Fifty-Fifth Report of the TSCA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for Comments, 7364-7377 [05-2714]
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7364
Federal Register / Vol. 70, No. 28 / Friday, February 11, 2005 / Notices
ENVIRONMENTAL PROTECTION
AGENCY
[OPPT–2004–0130; FRL–7692–1]
Fifty-Fifth Report of the TSCA
Interagency Testing Committee to the
Administrator of the Environmental
Protection Agency; Receipt of Report
and Request for Comments
Environmental Protection
Agency (EPA).
ACTION: Notice.
AGENCY:
SUMMARY: The Toxic Substances Control
Act (TSCA) Interagency Testing
Committee (ITC) transmitted its FiftyFifth Report to the Administrator of EPA
on December 8, 2004. In the 55th ITC
Report, which is included with this
notice, the ITC is revising the Priority
Testing List by adding a category of high
production volume (HPV) orphan
chemicals and requesting that EPA add
these chemicals to the TSCA section
8(a) Preliminary Assessment
Information Reporting (PAIR) rule and
the TSCA section 8(d) Health and Safety
Data Reporting (HaSDR) rule. The ITC is
also removing the following chemicals
from the Priority Testing List: 3-amino5-mercapto-1,2,4-triazole; glycoluril;
benzenamine, 3-chloro-2,6-dinitro-N,Ndipropyl-4-(trifluoromethyl)-; stannane,
dimethylbis[(1-oxoneodecyl)oxy]-;
benzene, 1,3,5-tribromo-2-(2propenyloxy)-; and1-triazene, 1,3diphenyl-.]. Since the 55th Report was
ITC transmitted to the Administrator
and made publicly available on https://
www.epa.gov/opptintr/itc/, five HPV
orphan chemicals have been removed
from the Priority Testing List because
chemical manufacturers committed to
prepare robust summaries for these
chemicals in response to the HPV
Challenge Program. The ITC encourages
other manufacturers to make similar
commitments so their chemicals can be
removed from the Priority Testing List
and potentially avoid being added to
PAIR and HaSDR rules.
DATES: Comments, identified by docket
identification (ID) number OPPT–2004–
0130, must be received on or before
March 14, 2005.
ADDRESSES: Comments may be
submitted electronically, by mail, or
through hand delivery/courier. Follow
the detailed instructions as provided in
Unit I. of the SUPPLEMENTARY
INFORMATION.
FOR FURTHER INFORMATION CONTACT: For
general information contact:
Colby Lintner, Regulatory
Coordinator, Environmental Assistance
Division (7408M), Office of Pollution
Prevention and Toxics, Environmental
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Protection Agency, 1200 Pennsylvania
Ave., NW., Washington, DC 20460–
0001; telephone number: (202) 554–
1404; e-mail address: TSCAHotline@epa.gov.
For technical information contact:
John D. Walker, Director, TSCA
Interagency Testing Committee (7401),
Office of Pollution Prevention and
Toxics, Environmental Protection
Agency, 1200 Pennsylvania Ave., NW.,
Washington, DC 20460–0001; e-mail
address: walker.johnd@epa.gov.
SUPPLEMENTARY INFORMATION:
I. General Information
A. Does this Action Apply to Me?
This notice is directed to the public
in general. It may, however, be of
particular interest to you if you
manufacture (defined by statute to
include import) and/or process TSCAcovered chemicals and you may be
identified by the North American
Industrial Classification System
(NAICS) codes 325 and 32411. Because
this notice is directed to the general
public and other entities may also be
interested, the Agency has not
attempted to describe all the specific
entities that may be interested in this
action. If you have any questions
regarding the applicability of this action
to a particular entity, consult the
technical person listed under FOR
FURTHER INFORMATION CONTACT.
B. How Can I Get Copies of this
Document and Other Related
Information?
1. Docket. EPA has established an
official public docket for this action
under docket ID number OPPT–2004–
0130. The official public docket consists
of the documents specifically referenced
in this action, any public comments
received, and other information related
to this action. Although a part of the
official docket, the public docket does
not include Confidential Business
Information (CBI) or other information
whose disclosure is restricted by statute.
The official public docket is the
collection of materials that is available
for public viewing at the EPA Docket
Center, Rm. B102-Reading Room, EPA
West, 1301 Constitution Ave., NW.,
Washington, DC. The EPA Docket
Center is open from 8:30 a.m. to 4:30
p.m., Monday through Friday, excluding
legal holidays. The EPA Docket Center
Reading Room telephone number is
(202) 566–1744 and the telephone
number for the OPPT Docket, which is
located in EPA Docket Center, is (202)
566–0280.
2. Electronic access. You may access
this Federal Register document
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electronically through the EPA Internet
under the ‘‘Federal Register’’ listings at
https://www.epa.gov/fedrgstr/. You may
also access additional information about
the ITC at https://www.epa.gov/opptintr/
itc/ or through the web site for the
Office of Prevention, Pesticides and
Toxic Substances (OPPTS) at https://
www.epa.gov/opptsfrs/home/
opptsim.htm/.
An electronic version of the public
docket is available through EPA’s
electronic public docket and comment
system, EPA Dockets. You may use EPA
Dockets at https://www.epa.gov/edocket/
to submit or view public comments,
access the index listing of the contents
of the official public docket, and to
access those documents in the public
docket that are available electronically.
Although not all docket materials may
be available electronically, you may still
access any of the publicly available
docket materials through the docket
facility identified in Unit I.B.1. Once in
the system, select ‘‘search,’’ then key in
the appropriate docket ID number.
Certain types of information will not
be placed in the EPA Dockets.
Information claimed as CBI and other
information whose disclosure is
restricted by statute, which is not
included in the official public docket,
will not be available for public viewing
in EPA’s electronic public docket. EPA’s
policy is that copyrighted material will
not be placed in EPA’s electronic public
docket but will be available only in
printed, paper form in the official public
docket. To the extent feasible, publicly
available docket materials will be made
available in EPA’s electronic public
docket. When a document is selected
from the index list in EPA Dockets, the
system will identify whether the
document is available for viewing in
EPA’s electronic public docket.
Although not all docket materials may
be available electronically, you may still
access any of the publicly available
docket materials through the docket
facility identified in Unit I.B.1. EPA
intends to work towards providing
electronic access to all of the publicly
available docket materials through
EPA’s electronic public docket.
For public commenters, it is
important to note that EPA’s policy is
that public comments, whether
submitted electronically or in paper,
will be made available for public
viewing in EPA’s electronic public
docket as EPA receives them and
without change, unless the comment
contains copyrighted material, CBI, or
other information whose disclosure is
restricted by statute. When EPA
identifies a comment containing
copyrighted material, EPA will provide
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a reference to that material in the
version of the comment that is placed in
EPA’s electronic public docket. The
entire printed comment, including the
copyrighted material, will be available
in the public docket.
Public comments submitted on
computer disks that are mailed or
delivered to the docket will be
transferred to EPA’s electronic public
docket. Public comments that are
mailed or delivered to the docket will be
scanned and placed in EPA’s electronic
public docket. Where practical, physical
objects will be photographed, and the
photograph will be placed in EPA’s
electronic public docket along with a
brief description written by the docket
staff.
C. How and to Whom Do I Submit
Comments?
You may submit comments
electronically, by mail, or through hand
delivery/courier. To ensure proper
receipt by EPA, identify the appropriate
docket ID number in the subject line on
the first page of your comment. Please
ensure that your comments are
submitted within the specified comment
period. Comments received after the
close of the comment period will be
marked ‘‘late.’’ EPA is not required to
consider these late comments. If you
wish to submit CBI or information that
is otherwise protected by statute, please
follow the instructions in Unit I.D. Do
not use EPA Dockets or e-mail to submit
CBI or information protected by statute.
1. Electronically. If you submit an
electronic comment as prescribed in this
unit, EPA recommends that you include
your name, mailing address, and an email address or other contact
information in the body of your
comment. Also include this contact
information on the outside of any disk
or CD ROM you submit, and in any
cover letter accompanying the disk or
CD ROM. This ensures that you can be
identified as the submitter of the
comment and allows EPA to contact you
in case EPA cannot read your comment
due to technical difficulties or needs
further information on the substance of
your comment. EPA’s policy is that EPA
will not edit your comment, and any
identifying or contact information
provided in the body of a comment will
be included as part of the comment that
is placed in the official public docket,
and made available in EPA’s electronic
public docket. If EPA cannot read your
comment due to technical difficulties
and cannot contact you for clarification,
EPA may not be able to consider your
comment.
i. EPA Dockets. Your use of EPA’s
electronic public docket to submit
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comments to EPA electronically is
EPA’s preferred method for receiving
comments. Go directly to EPA Dockets
at https://www.epa.gov/edocket/, and
follow the online instructions for
submitting comments. Once in the
system, select ‘‘search,’’ and then key in
docket ID number OPPT–2004–0130.
The system is an ‘‘anonymous access’’
system, which means EPA will not
know your identity, e-mail address, or
other contact information unless you
provide it in the body of your comment.
ii. E-mail. Comments may be sent by
e-mail to oppt.ncic@epa.gov, Attention:
Docket ID Number OPPT–2004–0130. In
contrast to EPA’s electronic public
docket, EPA’s e-mail system is not an
‘‘anonymous access’’ system. If you
send an e-mail comment directly to the
docket without going through EPA’s
electronic public docket, EPA’s e-mail
system automatically captures your email address. E-mail addresses that are
automatically captured by EPA’s e-mail
system are included as part of the
comment that is placed in the official
public docket, and made available in
EPA’s electronic public docket.
iii. Disk or CD ROM. You may submit
comments on a disk or CD ROM that
you mail to the mailing address
identified in Unit I.C.2. These electronic
submissions will be accepted in
WordPerfect or ASCII file format. Avoid
the use of special characters and any
form of encryption.
2. By mail. Send your comments to:
Document Control Office (7407M),
Office of Pollution Prevention and
Toxics (OPPT), Environmental
Protection Agency, 1200 Pennsylvania
Ave., NW., Washington, DC 20460–
0001.
3. By hand delivery or courier. Deliver
your comments to: OPPT Document
Control Office (DCO), EPA East Bldg.,
Rm. 6428, 1201 Constitution Ave., NW.,
Washington, DC. Attention: Docket ID
Number OPPT–2004–0130. The DCO is
open from 8 a.m. to 4 p.m., Monday
through Friday, excluding legal
holidays. The telephone number for the
DCO is (202) 564–8930.
D. How Should I Submit CBI to the
Agency?
Do not submit information that you
consider to be CBI electronically
through EPA’s electronic public docket
or by e-mail. You may claim
information that you submit to EPA as
CBI by marking any part or all of that
information as CBI (if you submit CBI
on disk or CD ROM, mark the outside
of the disk or CD ROM as CBI and then
identify electronically within the disk or
CD ROM the specific information that is
CBI). Information so marked will not be
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disclosed except in accordance with
procedures set forth in 40 CFR part 2.
In addition to one complete version of
the comment that includes any
information claimed as CBI, a copy of
the comment that does not contain the
information claimed as CBI must be
submitted for inclusion in the public
docket and EPA’s electronic public
docket. If you submit the copy that does
not contain CBI on disk or CD ROM,
mark the outside of the disk or CD ROM
clearly that it does not contain CBI.
Information not marked as CBI will be
included in the public docket and EPA’s
electronic public docket without prior
notice. If you have any questions about
CBI or the procedures for claiming CBI,
please consult the technical person
listed under FOR FURTHER INFORMATION
CONTACT.
E. What Should I Consider as I Prepare
My Comments for EPA?
We invite you to provide your views
and comments on the ITC’s 55th Report.
You may find the following suggestions
helpful for preparing your comments:
1. Explain your views as clearly as
possible.
2. Describe any assumptions that you
used.
3. Provide copies of any technical
information and/or data you used that
support your views.
4. Provide specific examples to
illustrate your concerns.
5. Make sure to submit your
comments by the deadline in this
notice.
6. To ensure proper receipt by EPA,
be sure to identify the docket ID number
assigned to this action in the subject
line on the first page of your response.
You may also provide the name, date,
and Federal Register citation.
II. Background
The Toxic Substances Control Act
(TSCA) (15 U.S.C. 260l et seq.)
authorizes the Administrator of the EPA
to promulgate regulations under section
4(a) of TSCA requiring testing of
chemicals and chemical groups in order
to develop data relevant to determining
the risks that such chemicals and
chemical groups may present to health
or the environment. Section 4(e) of
TSCA established the ITC to
recommend chemicals and chemical
groups to the Administrator of the EPA
for priority testing consideration.
Section 4(e) of TSCA directs the ITC to
revise the TSCA section 4(e) Priority
Testing List at least every 6 months.
A. The ITC’s 55th Report
The 55th ITC Report was transmitted
to EPA’s Administrator on December 8,
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2004, and is included in this notice. In
the 55th ITC Report, the ITC is revising
the Priority Testing List by adding a
category of HPV orphan chemicals and
requesting that EPA add these chemicals
to the TSCA section 8(a) PAIR rule and
the TSCA section 8(d) HaSDR rule. The
ITC is also removing the following
chemicals from the Priority Testing List:
3-amino-5-mercapto-1,2,4-triazole;
glycoluril; benzenamine, 3-chloro-2,6dinitro-N,N-dipropyl-4(trifluoromethyl)-; stannane,
dimethylbis[(1-oxoneodecyl)oxy]-;
benzene, 1,3,5-tribromo-2-(2propenyloxy)-; and 1-triazene, 1,3diphenyl-.
B. Status of the Priority Testing List
The current TSCA 4(e) Priority
Testing List as of December 2004 can be
found in Table 1 of the 55th ITC Report,
which is included in this notice.
List of Subjects
Environmental protection, Chemicals,
Hazardous substances.
Dated: February 3, 2005.
Charles M. Auer,
Director, Office of Pollution Prevention and
Toxics.
Fifty-Fifth Report of the TSCA
Interagency Testing Committee to the
Administrator, U.S. Environmental
Protection Agency
2. Glycoluril.
3. Benzenamine, 3-chloro-2,6-dinitro-N,Ndipropyl-4-(trifluoromethyl)-.
4. Stannane, dimethylbis[(1oxoneodecyl)oxy]-.
5. Benzene, 1,3,5-tribromo-2-(2propenyloxy)-.
6. 1-Triazene, 1,3-diphenyl-.
