM Web site 
(https://iccvam.niehs.nih.gov) by May 2, 2005. A map of the NIH campus, 
including visitor parking, is available at https://www.nih.gov/about/
visitor/index.htm#directions. Please note that a photo ID is required 
to access the NIH campus. Persons needing special assistance, such as 
sign language interpretation or other reasonable accommodation in order 
to attend, are asked to notify NICEATM at least 7 business days in 
advance of the meeting (see FOR FURTHER INFORMATION CONTACT above).

[[Page 18038]]

Availability of Meeting Materials

    An updated agenda and other additional information will be 
available on the ICCVAM Web site and upon request from NICEATM (see FOR 
FURTHER INFORMATION CONTACT above). Those persons who register by the 
deadline will be provided with materials for the meeting upon on-site 
check-in at the meeting.

Background Information on ICCVAM and NICEATM

    ICCVAM is an interagency committee composed of representatives from 
15 Federal regulatory and research agencies that use or generate 
toxicological information. ICCVAM conducts technical evaluations of 
new, revised, and alternative methods with regulatory applicability, 
and promotes the scientific validation and regulatory acceptance of 
toxicological test methods that more accurately assess the safety and 
hazards of chemicals and products while refining (less pain and 
distress), reducing, and replacing animal use. The ICCVAM Authorization 
Act of 2000 (Pub. L. 106-545, available at https://iccvam.niehs.nih.gov/
about/PL106545.htm) establishes ICCVAM as a permanent interagency 
committee of the NIEHS under the NICEATM. NICEATM administers the 
ICCVAM and provides scientific and operational support for ICCVAM-
related activities. NICEATM and ICCVAM work collaboratively to evaluate 
new, improved, and alternative test methods applicable to the needs of 
Federal agencies. Additional information about ICCVAM and NICEATM can 
be found at the following Web site: https://iccvam.niehs.nih.gov.

    Dated: March 31, 2005.
Kenneth Olden,
Director, National Toxicology Program.
[FR Doc. 05-7002 Filed 4-7-05; 8:45 am]
BILLING CODE 4140-01-P
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