The National Toxicology Program (NTP) Announces the Availability of the Report on Carcinogens, Eleventh Edition, 6721-6723 [05-2393]
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Federal Register / Vol. 70, No. 25 / Tuesday, February 8, 2005 / Notices
Date: February 23, 2005.
Time: 1 p.m. to 6 p.m.
Agenda: To review and evaluate grant
applications.
Place: Bethesda North Marriott Hotel,
11200 Rockville Pike, Rockville, MD 20852.
Contact Person: Karin F. Helmers, PhD,
Scientific Review Administrator, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3166,
MSC 7770, Bethesda, MD 20892, 301–435–
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Date: February 25, 2005.
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Institutes of Health, HHS).
Dated: February 3, 2005.
LaVerne Y. Stringfield,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 05–2405 Filed 2–7–05; 8:45 am]
BILLING CODE 4140–01–M
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Public Health Service
The National Toxicology Program
(NTP) Announces the Availability of
the Report on Carcinogens, Eleventh
Edition
The Department of Health and Human
Services released the Report on
Carcinogens, Eleventh Edition to the
public on January 31, 2005. The report
is available free-of-charge on the
Internet from the NTP Web site at: http:/
/ntp.niehs.nih.gov. Printed copies of the
Report on Carcinogens, Eleventh Edition
can be obtained by contacting: Central
Data Management (CDM), MD–EC–03,
National Institute of Environmental
Health Sciences, P.O. Box 12233, 79
T.W. Alexander Dr., Building 4401,
Suite 100, Research Triangle Park, NC
27709 USA; 919–541–3419 (phone),
919–541–3687 (fax), e-mail:
cdm@niehs.nih.gov.
Background
The Report on Carcinogens (RoC)
(previously known as the Annual Report
on Carcinogens) is a Congressionally
mandated listing of known human
carcinogens and reasonably anticipated
human carcinogens whose preparation
is delegated to the NTP by the Secretary,
Department of Health and Human
Services (DHHS). Section 301(b)(4) of
the Public Health Service Act, as
amended, provides that the Secretary,
DHHS, shall publish a biennial report
which contains a list of all substances
(1) which either are known to be human
carcinogens or may reasonably be
anticipated to be human carcinogens;
and (2) to which a significant number of
persons residing in the United States are
exposed. The law also states that the
reports should provide available
information on the nature of exposures,
the estimated number of persons
exposed, and the extent to which the
implementation of federal regulations
decreases the risk to public health from
exposure to these chemicals.
The RoC is an informational,
scientific, and public health document
that identifies and discusses agents,
substances, mixtures, or exposure
circumstances that may pose a
carcinogenic hazard to human health. It
serves as a meaningful and useful
compilation of data on the (1)
carcinogenicity, genotoxicity, and
biologic mechanisms of the listed
substances in humans and/or animals,
(2) the potential for exposure to these
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6721
substances, and (3) the regulations
promulgated by Federal agencies to
limit exposures. The report does not
present quantitative assessments of
carcinogenic risk, an assessment that
defines the conditions under which the
hazard may be unacceptable. Listing of
substances in the report, therefore, does
not establish that such substances
present carcinogenic risks to individuals
in their daily lives. Such formal risk
assessments are the purview of the
appropriate federal, state, and local
health regulatory and research agencies.
New Listings to the RoC, Eleventh
Edition
The RoC, Eleventh Edition, contains
246 entries, 17 of which have not
appeared in earlier RoCs. The table
below summarizes the actions taken for
the substances or exposure
circumstances reviewed for possible
listing in the RoC, Eleventh Edition.
The review of the new entries to the
RoC, Eleventh Edition followed a formal
process that included many phases of
scientific peer review and multiple
opportunities for public comment. The
process included three scientific peer
reviews: two separate, internal reviews
conducted by scientists within the
federal government and an external
review in a public forum conducted by
both non-government and government
scientists. The three scientific review
committees evaluated all available data
relevant to the criteria for inclusion of
candidate nominations in the report.
The criteria used to evaluate the
nominations and a description of the
review procedures used are available on
the NTP Web site at https://
ntp.niehs.nih.gov/ or by contacting: Dr.
C. W. Jameson, Head—Report on
Carcinogens, National Toxicology
Program, National Institute of
Environmental Health Sciences, MD
EC–14, P.O. Box 12233, Research
Triangle Park, NC 27709; phone: (919)
541–4096, fax: (919) 541–0144, e-mail:
jameson@niehs.nih.gov.