V. References
VI. The TSCA Interagency Testing Committee
Table of Contents
Summary
Summary
I. Background
II. TSCA Section 8 Reporting
A. TSCA Ssection 8 Reporting Rules
B. ITC’s Use of TSCA Section 8 and Other
Information
C. Previous Requests to Add Chemicals to the
TSCA Section 8(a) PAIR Rule
D. New Requests to Add Chemicals to the
TSCA Section 8(a) PAIR and 8(d) HaSDR
Rules
III. ITC’s Activities During this Reporting
Period (May to November 2004)
IV. Revisions to the TSCA Section 4(e)
Priority Testing List
A. Chemicals Added to the Priority Testing
List: HPV Orphan Chemicals
B. Chemicals Removed From the Priority
Testing List
1. 3-Amino-5-mercapto-1,2,4-triazole.
In this 55th ITC Report, the ITC is revising
the Priority Testing List by adding a category
of High Production Volume (HPV) orphan
chemicals and requesting that EPA add these
chemicals to the Toxic Substances Control
Act (TSCA) section 8(a) Preliminary
Assessment Information Reporting (PAIR)
rule and the TSCA section 8(d) Health and
Safety Data Reporting (HaSDR) rule. The ITC
is also removing the following chemicals
from the Priority Testing List: 3-amino-5mercapto-1,2,4-triazole; glycoluril;
benzenamine, 3-chloro-2,6-dinitro-N,Ndipropyl-4-(trifluoromethyl)-; stannane,
dimethylbis[(1-oxoneodecyl)oxy]-; benzene,
1,3,5-tribromo-2-(2-propenyloxy)-; and 1triazene, 1,3-diphenyl-.
The TSCA section 4(e) Priority Testing List
is Table 1 of this unit.
TABLE 1.—THE TSCA SECTION 4(E) PRIORITY TESTING LIST (NOVEMBER 2004)
ITC Report
Date
Chemical name/group
Action
31
January 1993
13 Chemicals with insufficient dermal absorption rate data
Designated
32
May 1993
16 Chemicals with insufficient dermal absorption rate data
Designated
35
November 1994
4 Chemicals with insufficient dermal absorption rate data
Designated
37
November 1995
4-Tert-butylphenol and Branched nonylphenol (mixed isomers)
Recommended
41
November 1997
Phenol, 4-(1,1,3,3-tetramethylbutyl)-
Recommended
47
November 2000
9 Indium compounds
Recommended
51
November 2002
18 Vanadium compounds
Recommended
53
November 2003
3 Pyridinamines
Recommended
53
November 2003
20 Tungsten compounds
Recommended
55
November 2004
HPV orphan chemicals
Recommended
I. Background
The ITC was established by section 4(e) of
TSCA ‘‘to make recommendations to the
Administrator respecting the chemical
substances and mixtures to which the
Administrator should give priority
consideration for the promulgation of rules
for testing under section 4(a).... At least every
six months ..., the Committee shall make
such revisions to the Priority Testing List as
it determines to be necessary and transmit
them to the Administrator together with the
Committee’s reasons for the revisions’’
(Public Law 94–469, 90 Stat. 2003 et seq., 15
U.S.C. 2601 et seq.). ITC Reports are available
from the ITC’s web site (https://www.epa.gov/
opptintr/itc/) within a few days of
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submission to the Administrator and from
the EPA’s web site https://www.epa.gov/
fedrgstr/ after publication in the Federal
Register. The ITC produces its revisions to
the Priority Testing List with administrative
and technical support from the ITC Staff and
ITC Members and their U.S. Government
organizations, and contract support provided
by EPA. ITC Members and Staff are listed at
the end of this report.
II. TSCA Section 8 Reporting
A. TSCA Section 8 Reporting Rules
Following receipt of the ITC’s Report (and
the revised Priority Testing List) by the EPA
Administrator, the EPA’s Office of Pollution
Prevention and Toxics (OPPT) may add the
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chemicals from the revised Priority Testing
List to the TSCA section 8(a) Preliminary
Assessment Information Reporting (PAIR)
and TSCA section 8(d) Health and Safety
Data Reporting (HaSDR) rules. The PAIR rule
requires producers and importers of
chemicals added to the Priority Testing List
to submit production and exposure reports
(https://www.epa.gov/opptintr/chemtest/
pairform.pdf/). The HaSDR rule requires
producers, importers and processors of all
chemicals added to the Priority Testing List
to submit unpublished health and safety
studies under TSCA section 8(d) that must be
in compliance with the revised HaSDR rule
(Ref. 1). All submissions must be received by
the EPA within 90 days of the reporting rules
Federal Register publication date.
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B. ITC’s Use of TSCA Section 8 and Other
Information
The ITC’s use of TSCA section 8 and other
information is described in previous ITC
Reports (https://www.epa.gov/opptintr/itc/
rptmain.htm/).
C. Previous Requests to Add Chemicals to the
TSCA Section 8(a) PAIR Rule
In its 53rd Report, the ITC requested that
EPA add 3 pyridinamines and 20 tungsten
compounds to the TSCA section 8(a) PAIR
rule (Ref. 2). On December 7, 2004, EPA
issued a final rule, pursuant to TSCA section
8(a) requiring producers and importers of
these 23 chemicals to report production,
importation, and exposure data to EPA (Ref.
3).
D. New Requests to Add Chemicals to the
TSCA Section 8(a) PAIR and 8(d) HaSDR
Rules
In this report, the ITC is requesting that
EPA add the HPV orphan chemicals listed in
Appendix A to the TSCA section 8(a) PAIR
and 8(d) HaSDR rules. The ITC is requesting
that these HPV orphan chemicals be added
to the TSCA section 8(a) PAIR and 8(d)
HaSDR rules because no voluntary studies
have been submitted to the EPA in response
to the HPV Challenge Program (https://
www.epa.gov/opptintr/chemrtk/volchall.htm/
).
III. ITC’s Activities During this Reporting
Period (May to November 2004)
During this reporting period, the ITC
reviewed the reports submitted in response
to the June 11, 2003, PAIR rule (Ref. 4) and
the May 4, 2004, TSCA section 8(d) HaSDR
rule (Ref. 5). The ITC is continuing to review
these reports.
The ITC also met with EPA to discuss
procedures for making data publicly
available on HPV orphan chemicals (HPV
chemicals for which no sponsors have
volunteered to develop and submit robust
summaries to the EPA). The ITC’s
discussions with EPA are described in
section IV. of this report.
As noted in the 51st and 54th ITC Reports
(Refs. 6 and 7), the ITC continues to request
the following information on vanadium
compounds:
1. Recent non-CBI estimates of annual
production or importation volume data and
trends, and use information, including
percentages of production or importation that
are associated with different uses.
2. Estimates of the number of humans and
concentrations of vanadium chemicals to
which humans may be exposed in each
relevant manufacturing or processing
scenario.
3. Health effects data including
pharmacokinetics, genotoxicity, subchronic
toxicity, reproductive and developmental
toxicity, and any human data from
occupationally exposed workers.
The ITC seeks this information in order to
adequately assess the extent and degree of
exposure and potential hazard associated
with the various forms of vanadium.
In addition, the ITC is concerned that some
of these compounds may be released into fly
ash ponds at power plants, petroleum and
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chemical refineries, and mining sites and
could be toxic to avian and wildlife species
as exemplified by a recent report of dead and
dying Canada geese at a petroleum refinery
fly ash pond in Delaware. In these geese, the
vanadium concentrations in pooled liver and
kidney samples were 57 and 226 µg/gram (g)
dry weight, respectively. Background
concentrations of vanadium in various
tissues of higher vertebrates, including
waterfowl, rarely exceed 1 µg/g dry weight.
Limited data are available on vanadium
toxicity in birds and other wildlife making it
difficult to interpret the findings from the
geese die-off.
The ITC knows that vanadium is released
into impoundments at 172 facilities in 33
states and that the TRI does not have
vanadium concentrations for these
impoundments. The ITC is soliciting data on
concentrations and species of vanadium
compounds in impoundments at power
plants, petroleum and chemical refineries,
and mining sites and information on the use,
release, and presence of vanadium
compounds at these facilities. The ITC needs
these data and information to determine if
avian wildlife in the vicinity of the 172
facilities are at risk from exposure to
vanadium compounds. If you have any
questions regarding the applicability of this
action to a particular entity, consult the
technical person listed under FOR FURTHER
INFORMATION CONTACT.
IV. Revisions to the TSCA Section 4(e)
Priority Testing List
A. Chemicals Added to the Priority Testing
List: HPV Orphan Chemicals
1. Recommendation. EPA requests that the
ITC add the category HPV orphan chemicals
listed in Appendix A of this report to the
Priority Testing List to obtain importation,
production, use, and exposure information as
well as unpublished physical/chemical
property, environmental fate, health effects,
and ecological effects information to meet
U.S. Government data needs.
2. Rationale for recommendation. While
the success of the HPV Challenge Program
has been significant, hundreds of chemicals
that were eligible for sponsorship in the
Program continue to remain unsponsored.
These chemicals are referred to as ‘‘orphans.’’
There is little or no publicly available
information regarding the potential hazards
associated with these chemicals. EPA
remains committed to obtain basic screening
level hazard information on these chemicals
through voluntary sponsorship, as well as
through TSCA information gathering and test
rules, as necessary.
3. Supporting information. In developing
the list of HPV orphan chemicals presented
in Appendix A of this report, EPA considered
all of the HPV orphan chemicals and then
removed selected HPV orphan chemicals.
The HPV orphan chemicals presented in
Appendix A of this report do not include
those HPV orphan chemicals that:
a. Had 2002 Inventory Update rule
reported production/importation volumes >
one million pounds (https://www.epa.gov/
oppt/iur/iur02/index.htm/ ) and were
proposed for testing in the first HPV test rule
(Ref. 8).
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b. Meet the ‘‘No Longer HPV’’ criteria (i.e.,
chemicals with production/importation
volumes < 1 million pounds based on 1998
and 2002 Inventory Update Rule data (http:/
/www.epa.gov/oppt/iur/iur02/index.htm/)).
c. Are being considered for a second HPV
TSCA section 4 test rule because they may
meet the TSCA section 4(a)(1)(B) statutory
requirements.
At EPA’s request, the ITC encourages
manufacturers of these chemicals to visit the
EPA’s HPV Challenge Program web site
(https://www.epa.gov/opptintr/chemrtk/
volchall.htm/) and to make a commitment to
sponsor these chemicals at the present time,
before regulatory actions are initiated. EPA
will initiate development of TSCA section
8(a) PAIR and 8(d) HaSDR rules soon after
these chemicals are added to the Priority
Testing List and the ITC’s 55th Report is
published in the Federal Register. Also at
EPA’s request, the ITC encourages the
submission of robust summaries of studies
submitted under the TSCA section 8(d)
HaSDR rule to facilitate EPA’s review of the
unpublished TSCA section 8(d) studies (see
USEPA. 1999. Draft Guidance on Developing
Robust Summaries. October 22, 1999 (http:/
/www.epa.gov/chemrtk/robsumgd.htm/)).
While some of the HPV orphan chemicals
have been previously added to the TSCA
section 8(d) HaSDR rule, all of the sunset
dates for these chemicals have expired (see
Appendix A of this report), thus new and so
far unreported studies would need to be
submitted. Information about the
environmental fate and potential hazards
associated with these chemicals when
combined with information about exposure
and uses will allow the EPA and others to
evaluate and prioritize potential health and
environmental effects and determine the
need for test rules under TSCA section 4(a).
If you have any questions regarding the
applicability of this action to a particular
entity, consult the technical person listed
under FOR FURTHER INFORMATION CONTACT.
4. Information needs. For each individual
substance listed in Appendix A of this report,
EPA needs the following information to
assess the extent and degree of exposure and
potential hazard associated with these
substances:
a. Production, importation, processing, use
and associated exposure information that is
captured under the TSCA section 8(a) PAIR
form.
b. Unpublished studies of:
i. Physical/chemical properties and
environmental fate for the properties listed in
40 CFR 716.50 as well as melting point and
boiling point.
ii. Health effects including
pharmacokinetics, genotoxicity, acute
toxicity, subacute toxicity, subchronic
toxicity, chronic toxicity, reproductive
toxicity, developmental toxicity,
immunotoxicity, neurotoxicity, and
oncogenicity/carcinogenicity.
iii. Ecological effects including acute and
chronic toxicity studies of aquatic and
terrestrial vertebrates and invertebrates and
aquatic plants.
c. Only studies where the recommended
HPV orphan chemical is ≥ 90% of the test
substance by weight should be submitted. In
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addition, only studies that were conducted
using TSCA, Federal Insecticide, Fungicide,
and Rodenticide Act (FIFRA), Organization
for Economic Cooperation and Development
(OECD), or other internationally accepted test
guidelines or voluntary consensus standards
should be submitted. Studies performed
where the recommended HPV orphan
chemical is < 90% of the test substance by
weight are not requested at this time.
B. Chemicals Removed From the Priority
Testing List
1. 3-Amino-5-mercapto-1,2,4-triazole. 3Amino-5-mercapto-1,2,4-triazole (Chemical
Abstracts Service Registry Number (CAS No.)
16691–43–3 ) was added to the Priority
Testing List in the ITC’s 42nd Report to obtain
annual production/importation volumes and
trends, use, exposure, and health effects data
(Ref. 9). The addition was based on concerns
that 3-amino-5-mercapto-1,2,4-triazole was
structurally related to 3-amino-1,2,4-triazole
(Amitrol), a herbicide that affects thyroid
hormone activity (Ref. 10). In response to the
ITC’s request, the EPA added 3-amino-5mercapto-1,2,4-triazole to the July 24, 2000,
PAIR rule (Ref. 11) and the May 4, 2004
HaSDR rule (Ref. 5). Numerous studies were
submitted in response to the HaSDR rule.
These studies are summarized in this unit. 3Amino-5-mercapto-1,2,4-triazole was positive
in the mouse bone marrow micronucleus test,
clastogenic to rat lymphocytes, but not
mutagenic in the Ames assay using strains
TA98, 100, 1535, and 1537 or in the E. coli
assay, using strain WP2 uvrA-. 3-Amino-5mercapto-1,2,4-triazole was a mild eye and
skin irritant, but not a skin sensitizer. In a 4week inhalation study the no observed effect
level of 3-amino-5-mercapto-1,2,4-triazole
was 20 milligram/meter cubed (mg/m3).
3-Amino-5-mercapto-1,2,4-triazole is being
removed from the Priority Testing List
because information submitted in response to
the PAIR rule suggested that 3-amino-5mercapto-1,2,4-triazole is an on-site
intermediate and the production/importation
volumes were lower than the 250,000 pounds
of 3-amino-5-mercapto-1,2,4-triazole
imported into the United States in 1993 (Ref.
9).