Questions or comments concerning
the RoC, Eleventh Edition should be
directed to: Dr. Mary Wolfe, NTP
Liaison and Scientific Review Office,
National Institute of Environmental
Health Sciences, MD–A3, P.O. Box
12233, Research Triangle Park, NC
27709; phone: (919) 541–0530, fax: (919)
541–0295, e-mail: wolfe@niehs.nih.gov.
Dated: January 31, 2005.
Kenneth Olden,
Director, National Toxicology Program.
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Federal Register / Vol. 70, No. 25 / Tuesday, February 8, 2005 / Notices
SUMMARY OF ACTIONS FOR AGENTS, SUBSTANCES, MIXTURES OR EXPOSURE CIRCUMSTANCES REVIEWED FOR LISTING IN
THE ELEVENTH EDITION OF THE REPORT ON CARCINOGENS
Nominations
Primary uses or exposures
Action
1–Amino-2,4-dibromoanthraquinone ..................
An anthraquinone-derived vat dye that is used
in the textile industry.
Used in electroplating and electrochemical industries. It is also used as a coloring agent
for ceramics and as a drying agent in inks,
paints, varnishes and linoleum, and has
been added to animal feed as a mineral
supplement.
Used as an intermediate in the production of
dyes and to promote adhesion of natural
rubber to steel.
Used in the preparation of surfactants used in
liquid laundry, dishwashing detergents, cosmetics, shampoos, and hair conditioners; as
a surface-active agent and corrosion inhibitor in metalworking fluids; and as a dispersant in agricultural chemical formulations.
A small DNA-enveloped virus that, along with
Hepatitis C Virus, causes most parenterally
transmitted viral hepatitis.
An RNA-enveloped virus that, along with Hepatitis B Virus, causes most parenterally
transmitted viral hepatitis.
Heterocyclic amines that are formed during
grilling or cooking at high temperature and
are found in cooked meat and fish.
Listed as reasonably anticipated to be a
human carcinogen.
Listed as reasonably anticipated to be a
human carcinogen.
Small, non-enveloped viruses that infect genital skin, and genital and non-genital mucosa. HPV infections are common throughout the world.
Major use is in making lead-acid storage batteries. Other common uses include ammunition and cable covering. Lead compounds
are used in paint, glass, ceramics, fuel additives, and some traditional cosmetics.
Used as an intermediate in the synthesis of
many industrial chemicals, and has been
used as an ingredient in some moth
repellants and toilet bowl deodorants.
Exposures normally occur from a mixed irradiation field in which neutrons are a minor
component. The exceptions are exposure of
patients to neutron radiotherapy beams and
exposures of aircraft passengers and crew.
Used mainly in the production of aniline, itself
a major chemical intermediate in the production of dyes.
Used in specialized fuels, in explosives, and
in the synthesis of nitromethane derivatives,
pharmaceuticals, agricultural soil fumigants,
and industrial antimicrobials.
Used as an intermediate of several diazo
dyes.
Exposure to these forms of ionizing radiation
comes from a variety of natural (environmental exposure) and anthropogenic
sources, including exposure for military,
medical, and occupational purposes.
Listed as known to be human carcinogens.
Cobalt Sulfate .....................................................
Diazoaminobenzene ...........................................
Diethanolamine ...................................................
Hepatitis B Virus .................................................
Hepatitis C Virus ................................................
Selected Heterocyclic Amines (three):
(1)
2-Amino-3,4-dimethylimidazo[4,5f]quinoline (MeIQ)
(2)
2-Amino-3,8-dimethylimidazo[4,5f]quinoxaline (MeIQx)
(3) 2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP)
Human Papillomaviruses, Some GenitalMucosal Types.
Lead and Lead Compounds ...............................
Naphthalene .......................................................
Neutrons .............................................................
Nitrobenzene ......................................................
Nitromethane ......................................................
4,4’-Thiodianiline ................................................
X–Radiation and Gamma (g)-Radiation .............
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Listed as reasonably anticipated to be a
human carcinogen.
Not listed.
Listed as known to be a human carcinogen.
Listed as known to be a human carcinogen.
Listed as reasonably anticipated to be human
carcinogens.
Listed as reasonably anticipated to be human
carcinogens.
Listed as reasonably anticipated to be a
human carcinogen.
Listed as known to be human carcinogens.
Listed as reasonably anticipated to be a
human carcinogen.
Listed as reasonably anticipated to be a
human carcinogen.
Listed as reasonably anticipated to be a
human carcinogen.
Listed as known to be human carcinogens.