2. Glycoluril. Glycoluril (CAS No. 496–46–
8) was also added to the Priority Testing List
in the ITC’s 42nd Report to obtain annual
production/importation volumes and trends,
use, exposure, and health effects data. The
addition was based on a potential for human
exposure and a suspicion of carcinogenicity
(Ref. 9). In response to the ITC’s request, the
EPA added glycoluril to the July 24, 2000
PAIR rule (Ref. 11) and the May 4, 2004
HaSDR rule (Ref. 5). No studies were
submitted in response to the HaSDR rule.
Glycoluril is being removed from the
Priority Testing List because information
submitted in response to the PAIR rule
suggested that glycoluril is an on-site
intermediate and the production/importation
volumes were less than the 10,000 to
1,000,000 pounds of non-CBI annual
production/importation volumes reported to
the EPA in 1986, 1990, and 1994 (Ref. 9).
3. Benzenamine, 3-chloro-2,6-dinitro-N,Ndipropyl-4-(trifluoromethyl)-. Benzenamine,
3-chloro-2,6-dinitro-N,N-dipropyl-4-
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(trifluoromethyl)- (aka 3-Chlorotrifluralin
(CAS No. 29091–20–1) was added to the
Priority Testing List in the ITC’s 48th Report
to obtain information on uses, exposures,
environmental releases, pharmacokinetics,
subchronic toxicity, mutagenicity,
reproductive and developmental effects,
carcinogenicity, and ecological effects (Ref.
12). Benzenamine, 3-chloro-2,6-dinitro-N,Ndipropyl-4-(trifluoromethyl)- was added to
the Priority Testing List because it has an
estimated bioconcentration factor (BCF) of
7,700 and is a chlorinated analog of
trifluralin (CAS No. 1582–09–8), the
herbicide that causes adverse effects in
experimental animals and is considered to be
a possible human carcinogen by the EPA
(Ref. 12).
In response to the ITC’s request, the EPA
added benzenamine, 3-chloro-2,6-dinitroN,N-dipropyl-4-(trifluoromethyl)- to the June
11, 2003 PAIR rule (Ref. 4) and the May 4,
2004 TSCA section 8(d) HaSDR rule (Ref. 5).
No information was submitted in response to
the PAIR or HaSDR rules. The ITC is
removing benzenamine, 3-chloro-2,6-dinitroN,N-dipropyl-4-(trifluoromethyl)- from the
Priority Testing List because the PAIR rule
did not provide any additional exposure
information implying that benzenamine, 3chloro-2,6-dinitro-N,N-dipropyl-4(trifluoromethyl)- is not produced at greater
than 1,000 pounds per site.
4. Stannane, dimethylbis[(1oxoneodecyl)oxy]-. Stannane, dimethylbis[(1oxoneodecyl)oxy]- (CAS No. 68928–76–7)
was added to the Priority Testing List in the
ITC’s 49th Report to obtain use, exposure,
environmental fate, health effects, and
ecological effects data (Ref. 13). Stannane,
dimethylbis[(1-oxoneodecyl)oxy]- was added
to the Priority Testing List because it has an
estimated BCF of 8,600 and signs of toxicity,
including neurotoxic effects that were
observed in a rat oral gavage study (Ref. 13).
In response to the ITC’s request, the EPA
added stannane, dimethylbis[(1oxoneodecyl)oxy]- to the June 11, 2003 PAIR
rule (Ref. 4) and the May 4, 2004 TSCA
section 8(d) HaSDR rule (Ref. 5). No
information was submitted in response to the
HaSDR rule. The ITC is removing stannane,
dimethylbis[(1-oxoneodecyl)oxy]- from the
Priority Testing List because the information
submitted in response to the PAIR rule
suggested that the production/importation
volumes of stannane, dimethylbis[(1oxoneodecyl)oxy]- were not greater than the
10,000–500,000 pounds of non-CBI
production/importation volumes reported to
the EPA in 2002 (https://www.epa.gov/oppt/
iur/iur02/index.htm/).
5. Benzene, 1,3,5-tribromo-2-(2propenyloxy)-. Benzene, 1,3,5-tribromo-2-(2propenyloxy)- (CAS No. 3278–89–5) was
added to the Priority Testing List in the ITC’s
50th Report to obtain use, exposure,
environmental fate, health effects, and
ecological effects data (Ref. 14). Benzene,
1,3,5-tribromo-2-(2-propenyloxy)- was added
to the Priority Testing List because of an
estimated BCF of 4,000 and potential for
exposure from its use as a flame retardant for
expanded polystyrene insulation board (Ref.
14).
In response to the ITC’s request, the EPA
added benzene, 1,3,5-tribromo-2-(2-
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propenyloxy)- to the June 11, 2003 PAIR rule
(Ref. 4) and the May 4, 2004 TSCA section
8(d) HaSDR rule (Ref. 5). Information
submitted in response to the HaSDR rule
indicated that the concentrated chemical may
be slightly irritating to the skin. The ITC is
removing benzene, 1,3,5-tribromo-2-(2propenyloxy)- from the Priority Testing List
because the information submitted in
response to the PAIR rule suggested that the
production/importation volumes of benzene,
1,3,5-tribromo-2-(2-propenyloxy)- were not
greater than 10,000–500,000 pounds of nonCBI production/importation volumes
reported to the EPA in 2002 (https://
www.epa.gov/oppt/iur/iur02/index.htm/).
6. 1-Triazene, 1,3-diphenyl-. 1-Triazene,
1,3-diphenyl- (aka diazoaminobenzene (CAS
No. 136–35–6) was added to the Priority
Testing List in the ITC’s 50th Report to obtain
annual production/importation volumes and
trends, use, exposure, and health effects data
(Ref. 14). 1-Triazene, 1,3-diphenyl- was
added to the Priority Testing List because it
is a predicted carcinogen based on its
metabolism and similarity in toxic effects to
benzene and aniline (Ref. 14).
In response to the ITC’s request, the EPA
added 1-triazene, 1,3-diphenyl- to the June
11, 2003 PAIR rule (Ref. 4) and the May 4,
2004 TSCA section 8(d) HaSDR rule (Ref. 5).
No information was submitted in response to
the PAIR or HaSDR rules. The ITC is
removing 1-triazene, 1,3-diphenyl- from the
Priority Testing List because the PAIR rule
did not provide any additional exposure
information implying that 1-triazene, 1,3diphenyl- is not produced at greater than
1,000 pounds per site.
V. References
1. EPA. 1998. Revisions to Reporting
Regulations Under TSCA Section 8(d). Direct
Final Rule. Federal Register (63 FR 15765,
April 1, 1998) (FRL–5750–4). Available
online at: https://www.epa.gov/fedrgstr/.
2. ITC. 2004. Fifty-Third Report of the ITC.
Federal Register (69 FR 2467, January 15,
2004) (FRL–7335–2). Available online at:
https://www.epa.gov/fedrgstr/.
3. EPA. 2004. Preliminary Assessment
Information Reporting; Addition of Certain
Chemicals. Final Rule. Federal Register (69
FR 70552, December 7, 2004) (FRL–7366–8).
Available online at: https://www.epa.gov/
fedrgstr/.
4. EPA. 2003. Preliminary Assessment
Information Reporting; Addition of Certain
Chemicals. Final Rule. Federal Register (68
FR 34832, June 11, 2003) (FRL–7306–7).
Available online at: https://www.epa.gov/
fedrgstr/.
5. EPA. 2004. Health and Safety Data
Reporting; Addition of Certain Chemicals.
Final Rule. Federal Register (69 FR 24517,
May 4, 2004) (FRL–7322–8). Available online
at: https://www.epa.gov/fedrgstr/.
6. ITC. 2003. Fifty-First Report of the ITC.
Federal Register (68 FR 8976, February 26,
2003) (FRL–7285–7). Available online at:
https://www.epa.gov/fedrgstr/.
7. ITC. 2004. Fifty-Fourth Report of the
ITC. Federal Register (69 FR 33527, June 15,
2004) (FRL–7359–6). Available online at:
https://www.epa.gov/fedrgstr/.
8. EPA. 2000. Testing of Certain High
Production Volume Chemicals. Proposed
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Rule. Federal Register (65 FR 81658,
December 26, 2000) (FRL–6758–4). Available
online at: https://www.epa.gov/fedrgstr/.
9. ITC. 1998. Forty-Second Report of the
ITC. Federal Register (63 FR 42554, August
7, 1998) (FRL–5797–8). Available online at:
https://www.epa.gov/fedrgstr/.
10. Takaoka, M., M. Teranishi, and S.
Manabe. 1994. Structure-Activity
Relationships in 5-Substituted 3-Amino1,2,4-Triazoles-Induced Goiters in Rats.
Journal of Toxicology and Pathology. 7:429–
434.
11. EPA. 2000. Preliminary Assessment
Information Reporting; Addition of Certain
Chemicals. Final Rule. Federal Register (65
FR 45535, July 24, 2000) (FRL–6597–3).
Available online at: https://www.epa.gov/
fedrgstr/.
12. ITC. 2001. Forty-Eighth Report of the
ITC. Federal Register (66 FR 51276, October
5, 2001) (FRL–6786–7). Available online at:
https://www.epa.gov/fedrgstr/.
13. ITC. 2002. Forty-Ninth Report of the
ITC. Federal Register (67 FR 10298, March 6,
2002) (FRL–6820–8). Available online at:
https://www.epa.gov/fedrgstr/.
14. ITC. 2002. Fiftieth Report of the ITC.
Federal Register (67 FR 49530, July 30, 2002)
(FRL–7183–7). Available online at: https://
www.epa.gov/fedrgstr/.
VI. The TSCA Interagency Testing
Committee
Statutory Organizations and Their
Representatives
Council on Environmental Quality
Vacant
Department of Commerce
Daphne Moffett, Member
National Institute of Standards and
Technology
Dianne Poster, Member
Peter Barker, Alternate
National Oceanographic and
AtmosphericAdministration
Thomas P. O’Connor, Member, Chair
Teri Rowles, Alternate
Environmental Protection Agency
Gerry Brown, Member
Paul Campanella, Alternate
National Cancer Institute
Alan Poland, Member
Shen Yang, Alternate
Consumer Product Safety Commission
Treye Thomas, Member
Jacqueline Ferrante, Alternate
Department of Agriculture
Clifford P. Rice, Member, Vice Chair
Laura L. McConnell, Alternate
Department of Defense
Warren Jederberg, Member
Department of the Interior
Barnett A. Rattner, Member
Food and Drug Administration
Kirk Arvidson, Alternate
Ronald F. Chanderbhan, Alternate
National Institute of Environmental Health
Sciences
Barbara Shane, Member
Scott Masten, Alternate
National Institute for Occupational Safety
and Health
Mark Toraason, Member
Dennis W. Lynch, Alternate
National Science Foundation
Marge Cavanaugh, Member
Parag R. Chitnis, Alternate
Occupational Safety and Health
Administration
Maureen Ruskin, Member
Liaison Organizations and Their
Representatives
Agency for Toxic Substances and Disease
Registry
National Library of Medicine
Vera W. Hudson, Member
National Toxicology Program
NIEHS, FDA, and NIOSH Members
Technical Support Contractor
Syracuse Research Corporation
ITC Staff
John D. Walker, Director
Norma S. L. Williams, Executive
Assistant
TSCA Interagency Testing Committee (7401),
Office of Pollution Prevention and Toxics,
Environmental Protection Agency, 1200
Pennsylvania Ave., NW., Washington, DC
20460–0001; e-mail address:
walker.johnd@epa.gov; url: https://
www.epa.gov/opptintr/itc/.
APPENDIX A—CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER (CAS NO.), TSCA INVENTORY NAMES AND PREVIOUS
TSCA SECTION 8(D) RULE SUNSET DATES OF HPV ORPHAN CHEMICALS FOR WHICH THE ITC IS REQUESTING THAT
THE EPA ADD TO TSCA SECTION 8(A) AND 8(D) RULES
CAS No.
Previous TSCA
section 8(d) rule
sunset date
TSCA Inventory Name
62–56–6
74–97–5
6/1/1997
Ethane, 1,1-dichloro-
6/1/1997
75–46–7
Methane, trifluoro-
77–76–9
Propane, 2,2-dimethoxy-
81–07–2
1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide
81–16–3
1-Naphthalenesulfonic acid, 2-amino-
81–84–5
1H,3H-Naphtho[1,8-cd]pyran-1,3-dione
83–41–0
Benzene, 1,2-dimethyl-3-nitro-
84–69–5
1,2-Benzenedicarboxylic acid, bis(2-methylpropyl) ester
85–40–5
1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-
90–43–7
[1,1’-Biphenyl]-2-ol
91–68–9
Phenol, 3-(diethylamino)-
94–75–7
16:41 Feb 10, 2005
Methane, bromochloro-
75–34–3
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APPENDIX A—CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER (CAS NO.), TSCA INVENTORY NAMES AND PREVIOUS
TSCA SECTION 8(D) RULE SUNSET DATES OF HPV ORPHAN CHEMICALS FOR WHICH THE ITC IS REQUESTING THAT
THE EPA ADD TO TSCA SECTION 8(A) AND 8(D) RULES—Continued
CAS No.
Previous TSCA
section 8(d) rule
sunset date
TSCA Inventory Name
94–96–2
1,3-Hexanediol, 2-ethyl-
95–94–3
Benzene, 1,2,4,5-tetrachloro-
96–22–0
3-Pentanone
96–23–1
2-Propanol, 1,3-dichloro-
97–00–7
Benzene, 1-chloro-2,4-dinitro-
98–09–9
Benzenesulfonyl chloride
98–16–8
Benzenamine, 3-(trifluoromethyl)-
98–56–6
Benzene, 1-chloro-4-(trifluoromethyl)-
99–51–4
Benzene, 1,2-dimethyl-4-nitro-
10/4/1992
4/29/1993
100–64–1
101–34–8
9-Octadecenoic
acid,
(9Z,9’Z,9’’Z,12R,12’R,12’’R)-
104–66–5
Benzene, 1,1’-[1,2-ethanediylbis(oxy)]bis-
104–93–8
Benzene, 1-methoxy-4-methyl-
107–39–1
1-Pentene, 2,4,4-trimethyl-
107–40–4
2-Pentene, 2,4,4-trimethyl-
107–45–9
2-Pentanamine, 2,4,4-trimethyl-
110–18–9
1,2-Ethanediamine, N,N,N’,N’-tetramethyl-
110–33–8
Hexanedioic acid, dihexyl ester
111–44–4
Ethane, 1,1’-oxybis[2-chloro-
111–85–3
Octane, 1-chloro-
111–91–1
Ethane, 1,1’-[methylenebis(oxy)]bis[2-chloro-
118–90–1
Benzoic acid, 2-methyl-
119–33–5
Phenol, 4-methyl-2-nitro-
6/30/1998
121–69–7
Benzenamine, N,N-dimethyl-
6/30/1998
121–82–4
1,3,5-Triazine, hexahydro-1,3,5-trinitro-
124–63–0
Methanesulfonyl chloride
127–68–4
Benzenesulfonic acid, 3-nitro-, sodium salt
131–57–7
Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-
137–20–2
Ethanesulfonic acid, 2-[methyl[(9Z)-1-oxo-9- octadecenyl]amino]-, sodium salt
138–25–0
1,3-Benzenedicarboxylic acid, 5-sulfo-, 1,3-dimethyl ester
139–40–2
1,3,5-Triazine-2,4-diamine, 6-chloro-N,N’-bis(1-methylethyl)-
140–08–9
Ethanol, 2-chloro-, phosphite (3:1)
140–93–2
Carbonodithioic acid, O-(1-methylethyl) ester, sodium salt
142–73–4
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APPENDIX A—CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER (CAS NO.), TSCA INVENTORY NAMES AND PREVIOUS
TSCA SECTION 8(D) RULE SUNSET DATES OF HPV ORPHAN CHEMICALS FOR WHICH THE ITC IS REQUESTING THAT
THE EPA ADD TO TSCA SECTION 8(A) AND 8(D) RULES—Continued
CAS No.