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Federal Register / Vol. 70, No. 25 / Tuesday, February 8, 2005 / Notices
[FR Doc. 05–2393 Filed 2–7–05; 8:45 am]
BILLING CODE 4140–01–U
DEPARTMENT OF HOMELAND
SECURITY
Coast Guard
[USCG–2004–18949]
Collection of Information Under
Review by Office of Management and
Budget (OMB): 1625–0006 (Formerly
2115–0015), Shipping Articles
Coast Guard, DHS.
Request for comments.
AGENCY:
ACTION:
SUMMARY: In compliance with the
Paperwork Reduction Act of 1995, this
request for comments announces that
the Coast Guard has forwarded one
Information Collection Report (ICR)—
1625–0006, Shipping Articles—
abstracted below, to the Office of
Information and Regulatory Affairs
(OIRA) of the Office of Management and
Budget (OMB) for review and comment.
Our ICR describes the information we
seek to collect from the public. Review
and comment by OIRA ensures that we
impose only paperwork burdens
commensurate with our performance of
duties.
DATES: Please submit your comments on
or before March 10, 2005.
ADDRESSES: To make sure that your
comments and related material do not
reach the docket [USCG–2004–18949] or
OIRA more than once, please submit
them by only one of the following
means:
(1)(a) By mail to the Docket
Management Facility, U.S. Department
of Transportation (DOT), room PL–401,
400 Seventh Street SW., Washington,
DC 20590–0001. (b) By mail to OIRA,
725 17th St., NW., Washington, DC
20503, to the attention of the Desk
Officer for the Coast Guard.
(2)(a) By delivery to room PL–401 at
the address given in paragraph (1)(a)
above, between 9 a.m. and 5 p.m.,
Monday through Friday, except Federal
holidays. The telephone number is (202)
366–9329. (b) By delivery to OIRA, at
the address given in paragraph (1)(b)
above, to the attention of the Desk
Officer for the Coast Guard.
(3) By fax to (a) the Facility at (202)
493–2298 and (b) OIRA at (202) 395–
6566, or e-mail to OIRA at oiradocket@omb.eop.gov attention: Desk
Officer for the Coast Guard.
(4)(a) Electronically through the Web
Site for the Docket Management System
at https://dms.dot.gov. (b) OIRA does not
have a Web site on which you can post
your comments.
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The Docket Management Facility
maintains the public docket for this
notice. Comments and material received
from the public, as well as documents
mentioned in this notice as being
available in the docket, will become part
of this docket and will be available for
inspection or copying at room PL–401
on the Plaza level of the Nassif Building,
400 Seventh Street, SW., Washington,
DC, between 9 a.m. and 5 p.m., Monday
through Friday, except Federal holidays.
You may also find this docket on the
Internet at https://dms.dot.gov.
Copies of the complete ICR are
available through this docket on the
Internet at https://dms.dot.gov, and also
from Commandant (CG–611), U.S. Coast
Guard Headquarters, room 6106 (Attn:
Ms. Barbara Davis), 2100 Second Street,
SW., Washington, DC 20593–0001. The
telephone number is (202) 267–2326.
Ms.
Barbara Davis, Office of Information
Management, telephone (202) 267–2326
or fax (202) 267–4814, for questions on
these documents; or Ms. Andrea M.
Jenkins, Program Manager, Docket
Operations, (202) 366–0271, for
questions on the docket.
FOR FURTHER INFORMATION CONTACT:
The Coast
Guard invites comments on the
proposed collection of information to
determine whether the collections are
necessary for the proper performance of
the functions of the Department. In
particular, the Coast Guard would
appreciate comments addressing: (1)
The practical utility of the collections;
(2) the accuracy of the estimated burden
of the collections; (3) ways to enhance
the quality, utility, and clarity of the
information that is the subject of the
collections; and (4) ways to minimize
the burden of collections on
respondents, including the use of
automated collection techniques or
other forms of information technology.
Comments to DMS or OIRA must
contain the OMB Control Number of the
Information Collection Reports (ICR)
addressed. Comments to DMS must
contain the docket number of this
request, [USCG 2004–18949]. Comments
to OIRA are best assured of having their
full effect if OIRA receives them on or
before March 10, 2005.
Public participation and request for
comments: We encourage you to
participate in this request for comments
by submitting comments and related
materials. We will post all comments
received, without change, to https://
dms.dot.gov, and they will include any
personal information you have
provided. We have an agreement with
DOT to use their Docket Management
SUPPLEMENTARY INFORMATION:
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Facility. Please see the paragraph on
DOT’s ‘‘Privacy Act Policy’’ below.
Submitting comments: If you submit a
comment, please include your name and
address, identify the docket number for
this request for comment [USCG–2004–
18949], indicate the specific section of
this document or the ICR to which each
comment applies, and give the reason
for each comment. You may submit
your comments and material by
electronic means, mail, fax, or delivery
to the Docket Management Facility at
the address under ADDRESSES, but
please submit them by only one means.
If you submit them by mail or delivery,
submit them in an unbound format, no
larger than 81⁄2 by 11 inches, suitable for
copying and electronic filing. If you
submit them by mail and would like to
know that they reached the Facility,
please enclose a stamped, self-addressed
postcard or envelope.
We will consider all comments and
material received during the comment
period. We may change the documents
supporting this collection of
information or even the underlying
requirements in view of them.
Viewing comments and documents:
To view comments, as well as
documents mentioned in this notice as
being available in the docket, go to
https://dms.dot.gov at any time and
conduct a simple search using the
docket number. You may also visit the
Docket Management Facility in room
PL–401 on the Plaza level of the Nassif
Building, 400 Seventh Street, SW.,
Washington, DC, between 9 a.m. and 5
p.m., Monday through Friday, except
Federal holidays.
Privacy Act: Anyone can search the
electronic form of all comments
received in dockets by the name of the
individual submitting the comment (or
signing the comment, if submitted on
behalf of an association, business, labor
union, etc.). You may review the
Privacy Act Statement of DOT in the
Federal Register published on April 11,
2000 (65 FR 19477), or you may visit
https://dms.dot.gov.
Previous Request for Comments
This request provides a 30-day
comment period required by OIRA. The
Coast Guard has already published the
60-day notice required by 44 U.S.C.
3506(c)(2) (69 FR 54301, September 8,
2004). That notice elicited one
comment. The commenter noted that
form CG–705A—Shipping Articles,
should be revised, including an altering
of the layout to a more standard size,
utilizing IT (i.e. online) if possible. The
Coast Guard agrees that form CG–705A
is long overdue for updating and
redesign. The Coast Guard will,
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]]>Agencies
[Federal Register Volume 70, Number 25 (Tuesday, February 8, 2005)]
[Notices]
[Pages 6721-6723]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 05-2393]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
The National Toxicology Program (NTP) Announces the Availability
of the Report on Carcinogens, Eleventh Edition
The Department of Health and Human Services released the Report on
Carcinogens, Eleventh Edition to the public on January 31, 2005. The
report is available free-of-charge on the Internet from the NTP Web
site at: https://ntp.niehs.nih.gov. Printed copies of the Report on
Carcinogens, Eleventh Edition can be obtained by contacting: Central
Data Management (CDM), MD-EC-03, National Institute of Environmental
Health Sciences, P.O. Box 12233, 79 T.W. Alexander Dr., Building 4401,
Suite 100, Research Triangle Park, NC 27709 USA; 919-541-3419 (phone),
919-541-3687 (fax), e-mail: cdm@niehs.nih.gov.
Background
The Report on Carcinogens (RoC) (previously known as the Annual
Report on Carcinogens) is a Congressionally mandated listing of known
human carcinogens and reasonably anticipated human carcinogens whose
preparation is delegated to the NTP by the Secretary, Department of
Health and Human Services (DHHS). Section 301(b)(4) of the Public
Health Service Act, as amended, provides that the Secretary, DHHS,
shall publish a biennial report which contains a list of all substances
(1) which either are known to be human carcinogens or may reasonably be
anticipated to be human carcinogens; and (2) to which a significant
number of persons residing in the United States are exposed. The law
also states that the reports should provide available information on
the nature of exposures, the estimated number of persons exposed, and
the extent to which the implementation of federal regulations decreases
the risk to public health from exposure to these chemicals.
The RoC is an informational, scientific, and public health document
that identifies and discusses agents, substances, mixtures, or exposure
circumstances that may pose a carcinogenic hazard to human health. It
serves as a meaningful and useful compilation of data on the (1)
carcinogenicity, genotoxicity, and biologic mechanisms of the listed
substances in humans and/or animals, (2) the potential for exposure to
these substances, and (3) the regulations promulgated by Federal
agencies to limit exposures. The report does not present quantitative
assessments of carcinogenic risk, an assessment that defines the
conditions under which the hazard may be unacceptable. Listing of
substances in the report, therefore, does not establish that such
substances present carcinogenic risks to individuals in their daily
lives. Such formal risk assessments are the purview of the appropriate
federal, state, and local health regulatory and research agencies.