Previous TSCA
section 8(d) rule
sunset date
TSCA Inventory Name
150–50–5
307–35–7
1-Octanesulfonyl fluoride, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-
330–54–1
Urea, N’-(3,4-dichlorophenyl)-N,N-dimethyl-
460–00–4
Benzene, 1-bromo-4-fluoro-
506–51–4
1-Tetracosanol
506–52–5
1-Hexacosanol
513–74–6
Carbamodithioic acid, monoammonium salt
515–40–2
Benzene, (2-chloro-1,1-dimethylethyl)-
529–33–9
1-Naphthalenol, 1,2,3,4-tetrahydro-
529–34–0
1(2H)-Naphthalenone, 3,4-dihydro-
542–75–6
1-Propene, 1,3-dichloro-
542–92–7
1,3-Cyclopentadiene
557–61–9
1-Octacosanol
563–72–4
Ethanedioic acid, calcium salt (1:1)
579–66–8
Benzenamine, 2,6-diethyl-
590–19–2
1,2-Butadiene
592–45–0
1,4-Hexadiene
597–31–9
Propanal, 3-hydroxy-2,2-dimethyl-
598–72–1
Propanoic acid, 2-bromo-
617–94–7
Benzenemethanol, .alpha.,.alpha.-dimethyl-
625–55–8
Formic acid, 1-methylethyl ester
628–13–7
Pyridine, hydrochloride
628–96–6
1,2-Ethanediol, dinitrate
645–62–5
2-Hexenal, 2-ethyl-
693–07–2
Ethane, 1-chloro-2-(ethylthio)-
693–95–8
Thiazole, 4-methyl-
756–80–9
Phosphorodithioic acid, O,O-dimethyl ester
870–72–4
Methanesulfonic acid, hydroxy-, monosodium salt
928–72–3
Glycine, N-(carboxymethyl)-, disodium salt
939–97–9
Benzaldehyde, 4-(1,1-dimethylethyl)-
11/9/1993
1000–82–4
Urea, (hydroxymethyl)-
7/1/1993
1002–69–3
Decane, 1-chloro-
1111–78–0
Carbamic acid, monoammonium salt
1115–20–4
Propanoic acid, 3-hydroxy-2,2-dimethyl-, 3-hydroxy-2,2-dimethylpropyl ester
1401–55–4
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APPENDIX A—CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER (CAS NO.), TSCA INVENTORY NAMES AND PREVIOUS
TSCA SECTION 8(D) RULE SUNSET DATES OF HPV ORPHAN CHEMICALS FOR WHICH THE ITC IS REQUESTING THAT
THE EPA ADD TO TSCA SECTION 8(A) AND 8(D) RULES—Continued
CAS No.
Previous TSCA
section 8(d) rule
sunset date
TSCA Inventory Name
1445–45–0
1459–93–4
1,3-Benzenedicarboxylic acid, dimethyl ester
1498–51–7
Phosphorodichloridic acid, ethyl ester
1558–33–4
Silane, dichloro(chloromethyl)methyl-
1646–75–9
Propanal, 2-methyl-2-(methylthio)-, oxime
1691–99–2
1-Octanesulfonamide,
(2-hydroxyethyl)-
1738–25–6
Propanenitrile, 3-(dimethylamino)-
1912–24–9
1,3,5-Triazine-2,4-diamine, 6-chloro-N-ethyl-N’-(1-methylethyl)-
1918–02–1
2-Pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-
1929–82–4
Pyridine, 2-chloro-6-(trichloromethyl)-
2152–64–9
Benzenamine,
N-phenyl-4-[[4-(phenylamino)phenyl][4-(phenylimino)-2,5cyclohexadien-1-ylidene]methyl]-, monohydrochloride
2210–79–9
Oxirane, [(2-methylphenoxy)methyl]-
2372–45–4
1-Butanol, sodium salt
2409–55–4
Phenol, 2-(1,1-dimethylethyl)-4-methyl-
2425–54–9
Tetradecane, 1-chloro-
2494–89–5
Ethanol, 2-[(4-aminophenyl)sulfonyl]-, hydrogen sulfate (ester)
2524–03–0
Phosphorochloridothioic acid, O,O-dimethyl ester
2611–00–9
3-Cyclohexene-1-carboxylic acid, 3-cyclohexen-1-ylmethyl ester
2691–41–0
1,3,5,7-Tetrazocine, octahydro-1,3,5,7-tetranitro-
2702–72–9
Acetic acid, (2,4-dichlorophenoxy)-, sodium salt
2814–20–2
4(1H)-Pyrimidinone, 6-methyl-2-(1-methylethyl)-
2905–62–6
Benzoyl chloride, 3,5-dichloro-
2915–53–9
2-Butenedioic acid (2Z)-, dioctyl ester
3039–83–6
Ethenesulfonic acid, sodium salt
3088–31–1
Ethanol, 2-[2-(dodecyloxy)ethoxy]-, hydrogen sulfate, sodium salt
3132–99–8
Benzaldehyde, 3-bromo-
3338–24–7
Phosphorodithioic acid, O,O-diethyl ester, sodium salt
3386–33–2
Octadecane, 1-chloro-
3586–14–9
Benzene, 1-methyl-3-phenoxy-
3710–84–7
Ethanamine, N-ethyl-N-hydroxy-
3779–63–3
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(6-isocyanatohexyl)-
3965–55–7
1,3-Benzenedicarboxylic acid, 5-sulfo-, 1,3-dimethyl ester, sodium salt
4035–89–6
Imidodicarbonic diamide, N,N’,2-tris(6-isocyanatohexyl)-
4080–31–3
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APPENDIX A—CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER (CAS NO.), TSCA INVENTORY NAMES AND PREVIOUS
TSCA SECTION 8(D) RULE SUNSET DATES OF HPV ORPHAN CHEMICALS FOR WHICH THE ITC IS REQUESTING THAT
THE EPA ADD TO TSCA SECTION 8(A) AND 8(D) RULES—Continued
CAS No.
Previous TSCA
section 8(d) rule
sunset date
TSCA Inventory Name
4170–30–3
2-Butenal
4300–97–4
Propanoyl chloride, 3-chloro-2,2-dimethyl-
4316–73–8
Glycine, N-methyl-, monosodium salt
4860–03–1
Hexadecane, 1-chloro-
5026–74–4
Oxiranemethanamine, N-[4-(oxiranylmethoxy)phenyl]-N- (oxiranylmethyl)-
5216–25–1
Benzene, 1-chloro-4-(trichloromethyl)-
5460–09–3
2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-, monosodium salt
5915–41–3
1,3,5-Triazine-2,4-diamine, 6-chloro-N-(1,1-dimethylethyl)-N’-ethyl-
6473–13–8
2-Naphthalenesulfonic
acid,
6-[(2,4-diaminophenyl)azo]-3-[[4-[[4-[[7-[(2,4diaminophenyl)azo]-1-hydroxy-3-sulfo-2-naphthalenyl]azo]phenyl]amino]-3sulfophenyl]azo]-4-hydroxy-, trisodium salt
6863–58–7
Butane, 2,2’-oxybis-
6865–35–6
Octadecanoic acid, barium salt
7320–37–8
Oxirane, tetradecyl-
7446–81–3
2-Propenoic acid, sodium salt
7795–95–1
1-Octanesulfonyl chloride
8001–58–9
Creosote
10/40/1992
10265–69–7
13749–94–5
Ethanimidothioic acid, N-hydroxy-, methyl ester
13826–35–2
Benzenemethanol, 3-phenoxy-
14143–60–3
2-Pyridinecarbonitrile, 4-amino-3,5,6-trichloro-
14666–94–5
9-Octadecenoic acid (9Z)-, cobalt salt
17103–31–0
Urea, sulfate (2:1)
17321–47–0
Phosphoramidothioic acid, O,O-dimethyl ester
17976–43–1
2,4,6,8,3,5,7-Benzotetraoxatriplumbacycloundecin-3,5,7-triylidene,
dioxo-
19438–61–0
1,3-Isobenzofurandione, 5-methyl-
19525–59–8
Glycine, N-phenyl-, monopotassium salt
20068–02–4
2-Butenenitrile, 2-methyl-, (2Z)-
20227–53–6
Phosphorous
acid,
2-(1,1-dimethylethyl)-4-[1-[3-(1,1-dimethylethyl)-4hydroxyphenyl]-1-methylethyl]phenyl bis(4-nonylphenyl) ester
20469–71–0
Hydrazinecarbodithioic acid, compd. with hydrazine (1:1)
21351–39–3
Urea, sulfate (1:1)
22527–63–5
Propanoic acid, 2-methyl-, 3-(benzoyloxy)-2,2,4-trimethylpentyl ester
24448–09–7
1-Octanesulfonamide, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8droxyethyl)-N-methyl-
24615–84–7
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APPENDIX A—CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER (CAS NO.), TSCA INVENTORY NAMES AND PREVIOUS
TSCA SECTION 8(D) RULE SUNSET DATES OF HPV ORPHAN CHEMICALS FOR WHICH THE ITC IS REQUESTING THAT
THE EPA ADD TO TSCA SECTION 8(A) AND 8(D) RULES—Continued
CAS No.
Previous TSCA
section 8(d) rule
sunset date
TSCA Inventory Name
24794–58–9
25154–38–5
Piperazineethanol
25168–05–2
Benzene, chloromethyl-
25168–06–3
Phenol, (1-methylethyl)-
25321–41–9
Benzenesulfonic acid, dimethyl-
25383–99–7
Octadecanoic acid, 2-(1-carboxyethoxy)-1-methyl-2-oxoethyl ester, sodium salt
25586–42–9
Phosphorous acid, tris(methylphenyl) ester
25646–71–3
Methanesulfonamide, N-[2-[(4-amino-3-methylphenyl)ethylamino]ethyl]-, sulfate (2:3)
26377–29–7
Phosphorodithioic acid, O,O-dimethyl ester, sodium salt
26401–27–4
Phosphorous acid, isooctyl diphenyl ester
26680–54–6
2,5-Furandione, dihydro-3-(octenyl)-
27193–28–8
Phenol, (1,1,3,3-tetramethylbutyl)-
28106–30–1
Benzene, ethenylethyl-
28188–24–1
Octadecanoic
acid,
propanediyl ester
28777–98–2
2,5-Furandione, dihydro-3-(octadecenyl)-
28908–00–1
Benzothiazole, 2-[(chloromethyl)thio]-
30574–97–1
2-Butenenitrile, 2-methyl-, (2E)-
32072–96–1
2,5-Furandione, 3-(hexadecenyl)dihydro-
33509–43–2
1,2,4-Triazin-5(2H)-one, 4-amino-6-(1,1-dimethylethyl)-3,4-dihydro-3-thioxo-
34689–46–8
Phenol, methyl-, sodium salt
35203–06–6
Benzenamine, 2-ethyl-6-methyl-N-methylene-
35203–08–8
Benzenamine, 2,6-diethyl-N-methylene-
37439–34–2
2(1H)-Pyridinone, 3,5,6-trichloro-, sodium salt
37734–45–5
Carbonochloridothioic acid, S-(phenylmethyl) ester
37764–25–3
Acetamide, 2,2-dichloro-N,N-di-2-propenyl-
38185–06–7
Benzenesulfonic acid, 4-chloro-3,5-dinitro-, potassium salt
38321–18–5
Ethanol, 2-(2-butoxyethoxy)-, sodium salt
39515–51–0
Benzaldehyde, 3-phenoxy-
40630–63–5
1-Octanesulfonyl fluoride
40876–98–0
Butanedioic acid, oxo-, diethyl ester, ion(1-), sodium
51632–16–7
Benzene, 1-(bromomethyl)-3-phenoxy-
52184–19–7
Phenol, 2,4-bis(1,1-dimethylpropyl)-6-[(2- nitrophenyl)azo]-
52556–42–0
1-Propanesulfonic acid, 2-hydroxy-3-(2-propenyloxy)-, monosodium salt
52663–57–7
VerDate jul<14>2003
Formic acid, compd. with 2,2’,2’’-nitrilotris[ethanol] (1:1)
Ethanol, 2-butoxy-, sodium salt
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APPENDIX A—CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER (CAS NO.), TSCA INVENTORY NAMES AND PREVIOUS
TSCA SECTION 8(D) RULE SUNSET DATES OF HPV ORPHAN CHEMICALS FOR WHICH THE ITC IS REQUESTING THAT
THE EPA ADD TO TSCA SECTION 8(A) AND 8(D) RULES—Continued
CAS No.
Previous TSCA
section 8(d) rule
sunset date
TSCA Inventory Name
56038–89–2
56803–37–3
Phosphoric acid, (1,1-dimethylethyl)phenyl diphenyl ester
57693–14–8
Chromate(3-),
bis[3-(hydroxy-.kappa.O)-4-[[2-(hydroxy-.kappa.O)-1naphthalenyl]azo-.kappa.N1]-7-nitro-1-naphthalenesulfonato(3-)]-, trisodium
61788–76–9
Alkanes, chloro
61789–32–0
Fatty acids, coco, 2-sulfoethyl esters, sodium salts
61789–85–3
Sulfonic acids, petroleum
63302–49–8
Phosphorochloridous acid, bis(4-nonylphenyl) ester
64742–24–1
Sludges (petroleum), acid
64743–02–8
Alkenes, C>10 .alpha.-
64743–03–9
Phenols (petroleum)
64771–71–7
Paraffins (petroleum), normal C>10
65996–79–4
Solvent naphtha (coal)
65996–80–7
Ammonia liquor (coal)
65996–81–8
Fuel gases, coke-oven
65996–82–9
Tar oils, coal
65996–83–0
Extracts, coal tar oil alk.
65996–86–3
Extract oils (coal), tar base
65996–87–4
Extract residues (coal), tar oil alk.
65996–89–6
Tar, coal, high-temp.
65996–91–0
Distillates (coal tar), upper
65996–92–1
Distillates (coal tar)
66071–94–1
Corn, steep liquor
68081–86–7
Phenol, nonyl derivs.
68082–78–0
Lard, oil, Me esters
68153–60–6
Fatty acids, tall-oil, reaction products with diethylenetriamine, acetates
68187–41–7
Phosphorodithioic acid, O,O-di-C1-14-alkyl esters
68187–57–5
Pitch, coal tar-petroleum
68187–59–7
Coal, anthracite, calcined
68188–18–1
Paraffin oils, chlorosulfonated, saponified
68308–74–7
Amides, tall-oil fatty, N,N-di-Me
68309–16–0
Fatty acids, tall-oil, 2-(2-hydroxyethoxy)ethyl esters
68309–27–3
Fatty acids, tall-oil, sulfonated, sodium salts
68334–01–0
Disulfides, alkylaryl dialkyl diaryl, petroleum refinery spent caustic oxidn. products
68441–66–7
VerDate jul<14>2003
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Decanoic acid, mixed esters with dipentaerythritol, octanoic acid and valeric acid
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APPENDIX A—CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER (CAS NO.), TSCA INVENTORY NAMES AND PREVIOUS
TSCA SECTION 8(D) RULE SUNSET DATES OF HPV ORPHAN CHEMICALS FOR WHICH THE ITC IS REQUESTING THAT
THE EPA ADD TO TSCA SECTION 8(A) AND 8(D) RULES—Continued
CAS No.
Previous TSCA
section 8(d) rule
sunset date
TSCA Inventory Name
68442–60–4
68442–77–3
2-Butenediamide,
yl)ethyl] derivs.
68476–80–2
Fats and Glyceridic oils, vegetable, deodorizer distillates
68478–20–6
Residues (petroleum), steam-cracked petroleum distillates cyclopentadiene conc.,
C4-cyclopentadiene-free
68512–63–0
Benzene, ethenyl-, distn. residues
68513–62–2
Disulfides, C5-12-alkyl
68514–41–0
Ketones, C12-branched
68515–89–9
Barium, carbonate nonylphenol complexes
68584–25–8
Benzenesulfonic acid, C10-16-alkyl derivs., compds. with triethanolamine
68602–81–3
Distillates, hydrocarbon resin prodn. higher boiling
68603–84–9
Carboxylic acids, C5-9
68608–59–3
Ethane, 1,2-dichloro-, manuf. of, by-products from, distn. lights
68609–05–2
Cyclohexane, oxidized, non-acidic by-products, distn. lights
68610–90–2
2-Butenedioic acid (2E)-, di-C8-18-alkyl esters
68649–42–3
Phosphorodithioic acid, O,O-di-C1-14-alkyl esters
68650–36–2
Aromatic hydrocarbons, C8, o-xylene-lean
68782–97–8
Distillates (petroleum), hydrofined lubricating-oil
68815–50–9
Octadecanoic acid, reaction products with 2-[(2-aminoethyl)amino]ethanol
68909–77–3
Ethanol, 2,2’-oxybis-, reaction products with ammonia, morpholine derivs. residues
68915–05–9
Fatty acids, tall-oil, low-boiling, reaction products with ammonia-ethanolamine reaction by-products
68915–39–9
Cyclohexane, oxidized, aq. ext., sodium salt
68918–16–1
Tar, coal, dried and oxidized
68919–17–5
Hydrocarbons, C12-20, catalytic alkylation by-products
68920–64–9
Disulfides, di-C1-2-alkyl
68937–29–1
1,6-Hexanediol, distn. residues
68937–69–9
Carboxylic acids, C6-18 and C5-15-di-
68937–70–2
Carboxylic acids, C6-18 and C8-15-di-
68937–72–4
Carboxylic acids, di-, C4-11
68953–70–8
Oxirane, reaction products with ammonia, distn. residues
68953–80–0
Benzene, mixed with toluene, dealkylation product
68955–37–3
Acid chlorides, tallow, hydrogenated
68955–76–0
Aromatic hydrocarbons, C9-16, biphenyl deriv.-rich
68955–96–4
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Disulfides, dialkyl and di-Ph, naphtha sweetening
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7377
APPENDIX A—CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER (CAS NO.), TSCA INVENTORY NAMES AND PREVIOUS
TSCA SECTION 8(D) RULE SUNSET DATES OF HPV ORPHAN CHEMICALS FOR WHICH THE ITC IS REQUESTING THAT
THE EPA ADD TO TSCA SECTION 8(A) AND 8(D) RULES—Continued
CAS No.
Previous TSCA
section 8(d) rule
sunset date
TSCA Inventory Name
68987–41–7
Benzene, ethylenated
68987–66–6
Ethene, hydrated, by-products from
68988–22–7
1,4-Benzenedicarboxylic acid, dimethyl ester, manuf. of, by-products from
68988–99–8
Phenols, sodium salts, mixed with sulfur compounds, gasoline alk. scrubber residues
68990–61–4
Tar, coal, high-temp., high-solids
68990–65–8
Fats and Glyceridic oils, vegetable, reclaimed
70024–67–8
Benzenesulfonic acid, C16-24-alkyl derives.
70084–98–9
Terpenes and Terpenoids, C10-30, distn. residues
70693–50–4
Phenol, 2,4-bis(1-methyl-1-phenylethyl)-6-[(2- nitrophenyl)azo]-
70851–08–0
Amides, coco, N-[3-(dimethylamino)propyl], alkylation products with sodium 3chloro-2-hydroxypropanesulfonate
71077–05–9
Ethanol, 2,2’-oxybis-, reaction products with ammonia, morpholine product tower
residues
72162–28–8
2-Propanone, reaction products with phenol
72854–27–4
Tannins, reaction products with sodium bisulfite, sodium polysulfide and sodium
sulfite
73665–18–6
Extract residues (coal), tar oil alk., naphthalene distn. residues
83864–02–2
Nickel, bis[(cyano-C)triphenylborato(1-)-N]bis(hexanedinitrile-N,N’)-
84501–86–0
Hexanedioic acid, esters with high-boiling C6-10-alkene hydroformylation products
90640–80–5
Anthracene oil
90640–86–1
Distillates (coal tar), heavy oils
119345–02–7
Benzene, 1,1’-oxybis-, tetrapropylene derivs.
125997–20–8
Phosphoric acid, mixed 3-bromo-2,2-dimethylpropyl and 2-bromoethyl and 2chloroethyl esters
[FR Doc. 05–2714 Filed 2–10–05; 8:45 am]
BILLING CODE 6560–50–S
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]]>Agencies
[Federal Register Volume 70, Number 28 (Friday, February 11, 2005)]
[NOT]
[Pages 7364-7377]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 05-2714]
[[Page 7363]]
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Part IV
Environmental Protection Agency
-----------------------------------------------------------------------
Fifty-Fifth Report of the TSCA Interagency Testing Committee to the
Administrator of the Environmental Protection Agency; Receipt of Report
and Request for Comments; Notice
Federal Register / Vol. 70, No. 28 / Friday, February 11, 2005 /
Notices
[[Page 7364]]
-----------------------------------------------------------------------
ENVIRONMENTAL PROTECTION AGENCY
[OPPT-2004-0130; FRL-7692-1]
Fifty-Fifth Report of the TSCA Interagency Testing Committee to
the Administrator of the Environmental Protection Agency; Receipt of
Report and Request for Comments
AGENCY: Environmental Protection Agency (EPA).
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The Toxic Substances Control Act (TSCA) Interagency Testing
Committee (ITC) transmitted its Fifty-Fifth Report to the Administrator
of EPA on December 8, 2004. In the 55\th\ ITC Report, which is included
with this notice, the ITC is revising the Priority Testing List by
adding a category of high production volume (HPV) orphan chemicals and
requesting that EPA add these chemicals to the TSCA section 8(a)
Preliminary Assessment Information Reporting (PAIR) rule and the TSCA
section 8(d) Health and Safety Data Reporting (HaSDR) rule. The ITC is
also removing the following chemicals from the Priority Testing List:
3-amino-5-mercapto-1,2,4-triazole; glycoluril; benzenamine, 3-chloro-
2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)-; stannane,
dimethylbis[(1-oxoneodecyl)oxy]-; benzene, 1,3,5-tribromo-2-(2-
propenyloxy)-; and1-triazene, 1,3-diphenyl-.]. Since the 55\th\ Report
was ITC transmitted to the Administrator and made publicly available on
https://www.epa.gov/opptintr/itc/, five HPV orphan chemicals have been
removed from the Priority Testing List because chemical manufacturers
committed to prepare robust summaries for these chemicals in response
to the HPV Challenge Program. The ITC encourages other manufacturers to
make similar commitments so their chemicals can be removed from the
Priority Testing List and potentially avoid being added to PAIR and
HaSDR rules.
DATES: Comments, identified by docket identification (ID) number OPPT-
2004-0130, must be received on or before March 14, 2005.
ADDRESSES: Comments may be submitted electronically, by mail, or
through hand delivery/courier. Follow the detailed instructions as
provided in Unit I. of the SUPPLEMENTARY INFORMATION.
FOR FURTHER INFORMATION CONTACT: For general information contact:
Colby Lintner, Regulatory Coordinator, Environmental Assistance
Division (7408M), Office of Pollution Prevention and Toxics,
Environmental Protection Agency, 1200 Pennsylvania Ave., NW.,
Washington, DC 20460-0001; telephone number: (202) 554-1404; e-mail
address: TSCA-Hotline@epa.gov.
For technical information contact: John D. Walker, Director, TSCA
Interagency Testing Committee (7401), Office of Pollution Prevention
and Toxics, Environmental Protection Agency, 1200 Pennsylvania Ave.,
NW., Washington, DC 20460-0001; e-mail address: walker.johnd@epa.gov.
SUPPLEMENTARY INFORMATION:
I. General Information
A. Does this Action Apply to Me?
This notice is directed to the public in general. It may, however,
be of particular interest to you if you manufacture (defined by statute
to include import) and/or process TSCA-covered chemicals and you may be
identified by the North American Industrial Classification System
(NAICS) codes 325 and 32411. Because this notice is directed to the
general public and other entities may also be interested, the Agency
has not attempted to describe all the specific entities that may be
interested in this action. If you have any questions regarding the
applicability of this action to a particular entity, consult the
technical person listed under FOR FURTHER INFORMATION CONTACT.
B. How Can I Get Copies of this Document and Other Related Information?
1. Docket. EPA has established an official public docket for this
action under docket ID number OPPT-2004-0130. The official public
docket consists of the documents specifically referenced in this
action, any public comments received, and other information related to
this action. Although a part of the official docket, the public docket
does not include Confidential Business Information (CBI) or other
information whose disclosure is restricted by statute. The official
public docket is the collection of materials that is available for
public viewing at the EPA Docket Center, Rm. B102-Reading Room, EPA
West, 1301 Constitution Ave., NW., Washington, DC. The EPA Docket
Center is open from 8:30 a.m. to 4:30 p.m., Monday through Friday,
excluding legal holidays. The EPA Docket Center Reading Room telephone
number is (202) 566-1744 and the telephone number for the OPPT Docket,
which is located in EPA Docket Center, is (202) 566-0280.
2. Electronic access. You may access this Federal Register document
electronically through the EPA Internet under the ``Federal Register''
listings at https://www.epa.gov/fedrgstr/. You may also access
additional information about the ITC at https://www.epa.gov/opptintr/
itc/ or through the web site for the Office of Prevention, Pesticides
and Toxic Substances (OPPTS) at https://www.epa.gov/opptsfrs/home/
opptsim.htm/.
An electronic version of the public docket is available through
EPA's electronic public docket and comment system, EPA Dockets. You may
use EPA Dockets at https://www.epa.gov/edocket/ to submit or view public
comments, access the index listing of the contents of the official
public docket, and to access those documents in the public docket that
are available electronically. Although not all docket materials may be
available electronically, you may still access any of the publicly
available docket materials through the docket facility identified in
Unit I.B.1. Once in the system, select ``search,'' then key in the
appropriate docket ID number.
Certain types of information will not be placed in the EPA Dockets.
Information claimed as CBI and other information whose disclosure is
restricted by statute, which is not included in the official public
docket, will not be available for public viewing in EPA's electronic
public docket. EPA's policy is that copyrighted material will not be
placed in EPA's electronic public docket but will be available only in
printed, paper form in the official public docket. To the extent
feasible, publicly available docket materials will be made available in
EPA's electronic public docket. When a document is selected from the
index list in EPA Dockets, the system will identify whether the
document is available for viewing in EPA's electronic public docket.
Although not all docket materials may be available electronically, you
may still access any of the publicly available docket materials through
the docket facility identified in Unit I.B.1. EPA intends to work
towards providing electronic access to all of the publicly available
docket materials through EPA's electronic public docket.
For public commenters, it is important to note that EPA's policy is
that public comments, whether submitted electronically or in paper,
will be made available for public viewing in EPA's electronic public
docket as EPA receives them and without change, unless the comment
contains copyrighted material, CBI, or other information whose
disclosure is restricted by statute. When EPA identifies a comment
containing copyrighted material, EPA will provide
[[Page 7365]]
a reference to that material in the version of the comment that is
placed in EPA's electronic public docket. The entire printed comment,
including the copyrighted material, will be available in the public
docket.
Public comments submitted on computer disks that are mailed or
delivered to the docket will be transferred to EPA's electronic public
docket. Public comments that are mailed or delivered to the docket will
be scanned and placed in EPA's electronic public docket. Where
practical, physical objects will be photographed, and the photograph
will be placed in EPA's electronic public docket along with a brief
description written by the docket staff.
C. How and to Whom Do I Submit Comments?
You may submit comments electronically, by mail, or through hand
delivery/courier. To ensure proper receipt by EPA, identify the
appropriate docket ID number in the subject line on the first page of
your comment. Please ensure that your comments are submitted within the
specified comment period. Comments received after the close of the
comment period will be marked ``late.'' EPA is not required to consider
these late comments. If you wish to submit CBI or information that is
otherwise protected by statute, please follow the instructions in Unit
I.D. Do not use EPA Dockets or e-mail to submit CBI or information
protected by statute.
1. Electronically. If you submit an electronic comment as
prescribed in this unit, EPA recommends that you include your name,
mailing address, and an e-mail address or other contact information in
the body of your comment. Also include this contact information on the
outside of any disk or CD ROM you submit, and in any cover letter
accompanying the disk or CD ROM. This ensures that you can be
identified as the submitter of the comment and allows EPA to contact
you in case EPA cannot read your comment due to technical difficulties
or needs further information on the substance of your comment. EPA's
policy is that EPA will not edit your comment, and any identifying or
contact information provided in the body of a comment will be included
as part of the comment that is placed in the official public docket,
and made available in EPA's electronic public docket. If EPA cannot
read your comment due to technical difficulties and cannot contact you
for clarification, EPA may not be able to consider your comment.
i. EPA Dockets. Your use of EPA's electronic public docket to
submit comments to EPA electronically is EPA's preferred method for
receiving comments. Go directly to EPA Dockets at https://www.epa.gov/
edocket/, and follow the online instructions for submitting comments.
Once in the system, select ``search,'' and then key in docket ID number
OPPT-2004-0130. The system is an `` anonymous access'' system, which
means EPA will not know your identity, e-mail address, or other contact
information unless you provide it in the body of your comment.
ii. E-mail. Comments may be sent by e-mail to oppt.ncic@epa.gov,
Attention: Docket ID Number OPPT-2004-0130. In contrast to EPA's
electronic public docket, EPA's e-mail system is not an ``anonymous
access'' system. If you send an e-mail comment directly to the docket
without going through EPA's electronic public docket, EPA's e-mail
system automatically captures your e-mail address. E-mail addresses
that are automatically captured by EPA's e-mail system are included as
part of the comment that is placed in the official public docket, and
made available in EPA's electronic public docket.
iii. Disk or CD ROM. You may submit comments on a disk or CD ROM
that you mail to the mailing address identified in Unit I.C.2. These
electronic submissions will be accepted in WordPerfect or ASCII file
format. Avoid the use of special characters and any form of encryption.
2. By mail. Send your comments to: Document Control Office (7407M),
Office of Pollution Prevention and Toxics (OPPT), Environmental
Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-
0001.
3. By hand delivery or courier. Deliver your comments to: OPPT
Document Control Office (DCO), EPA East Bldg., Rm. 6428, 1201
Constitution Ave., NW., Washington, DC. Attention: Docket ID Number
OPPT-2004-0130. The DCO is open from 8 a.m. to 4 p.m., Monday through
Friday, excluding legal holidays. The telephone number for the DCO is
(202) 564-8930.
D. How Should I Submit CBI to the Agency?
Do not submit information that you consider to be CBI
electronically through EPA's electronic public docket or by e-mail. You
may claim information that you submit to EPA as CBI by marking any part
or all of that information as CBI (if you submit CBI on disk or CD ROM,
mark the outside of the disk or CD ROM as CBI and then identify
electronically within the disk or CD ROM the specific information that
is CBI). Information so marked will not be disclosed except in
accordance with procedures set forth in 40 CFR part 2.
In addition to one complete version of the comment that includes
any information claimed as CBI, a copy of the comment that does not
contain the information claimed as CBI must be submitted for inclusion
in the public docket and EPA's electronic public docket. If you submit
the copy that does not contain CBI on disk or CD ROM, mark the outside
of the disk or CD ROM clearly that it does not contain CBI. Information
not marked as CBI will be included in the public docket and EPA's
electronic public docket without prior notice. If you have any
questions about CBI or the procedures for claiming CBI, please consult
the technical person listed under FOR FURTHER INFORMATION CONTACT.
E. What Should I Consider as I Prepare My Comments for EPA?
We invite you to provide your views and comments on the ITC's
55\th\ Report. You may find the following suggestions helpful for
preparing your comments:
1. Explain your views as clearly as possible.
2. Describe any assumptions that you used.
3. Provide copies of any technical information and/or data you used
that support your views.
4. Provide specific examples to illustrate your concerns.
5. Make sure to submit your comments by the deadline in this
notice.
6. To ensure proper receipt by EPA, be sure to identify the docket
ID number assigned to this action in the subject line on the first page
of your response. You may also provide the name, date, and Federal
Register citation.
II. Background
The Toxic Substances Control Act (TSCA) (15 U.S.C. 260l et seq.)
authorizes the Administrator of the EPA to promulgate regulations under
section 4(a) of TSCA requiring testing of chemicals and chemical groups
in order to develop data relevant to determining the risks that such
chemicals and chemical groups may present to health or the environment.
Section 4(e) of TSCA established the ITC to recommend chemicals and
chemical groups to the Administrator of the EPA for priority testing
consideration. Section 4(e) of TSCA directs the ITC to revise the TSCA
section 4(e) Priority Testing List at least every 6 months.
A. The ITC's 55\th\ Report
The 55\th\ ITC Report was transmitted to EPA's Administrator on
December 8,
[[Page 7366]]
2004, and is included in this notice. In the 55\th\ ITC Report, the ITC
is revising the Priority Testing List by adding a category of HPV
orphan chemicals and requesting that EPA add these chemicals to the
TSCA section 8(a) PAIR rule and the TSCA section 8(d) HaSDR rule. The
ITC is also removing the following chemicals from the Priority Testing
List: 3-amino-5-mercapto-1,2,4-triazole; glycoluril; benzenamine, 3-
chloro-2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)-; stannane,
dimethylbis[(1-oxoneodecyl)oxy]-; benzene, 1,3,5-tribromo-2-(2-
propenyloxy)-; and 1-triazene, 1,3-diphenyl-.
B. Status of the Priority Testing List
The current TSCA 4(e) Priority Testing List as of December 2004 can
be found in Table 1 of the 55\th\ ITC Report, which is included in this
notice.
List of Subjects
Environmental protection, Chemicals, Hazardous substances.
Dated: February 3, 2005.
Charles M. Auer,
Director, Office of Pollution Prevention and Toxics.
Fifty-Fifth Report of the TSCA Interagency Testing Committee to the
Administrator, U.S. Environmental Protection Agency
Table of Contents
Summary
I. Background
II. TSCA Section 8 Reporting
A. TSCA Ssection 8 Reporting Rules
B. ITC's Use of TSCA Section 8 and Other Information
C. Previous Requests to Add Chemicals to the TSCA Section 8(a) PAIR
Rule
D. New Requests to Add Chemicals to the TSCA Section 8(a) PAIR and
8(d) HaSDR Rules
III. ITC's Activities During this Reporting Period (May to November
2004)
IV. Revisions to the TSCA Section 4(e) Priority Testing List
A. Chemicals Added to the Priority Testing List: HPV Orphan
Chemicals
B. Chemicals Removed From the Priority Testing List
1. 3-Amino-5-mercapto-1,2,4-triazole.
2. Glycoluril.
3. Benzenamine, 3-chloro-2,6-dinitro-N,N-dipropyl-4-
(trifluoromethyl)-.
4. Stannane, dimethylbis[(1-oxoneodecyl)oxy]-.
5. Benzene, 1,3,5-tribromo-2-(2-propenyloxy)-.
6. 1-Triazene, 1,3-diphenyl-.
V. References
VI. The TSCA Interagency Testing Committee
Summary
In this 55\th\ ITC Report, the ITC is revising the Priority
Testing List by adding a category of High Production Volume (HPV)
orphan chemicals and requesting that EPA add these chemicals to the
Toxic Substances Control Act (TSCA) section 8(a) Preliminary
Assessment Information Reporting (PAIR) rule and the TSCA section
8(d) Health and Safety Data Reporting (HaSDR) rule. The ITC is also
removing the following chemicals from the Priority Testing List: 3-
amino-5-mercapto-1,2,4-triazole; glycoluril; benzenamine, 3-chloro-
2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)-; stannane,
dimethylbis[(1-oxoneodecyl)oxy]-; benzene, 1,3,5-tribromo-2-(2-
propenyloxy)-; and 1-triazene, 1,3-diphenyl-.
The TSCA section 4(e) Priority Testing List is Table 1 of this
unit.
Table 1.--The TSCA Section 4(e) Priority Testing List (November 2004)
----------------------------------------------------------------------------------------------------------------
ITC Report Date Chemical name/group Action
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31 January 1993 13 Chemicals with Designated
insufficient dermal
absorption rate data
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I. Background
The ITC was established by section 4(e) of TSCA ``to make
recommendations to the Administrator respecting the chemical
substances and mixtures to which the Administrator should give
priority consideration for the promulgation of rules for testing
under section 4(a).... At least every six months ..., the Committee
shall make such revisions to the Priority Testing List as it
determines to be necessary and transmit them to the Administrator
together with the Committee's reasons for the revisions'' (Public
Law 94-469, 90 Stat. 2003 et seq., 15 U.S.C. 2601 et seq.). ITC
Reports are available from the ITC's web site (https://www.epa.gov/
opptintr/itc/) within a few days of submission to the Administrator
and from the EPA's web site https://www.epa.gov/fedrgstr/ after
publication in the Federal Register. The ITC produces its revisions
to the Priority Testing List with administrative and technical
support from the ITC Staff and ITC Members and their U.S. Government
organizations, and contract support provided by EPA. ITC Members and
Staff are listed at the end of this report.
II. TSCA Section 8 Reporting
A. TSCA Section 8 Reporting Rules
Following receipt of the ITC's Report (and the revised Priority
Testing List) by the EPA Administrator, the EPA's Office of
Pollution Prevention and Toxics (OPPT) may add the chemicals from
the revised Priority Testing List to the TSCA section 8(a)
Preliminary Assessment Information Reporting (PAIR) and TSCA section
8(d) Health and Safety Data Reporting (HaSDR) rules. The PAIR rule
requires producers and importers of chemicals added to the Priority
Testing List to submit production and exposure reports (https://
www.epa.gov/opptintr/chemtest/pairform.pdf/). The HaSDR rule
requires producers, importers and processors of all chemicals added
to the Priority Testing List to submit unpublished health and safety
studies under TSCA section 8(d) that must be in compliance with the
revised HaSDR rule (Ref. 1). All submissions must be received by the
EPA within 90 days of the reporting rules Federal Register
publication date.
[[Page 7367]]
B. ITC's Use of TSCA Section 8 and Other Information
The ITC's use of TSCA section 8 and other information is
described in previous ITC Reports (https://www.epa.gov/opptintr/itc/
rptmain.htm/).
C. Previous Requests to Add Chemicals to the TSCA Section 8(a) PAIR
Rule
In its 53\rd\ Report, the ITC requested that EPA add 3
pyridinamines and 20 tungsten compounds to the TSCA section 8(a)
PAIR rule (Ref. 2). On December 7, 2004, EPA issued a final rule,
pursuant to TSCA section 8(a) requiring producers and importers of
these 23 chemicals to report production, importation, and exposure
data to EPA (Ref. 3).
D. New Requests to Add Chemicals to the TSCA Section 8(a) PAIR and
8(d) HaSDR Rules
In this report, the ITC is requesting that EPA add the HPV
orphan chemicals listed in Appendix A to the TSCA section 8(a) PAIR
and 8(d) HaSDR rules. The ITC is requesting that these HPV orphan
chemicals be added to the TSCA section 8(a) PAIR and 8(d) HaSDR
rules because no voluntary studies have been submitted to the EPA in
response to the HPV Challenge Program (https://www.epa.gov/opptintr/
chemrtk/volchall.htm/).
III. ITC's Activities During this Reporting Period (May to November
2004)
During this reporting period, the ITC reviewed the reports
submitted in response to the June 11, 2003, PAIR rule (Ref. 4) and
the May 4, 2004, TSCA section 8(d) HaSDR rule (Ref. 5). The ITC is
continuing to review these reports.
The ITC also met with EPA to discuss procedures for making data
publicly available on HPV orphan chemicals (HPV chemicals for which
no sponsors have volunteered to develop and submit robust summaries
to the EPA). The ITC's discussions with EPA are described in section
IV. of this report.
As noted in the 51\st\ and 54\th\ ITC Reports (Refs. 6 and 7),
the ITC continues to request the following information on vanadium
compounds:
1. Recent non-CBI estimates of annual production or importation
volume data and trends, and use information, including percentages
of production or importation that are associated with different
uses.
2. Estimates of the number of humans and concentrations of
vanadium chemicals to which humans may be exposed in each relevant
manufacturing or processing scenario.
3. Health effects data including pharmacokinetics, genotoxicity,
subchronic toxicity, reproductive and developmental toxicity, and
any human data from occupationally exposed workers.
The ITC seeks this information in order to adequately assess the
extent and degree of exposure and potential hazard associated with
the various forms of vanadium.
In addition, the ITC is concerned that some of these compounds
may be released into fly ash ponds at power plants, petroleum and
chemical refineries, and mining sites and could be toxic to avian
and wildlife species as exemplified by a recent report of dead and
dying Canada geese at a petroleum refinery fly ash pond in Delaware.
In these geese, the vanadium concentrations in pooled liver and
kidney samples were 57 and 226 [mu]g/gram (g) dry weight,
respectively. Background concentrations of vanadium in various
tissues of higher vertebrates, including waterfowl, rarely exceed 1
[mu]g/g dry weight. Limited data are available on vanadium toxicity
in birds and other wildlife making it difficult to interpret the
findings from the geese die-off.
The ITC knows that vanadium is released into impoundments at 172
facilities in 33 states and that the TRI does not have vanadium
concentrations for these impoundments. The ITC is soliciting data on
concentrations and species of vanadium compounds in impoundments at
power plants, petroleum and chemical refineries, and mining sites
and information on the use, release, and presence of vanadium
compounds at these facilities. The ITC needs these data and
information to determine if avian wildlife in the vicinity of the
172 facilities are at risk from exposure to vanadium compounds. If
you have any questions regarding the applicability of this action to
a particular entity, consult the technical person listed under FOR
FURTHER INFORMATION CONTACT.
IV. Revisions to the TSCA Section 4(e) Priority Testing List
A. Chemicals Added to the Priority Testing List: HPV Orphan
Chemicals
1. Recommendation. EPA requests that the ITC add the category
HPV orphan chemicals listed in Appendix A of this report to the
Priority Testing List to obtain importation, production, use, and
exposure information as well as unpublished physical/chemical
property, environmental fate, health effects, and ecological effects
information to meet U.S. Government data needs.
2. Rationale for recommendation. While the success of the HPV
Challenge Program has been significant, hundreds of chemicals that
were eligible for sponsorship in the Program continue to remain
unsponsored. These chemicals are referred to as ``orphans.'' There
is little or no publicly available information regarding the
potential hazards associated with these chemicals. EPA remains
committed to obtain basic screening level hazard information on
these chemicals through voluntary sponsorship, as well as through
TSCA information gathering and test rules, as necessary.
3. Supporting information. In developing the list of HPV orphan
chemicals presented in Appendix A of this report, EPA considered all
of the HPV orphan chemicals and then removed selected HPV orphan
chemicals. The HPV orphan chemicals presented in Appendix A of this
report do not include those HPV orphan chemicals that:
a. Had 2002 Inventory Update rule reported production/
importation volumes > one million pounds (https://www.epa.gov/oppt/
iur/iur02/index.htm/ ) and were proposed for testing in the first
HPV test rule (Ref. 8).
b. Meet the ``No Longer HPV'' criteria (i.e., chemicals with
production/importation volumes < 1 million pounds based on 1998 and
2002 Inventory Update Rule data (https://www.epa.gov/oppt/iur/iur02/
index.htm/)).
c. Are being considered for a second HPV TSCA section 4 test
rule because they may meet the TSCA section 4(a)(1)(B) statutory
requirements.
At EPA's request, the ITC encourages manufacturers of these
chemicals to visit the EPA's HPV Challenge Program web site (https://
www.epa.gov/opptintr/chemrtk/volchall.htm/) and to make a commitment
to sponsor these chemicals at the present time, before regulatory
actions are initiated. EPA will initiate development of TSCA section
8(a) PAIR and 8(d) HaSDR rules soon after these chemicals are added
to the Priority Testing List and the ITC's 55\th\ Report is
published in the Federal Register. Also at EPA's request, the ITC
encourages the submission of robust summaries of studies submitted
under the TSCA section 8(d) HaSDR rule to facilitate EPA's review of
the unpublished TSCA section 8(d) studies (see USEPA. 1999. Draft
Guidance on Developing Robust Summaries. October 22, 1999 (https://
www.epa.gov/chemrtk/robsumgd.htm/)). While some of the HPV orphan
chemicals have been previously added to the TSCA section 8(d) HaSDR
rule, all of the sunset dates for these chemicals have expired (see
Appendix A of this report), thus new and so far unreported studies
would need to be submitted. Information about the environmental fate
and potential hazards associated with these chemicals when combined
with information about exposure and uses will allow the EPA and
others to evaluate and prioritize potential health and environmental
effects and determine the need for test rules under TSCA section
4(a). If you have any questions regarding the applicability of this
action to a particular entity, consult the technical person listed
under FOR FURTHER INFORMATION CONTACT.
4. Information needs. For each individual substance listed in
Appendix A of this report, EPA needs the following information to
assess the extent and degree of exposure and potential hazard
associated with these substances:
a. Production, importation, processing, use and associated
exposure information that is captured under the TSCA section 8(a)
PAIR form.
b. Unpublished studies of:
i. Physical/chemical properties and environmental fate for the
properties listed in 40 CFR 716.50 as well as melting point and
boiling point.
ii. Health effects including pharmacokinetics, genotoxicity,
acute toxicity, subacute toxicity, subchronic toxicity, chronic
toxicity, reproductive toxicity, developmental toxicity,
immunotoxicity, neurotoxicity, and oncogenicity/carcinogenicity.
iii. Ecological effects including acute and chronic toxicity
studies of aquatic and terrestrial vertebrates and invertebrates and
aquatic plants.
c. Only studies where the recommended HPV orphan chemical is >=
90% of the test substance by weight should be submitted. In
[[Page 7368]]
addition, only studies that were conducted using TSCA, Federal
Insecticide, Fungicide, and Rodenticide Act (FIFRA), Organization
for Economic Cooperation and Development (OECD), or other
internationally accepted test guidelines or voluntary consensus
standards should be submitted. Studies performed where the
recommended HPV orphan chemical is < 90% of the test substance by
weight are not requested at this time.
B. Chemicals Removed From the Priority Testing List
1. 3-Amino-5-mercapto-1,2,4-triazole. 3-Amino-5-mercapto-1,2,4-
triazole (Chemical Abstracts Service Registry Number (CAS No.)
16691-43-3 ) was added to the Priority Testing List in the ITC's
42\nd\ Report to obtain annual production/importation volumes and
trends, use, exposure, and health effects data (Ref. 9). The
addition was based on concerns that 3-amino-5-mercapto-1,2,4-
triazole was structurally related to 3-amino-1,2,4-triazole
(Amitrol[reg]), a herbicide that affects thyroid hormone activity
(Ref. 10). In response to the ITC's request, the EPA added 3-amino-
5-mercapto-1,2,4-triazole to the July 24, 2000, PAIR rule (Ref. 11)
and the May 4, 2004 HaSDR rule (Ref. 5). Numerous studies were
submitted in response to the HaSDR rule. These studies are
summarized in this unit. 3-Amino-5-mercapto-1,2,4-triazole was
positive in the mouse bone marrow micronucleus test, clastogenic to
rat lymphocytes, but not mutagenic in the Ames assay using strains
TA98, 100, 1535, and 1537 or in the E. coli assay, using strain WP2
uvrA-. 3-Amino-5-mercapto-1,2,4-triazole was a mild eye and skin
irritant, but not a skin sensitizer. In a 4-week inhalation study
the no observed effect level of 3-amino-5-mercapto-1,2,4-triazole
was 20 milligram/meter cubed (mg/m\3\).
3-Amino-5-mercapto-1,2,4-triazole is being removed from the
Priority Testing List because information submitted in response to
the PAIR rule suggested that 3-amino-5-mercapto-1,2,4-triazole is an
on-site intermediate and the production/importation volumes were
lower than the 250,000 pounds of 3-amino-5-mercapto-1,2,4-triazole
imported into the United States in 1993 (Ref. 9).
2. Glycoluril. Glycoluril (CAS No. 496-46-8) was also added to
the Priority Testing List in the ITC's 42\nd\ Report to obtain
annual production/importation volumes and trends, use, exposure, and
health effects data. The addition was based on a potential for human
exposure and a suspicion of carcinogenicity (Ref. 9). In response to
the ITC's request, the EPA added glycoluril to the July 24, 2000
PAIR rule (Ref. 11) and the May 4, 2004 HaSDR rule (Ref. 5). No
studies were submitted in response to the HaSDR rule.
Glycoluril is being removed from the Priority Testing List
because information submitted in response to the PAIR rule suggested
that glycoluril is an on-site intermediate and the production/
importation volumes were less than the 10,000 to 1,000,000 pounds of
non-CBI annual production/importation volumes reported to the EPA in
1986, 1990, and 1994 (Ref. 9).
3. Benzenamine, 3-chloro-2,6-dinitro-N,N-dipropyl-4-
(trifluoromethyl)-. Benzenamine, 3-chloro-2,6-dinitro-N,N-dipropyl-
4-(trifluoromethyl)- (aka 3-Chlorotrifluralin (CAS No. 29091-20-1)
was added to the Priority Testing List in the ITC's 48\th\ Report to
obtain information on uses, exposures, environmental releases,
pharmacokinetics, subchronic toxicity, mutagenicity, reproductive
and developmental effects, carcinogenicity, and ecological effects
(Ref. 12). Benzenamine, 3-chloro-2,6-dinitro-N,N-dipropyl-4-
(trifluoromethyl)- was added to the Priority Testing List because it
has an estimated bioconcentration factor (BCF) of 7,700 and is a
chlorinated analog of trifluralin (CAS No. 1582-09-8), the herbicide
that causes adverse effects in experimental animals and is
considered to be a possible human carcinogen by the EPA (Ref. 12).
In response to the ITC's request, the EPA added benzenamine, 3-
chloro-2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)- to the June 11,
2003 PAIR rule (Ref. 4) and the May 4, 2004 TSCA section 8(d) HaSDR
rule (Ref. 5). No information was submitted in response to the PAIR
or HaSDR rules. The ITC is removing benzenamine, 3-chloro-2,6-
dinitro-N,N-dipropyl-4-(trifluoromethyl)- from the Priority Testing
List because the PAIR rule did not provide any additional exposure
information implying that benzenamine, 3-chloro-2,6-dinitro-N,N-
dipropyl-4-(trifluoromethyl)- is not produced at greater than 1,000
pounds per site.
4. Stannane, dimethylbis[(1-oxoneodecyl)oxy]-. Stannane,
dimethylbis[(1-oxoneodecyl)oxy]- (CAS No. 68928-76-7) was added to
the Priority Testing List in the ITC's 49\th\ Report to obtain use,
exposure, environmental fate, health effects, and ecological effects
data (Ref. 13). Stannane, dimethylbis[(1-oxoneodecyl)oxy]- was added
to the Priority Testing List because it has an estimated BCF of
8,600 and signs of toxicity, including neurotoxic effects that were
observed in a rat oral gavage study (Ref. 13).
In response to the ITC's request, the EPA added stannane,
dimethylbis[(1-oxoneodecyl)oxy]- to the June 11, 2003 PAIR rule
(Ref. 4) and the May 4, 2004 TSCA section 8(d) HaSDR rule (Ref. 5).
No information was submitted in response to the HaSDR rule. The ITC
is removing stannane, dimethylbis[(1-oxoneodecyl)oxy]- from the
Priority Testing List because the information submitted in response
to the PAIR rule suggested that the production/importation volumes
of stannane, dimethylbis[(1-oxoneodecyl)oxy]- were not greater than
the 10,000-500,000 pounds of non-CBI production/importation volumes
reported to the EPA in 2002 (https://www.epa.gov/oppt/iur/iur02/
index.htm/).
5. Benzene, 1,3,5-tribromo-2-(2-propenyloxy)-. Benzene, 1,3,5-
tribromo-2-(2-propenyloxy)- (CAS No. 3278-89-5) was added to the
Priority Testing List in the ITC's 50\th\ Report to obtain use,
exposure, environmental fate, health effects, and ecological effects
data (Ref. 14). Benzene, 1,3,5-tribromo-2-(2-propenyloxy)- was added
to the Priority Testing List because of an estimated BCF of 4,000
and potential for exposure from its use as a flame retardant for
expanded polystyrene insulation board (Ref. 14).
In response to the ITC's request, the EPA added benzene, 1,3,5-
tribromo-2-(2-propenyloxy)- to the June 11, 2003 PAIR rule (Ref. 4)
and the May 4, 2004 TSCA section 8(d) HaSDR rule (Ref. 5).
Information submitted in response to the HaSDR rule indicated that
the concentrated chemical may be slightly irritating to the skin.
The ITC is removing benzene, 1,3,5-tribromo-2-(2-propenyloxy)- from
the Priority Testing List because the information submitted in
response to the PAIR rule suggested that the production/importation
volumes of benzene, 1,3,5-tribromo-2-(2-propenyloxy)- were not
greater than 10,000-500,000 pounds of non-CBI production/importation
volumes reported to the EPA in 2002 (https://www.epa.gov/oppt/iur/
iur02/index.htm/).
6. 1-Triazene, 1,3-diphenyl-. 1-Triazene, 1,3-diphenyl- (aka
diazoaminobenzene (CAS No. 136-35-6) was added to the Priority
Testing List in the ITC's 50\th\ Report to obtain annual production/
importation volumes and trends, use, exposure, and health effects
data (Ref. 14). 1-Triazene, 1,3-diphenyl- was added to the Priority
Testing List because it is a predicted carcinogen based on its
metabolism and similarity in toxic effects to benzene and aniline
(Ref. 14).
In response to the ITC's request, the EPA added 1-triazene, 1,3-
diphenyl- to the June 11, 2003 PAIR rule (Ref. 4) and the May 4,
2004 TSCA section 8(d) HaSDR rule (Ref. 5). No information was
submitted in response to the PAIR or HaSDR rules. The ITC is
removing 1-triazene, 1,3-diphenyl- from the Priority Testing List
because the PAIR rule did not provide any additional exposure
information implying that 1-triazene, 1,3-diphenyl- is not produced
at greater than 1,000 pounds per site.
V. References
1. EPA. 1998. Revisions to Reporting Regulations Under TSCA
Section 8(d). Direct Final Rule. Federal Register (63 FR 15765,
April 1, 1998) (FRL-5750-4). Available online at: https://
www.epa.gov/fedrgstr/.
2. ITC. 2004. Fifty-Third Report of the ITC. Federal Register
(69 FR 2467, January 15, 2004) (FRL-7335-2). Available online at:
https://www.epa.gov/fedrgstr/.
3. EPA. 2004. Preliminary Assessment Information Reporting;
Addition of Certain Chemicals. Final Rule. Federal Register (69 FR
70552, December 7, 2004) (FRL-7366-8). Available online at: https://
www.epa.gov/fedrgstr/.
4. EPA. 2003. Preliminary Assessment Information Reporting;
Addition of Certain Chemicals. Final Rule. Federal Register (68 FR
34832, June 11, 2003) (FRL-7306-7). Available online at: https://
www.epa.gov/fedrgstr/.
5. EPA. 2004. Health and Safety Data Reporting; Addition of
Certain Chemicals. Final Rule. Federal Register (69 FR 24517, May 4,
2004) (FRL-7322-8). Available online at: https://www.epa.gov/
fedrgstr/.
6. ITC. 2003. Fifty-First Report of the ITC. Federal Register
(68 FR 8976, February 26, 2003) (FRL-7285-7). Available online at:
https://www.epa.gov/fedrgstr/.
7. ITC. 2004. Fifty-Fourth Report of the ITC. Federal Register
(69 FR 33527, June 15, 2004) (FRL-7359-6). Available online at:
https://www.epa.gov/fedrgstr/.
8. EPA. 2000. Testing of Certain High Production Volume
Chemicals. Proposed
[[Page 7369]]
Rule. Federal Register (65 FR 81658, December 26, 2000) (FRL-6758-
4). Available online at: https://www.epa.gov/fedrgstr/.
9. ITC. 1998. Forty-Second Report of the ITC. Federal Register
(63 FR 42554, August 7, 1998) (FRL-5797-8). Available online at:
https://www.epa.gov/fedrgstr/.
10. Takaoka, M., M. Teranishi, and S. Manabe. 1994. Structure-
Activity Relationships in 5-Substituted 3-Amino-1,2,4-Triazoles-
Induced Goiters in Rats. Journal of Toxicology and Pathology. 7:429-
434.
11. EPA. 2000. Preliminary Assessment Information Reporting;
Addition of Certain Chemicals. Final Rule. Federal Register (65 FR
45535, July 24, 2000) (FRL-6597-3). Available online at: https://
www.epa.gov/fedrgstr/.
12. ITC. 2001. Forty-Eighth Report of the ITC. Federal Register
(66 FR 51276, October 5, 2001) (FRL-6786-7). Available online at:
https://www.epa.gov/fedrgstr/.
13. ITC. 2002. Forty-Ninth Report of the ITC. Federal Register
(67 FR 10298, March 6, 2002) (FRL-6820-8). Available online at:
https://www.epa.gov/fedrgstr/.
14. ITC. 2002. Fiftieth Report of the ITC. Federal Register (67
FR 49530, July 30, 2002) (FRL-7183-7). Available online at: https://
www.epa.gov/fedrgstr/.
VI. The TSCA Interagency Testing Committee
Statutory Organizations and Their Representatives
Council on Environmental Quality
Vacant
Department of Commerce
National Institute of Standards and Technology
Dianne Poster, Member
Peter Barker, Alternate
National Oceanographic and AtmosphericAdministration
Thomas P. O'Connor, Member, Chair
Teri Rowles, Alternate
Environmental Protection Agency
Gerry Brown, Member
Paul Campanella, Alternate
National Cancer Institute
Alan Poland, Member
Shen Yang, Alternate
National Institute of Environmental Health Sciences
Barbara Shane, Member
Scott Masten, Alternate
National Institute for Occupational Safety and Health
Mark Toraason, Member
Dennis W. Lynch, Alternate
National Science Foundation
Marge Cavanaugh, Member
Parag R. Chitnis, Alternate
Occupational Safety and Health Administration
Maureen Ruskin, Member
Liaison Organizations and Their Representatives
Agency for Toxic Substances and Disease Registry
Daphne Moffett, Member
Consumer Product Safety Commission
Treye Thomas, Member
Jacqueline Ferrante, Alternate
Department of Agriculture
Clifford P. Rice, Member, Vice Chair
Laura L. McConnell, Alternate
Department of Defense
Warren Jederberg, Member
Department of the Interior
Barnett A. Rattner, Member
Food and Drug Administration
Kirk Arvidson, Alternate
Ronald F. Chanderbhan, Alternate
National Library of Medicine
Vera W. Hudson, Member
National Toxicology Program
NIEHS, FDA, and NIOSH Members
Technical Support Contractor
Syracuse Research Corporation
ITC Staff
John D. Walker, Director
Norma S. L. Williams, Executive Assistant
TSCA Interagency Testing Committee (7401), Office of Pollution
Prevention and Toxics, Environmental Protection Agency, 1200
Pennsylvania Ave., NW., Washington, DC 20460-0001; e-mail address:
walker.johnd@epa.gov; url: https://www.epa.gov/ opptintr/itc/.
Appendix A--Chemical Abstracts Service Registry Number (CAS No.), TSCA Inventory Names and Previous TSCA Section
8(d) Rule Sunset Dates of HPV Orphan Chemicals for Which the ITC is Requesting that the EPA Add to TSCA Section
8(a) and 8(d) Rules
----------------------------------------------------------------------------------------------------------------
Previous TSCA section 8(d) rule
CAS No. TSCA Inventory Name sunset date
----------------------------------------------------------------------------------------------------------------
62-56-6 Thiourea ..................................
------------------------------------------------------------------------------
74-97-5 Methane, bromochloro- 6/1/1997
------------------------------------------------------------------------------
75-34-3 Ethane, 1,1-dichloro- 6/1/1997
------------------------------------------------------------------------------
75-46-7 Methane, trifluoro- ..................................
------------------------------------------------------------------------------
77-76-9 Propane, 2,2-dimethoxy- ..................................
------------------------------------------------------------------------------
81-07-2 1,2-Benzisothiazol-3(2H)-one, 1,1- ..................................
dioxide
------------------------------------------------------------------------------
81-16-3 1-Naphthalenesulfonic acid, 2-amino- ..................................
------------------------------------------------------------------------------
81-84-5 1H,3H-Naphtho[1,8-cd]pyran-1,3-dione 6/30/1998
------------------------------------------------------------------------------
83-41-0 Benzene, 1,2-dimethyl-3-nitro- ..................................
------------------------------------------------------------------------------
84-69-5 1,2-Benzenedicarboxylic acid, bis(2- 10/4/1992
methylpropyl) ester
------------------------------------------------------------------------------
85-40-5 1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a- ..................................
tetrahydro-
------------------------------------------------------------------------------
90-43-7 [1,1'-Biphenyl]-2-ol ..................................
------------------------------------------------------------------------------
91-68-9 Phenol, 3-(diethylamino)- ..................................
------------------------------------------------------------------------------
94-75-7 Acetic acid, (2,4-dichlorophenoxy)- ..................................
------------------------------------------------------------------------------
[[Page 7370]]
94-96-2 1,3-Hexanediol, 2-ethyl- ..................................
------------------------------------------------------------------------------
95-94-3 Benzene, 1,2,4,5-tetrachloro- 10/4/1992
------------------------------------------------------------------------------
96-22-0 3-Pentanone ..................................
------------------------------------------------------------------------------
96-23-1 2-Propanol, 1,3-dichloro- ..................................
------------------------------------------------------------------------------
97-00-7 Benzene, 1-chloro-2,4-dinitro- ..................................
------------------------------------------------------------------------------
98-09-9 Benzenesulfonyl chloride ..................................
------------------------------------------------------------------------------
98-16-8 Benzenamine, 3-(trifluoromethyl)- ..................................
------------------------------------------------------------------------------
98-56-6 Benzene, 1-chloro-4-(trifluoromethyl)- 4/29/1993
------------------------------------------------------------------------------
99-51-4 Benzene, 1,2-dimethyl-4-nitro- ..................................
------------------------------------------------------------------------------
100-64-1 Cyclohexanone, oxime ..................................
------------------------------------------------------------------------------
101-34-8 9-Octadecenoic acid, 12-(acetyloxy)-, ..................................
1,2,3-propanetriyl ester,
(9Z,9'Z,9''Z,12R,12'R,12''R)-
------------------------------------------------------------------------------
104-66-5 Benzene, 1,1'-[1,2- ..................................
ethanediylbis(oxy)]bis-
------------------------------------------------------------------------------
104-93-8 Benzene, 1-methoxy-4-methyl- ..................................
------------------------------------------------------------------------------
107-39-1 1-Pentene, 2,4,4-trimethyl- ..................................
------------------------------------------------------------------------------
107-40-4 2-Pentene, 2,4,4-trimethyl- ..................................
------------------------------------------------------------------------------
107-45-9 2-Pentanamine, 2,4,4-trimethyl- ..................................
------------------------------------------------------------------------------
110-18-9 1,2-Ethanediamine, N,N,N',N'-tetramethyl- ..................................
------------------------------------------------------------------------------
110-33-8 Hexanedioic acid, dihexyl ester ..................................
------------------------------------------------------------------------------
111-44-4 Ethane, 1,1'-oxybis[2-chloro- ..................................
------------------------------------------------------------------------------
111-85-3 Octane, 1-chloro- ..................................
------------------------------------------------------------------------------
111-91-1 Ethane, 1,1'-[methylenebis(oxy)]bis[2- ..................................
chloro-
------------------------------------------------------------------------------
118-90-1 Benzoic acid, 2-methyl- ..................................
------------------------------------------------------------------------------
119-33-5 Phenol, 4-methyl-2-nitro- 6/30/1998
------------------------------------------------------------------------------
121-69-7 Benzenamine, N,N-dimethyl- 6/30/1998
------------------------------------------------------------------------------
121-82-4 1,3,5-Triazine, hexahydro-1,3,5-trinitro- ..................................
------------------------------------------------------------------------------
124-63-0 Methanesulfonyl chloride ..................................
------------------------------------------------------------------------------
127-68-4 Benzenesulfonic acid, 3-nitro-, sodium ..................................
salt
------------------------------------------------------------------------------
131-57-7 Methanone, (2-hydroxy-4- ..................................
methoxyphenyl)phenyl-
------------------------------------------------------------------------------
137-20-2 Ethanesulfonic acid, 2-[methyl[(9Z)-1- 12/28/1994
oxo-9- octadecenyl]amino]-, sodium salt
------------------------------------------------------------------------------
138-25-0 1,3-Benzenedicarboxylic acid, 5-sulfo-, ..................................
1,3-dimethyl ester
------------------------------------------------------------------------------
139-40-2 1,3,5-Triazine-2,4-diamine, 6-chloro- ..................................
N,N'-bis(1-methylethyl)-
------------------------------------------------------------------------------
140-08-9 Ethanol, 2-chloro-, phosphite (3:1) ..................................
------------------------------------------------------------------------------
140-93-2 Carbonodithioic acid, O-(1-methylethyl) ..................................
ester, sodium salt
------------------------------------------------------------------------------
142-73-4 Glycine, N-(carboxymethyl)- ..................................
------------------------------------------------------------------------------
[[Page 7371]]
150-50-5 Phosphorotrithious acid, tributyl ester ..................................
------------------------------------------------------------------------------
307-35-7 1-Octanesulfonyl fluoride, ..................................
1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-
heptadecafluoro-
------------------------------------------------------------------------------
330-54-1 Urea, N'-(3,4-dichlorophenyl)-N,N- ..................................
dimethyl-
------------------------------------------------------------------------------
460-00-4 Benzene, 1-bromo-4-fluoro- ..................................
------------------------------------------------------------------------------
506-51-4 1-Tetracosanol ..................................
------------------------------------------------------------------------------
506-52-5 1-Hexacosanol ..................................
------------------------------------------------------------------------------
513-74-6 Carbamodithioic acid, monoammonium salt ..................................
------------------------------------------------------------------------------
515-40-2 Benzene, (2-chloro-1,1-dimethylethyl)- ..................................
------------------------------------------------------------------------------
529-33-9 1-Naphthalenol, 1,2,3,4-tetrahydro- ..................................
------------------------------------------------------------------------------
529-34-0 1(2H)-Naphthalenone, 3,4-dihydro- ..................................
------------------------------------------------------------------------------
542-75-6 1-Propene, 1,3-dichloro- ..................................
------------------------------------------------------------------------------
542-92-7 1,3-Cyclopentadiene 6/30/1998
------------------------------------------------------------------------------
557-61-9 1-Octacosanol ..................................
------------------------------------------------------------------------------
563-72-4 Ethanedioic acid, calcium salt (1:1) ..................................
------------------------------------------------------------------------------
579-66-8 Benzenamine, 2,6-diethyl- ..................................
------------------------------------------------------------------------------
590-19-2 1,2-Butadiene ..................................
------------------------------------------------------------------------------
592-45-0 1,4-Hexadiene ..................................
------------------------------------------------------------------------------
597-31-9 Propanal, 3-hydroxy-2,2-dimethyl- 6/30/1998
------------------------------------------------------------------------------
598-72-1 Propanoic acid, 2-bromo- ..................................
------------------------------------------------------------------------------
617-94-7 Benzenemethanol, .alpha.,.alpha.- ..................................
dimethyl-
------------------------------------------------------------------------------
625-55-8 Formic acid, 1-methylethyl ester ..................................
------------------------------------------------------------------------------
628-13-7 Pyridine, hydrochloride ..................................
------------------------------------------------------------------------------
628-96-6 1,2-Ethanediol, dinitrate ..................................
------------------------------------------------------------------------------
645-62-5 2-Hexenal, 2-ethyl- ..................................
------------------------------------------------------------------------------
693-07-2 Ethane, 1-chloro-2-(ethylthio)- ..................................
------------------------------------------------------------------------------
693-95-8 Thiazole, 4-methyl- ..................................
------------------------------------------------------------------------------
756-80-9 Phosphorodithioic acid, O,O-dimethyl ..................................
ester
------------------------------------------------------------------------------
870-72-4 Methanesulfonic acid, hydroxy-, ..................................
monosodium salt
------------------------------------------------------------------------------
928-72-3 Glycine, N-(carboxymethyl)-, disodium ..................................
salt
------------------------------------------------------------------------------
939-97-9 Benzaldehyde, 4-(1,1-dimethylethyl)- 11/9/1993
------------------------------------------------------------------------------
1000-82-4 Urea, (hydroxymethyl)- 7/1/1993
------------------------------------------------------------------------------
1002-69-3 Decane, 1-chloro- ..................................
------------------------------------------------------------------------------
1111-78-0 Carbamic acid, monoammonium salt ..................................
------------------------------------------------------------------------------
1115-20-4 Propanoic acid, 3-hydroxy-2,2-dimethyl-, ..................................
3-hydroxy-2,2-dimethylpropyl ester
------------------------------------------------------------------------------
1401-55-4 Tannins ..................................
------------------------------------------------------------------------------
[[Page 7372]]
1445-45-0 Ethane, 1,1,1-trimethoxy- ..................................
------------------------------------------------------------------------------
1459-93-4 1,3-Benzenedicarboxylic acid, dimethyl ..................................
ester
------------------------------------------------------------------------------
1498-51-7 Phosphorodichloridic acid, ethyl ester 11/9/1993
------------------------------------------------------------------------------
1558-33-4 Silane, dichloro(chloromethyl)methyl- ..................................
------------------------------------------------------------------------------
1646-75-9 Propanal, 2-methyl-2-(methylthio)-, ..................................
oxime
------------------------------------------------------------------------------
1691-99-2 1-Octanesulfonamide, N-ethyl- ..................................
1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-
heptadecafluoro-N-(2-hydroxyethyl)-
------------------------------------------------------------------------------
1738-25-6 Propanenitrile, 3-(dimethylamino)- ..................................
------------------------------------------------------------------------------
1912-24-9 1,3,5-Triazine-2,4-diamine, 6-chloro-N- ..................................
ethyl-N'-(1-methylethyl)-
------------------------------------------------------------------------------
1918-02-1 2-Pyridinecarboxylic acid, 4-amino-3,5,6- ..................................
trichloro-
------------------------------------------------------------------------------
1929-82-4 Pyridine, 2-chloro-6-(trichloromethyl)- ..................................
------------------------------------------------------------------------------
2152-64-9 Benzenamine, N-phenyl-4-[[4- ..................................
(phenylamino)phenyl][4-(phenylimino)-
2,5-cyclohexadien-1-ylidene]methyl]-,
monohydrochloride
------------------------------------------------------------------------------
2210-79-9 Oxirane, [(2-methylphenoxy)methyl]- 10/4/1992
------------------------------------------------------------------------------
2372-45-4 1-Butanol, sodium salt ..................................
-----------------------------------------------------