New Listings to the RoC, Eleventh Edition
The RoC, Eleventh Edition, contains 246 entries, 17 of which have
not appeared in earlier RoCs. The table below summarizes the actions
taken for the substances or exposure circumstances reviewed for
possible listing in the RoC, Eleventh Edition.
The review of the new entries to the RoC, Eleventh Edition followed
a formal process that included many phases of scientific peer review
and multiple opportunities for public comment. The process included
three scientific peer reviews: two separate, internal reviews conducted
by scientists within the federal government and an external review in a
public forum conducted by both non-government and government
scientists. The three scientific review committees evaluated all
available data relevant to the criteria for inclusion of candidate
nominations in the report. The criteria used to evaluate the
nominations and a description of the review procedures used are
available on the NTP Web site at https://ntp.niehs.nih.gov/ or by
contacting: Dr. C. W. Jameson, Head--Report on Carcinogens, National
Toxicology Program, National Institute of Environmental Health
Sciences, MD EC-14, P.O. Box 12233, Research Triangle Park, NC 27709;
phone: (919) 541-4096, fax: (919) 541-0144, e-mail:
jameson@niehs.nih.gov.
Questions or comments concerning the RoC, Eleventh Edition should
be directed to: Dr. Mary Wolfe, NTP Liaison and Scientific Review
Office, National Institute of Environmental Health Sciences, MD-A3,
P.O. Box 12233, Research Triangle Park, NC 27709; phone: (919) 541-
0530, fax: (919) 541-0295, e-mail: wolfe@niehs.nih.gov.
Dated: January 31, 2005.
Kenneth Olden,
Director, National Toxicology Program.
[[Page 6722]]
Summary of Actions for Agents, Substances, Mixtures or Exposure
Circumstances Reviewed for Listing in the Eleventh Edition of the Report
on Carcinogens
------------------------------------------------------------------------
Primary uses or
Nominations exposures Action
------------------------------------------------------------------------
1-Amino-2,4- An anthraquinone- Listed as reasonably
dibromoanthraquinone. derived vat dye anticipated to be a
that is used in the human carcinogen.
textile industry.
Cobalt Sulfate.............. Used in Listed as reasonably
electroplating and anticipated to be a
electrochemical human carcinogen.
industries. It is
also used as a
coloring agent for
ceramics and as a
drying agent in
inks, paints,
varnishes and
linoleum, and has
been added to
animal feed as a
mineral supplement.
Diazoaminobenzene........... Used as an Listed as reasonably
intermediate in the anticipated to be a
production of dyes human carcinogen.
and to promote
adhesion of natural
rubber to steel.
Diethanolamine.............. Used in the Not listed.
preparation of
surfactants used in
liquid laundry,
dishwashing
detergents,
cosmetics,
shampoos, and hair
conditioners; as a
surface-active
agent and corrosion
inhibitor in
metalworking
fluids; and as a
dispersant in
agricultural
chemical
formulations.
Hepatitis B Virus........... A small DNA- Listed as known to
enveloped virus be a human
that, along with carcinogen.
Hepatitis C Virus,
causes most
parenterally
transmitted viral
hepatitis.
Hepatitis C Virus........... An RNA-enveloped Listed as known to
virus that, along be a human
with Hepatitis B carcinogen.
Virus, causes most
parenterally
transmitted viral
hepatitis.
Selected Heterocyclic Amines Heterocyclic amines Listed as reasonably
(three): that are formed anticipated to be
during grilling or human carcinogens.
cooking at high
temperature and are
found in cooked
meat and fish.
(1) 2-Amino-3,4-
dimethylimidazo[4,5-
f]quinoline (MeIQ)
(2) 2-Amino-3,8-
dimethylimidazo[4,5-
f]quinoxaline (MeIQx)
(3) 2-Amino-1-methyl-6-
phenylimidazo[4,5-
b]pyridine (PhIP)
Human Papillomaviruses, Some Small, non-enveloped Listed as known to
Genital-Mucosal Types. viruses that infect be human
genital skin, and carcinogens.
genital and non-
genital mucosa. HPV
infections are
common throughout
the world.
Lead and Lead Compounds..... Major use is in Listed as reasonably
making lead-acid anticipated to be
storage batteries. human carcinogens.
Other common uses
include ammunition
and cable covering.
Lead compounds are
used in paint,
glass, ceramics,
fuel additives, and
some traditional
cosmetics.
Naphthalene................. Used as an Listed as reasonably
intermediate in the anticipated to be a
synthesis of many human carcinogen.
industrial
chemicals, and has
been used as an
ingredient in some
moth repellants and
toilet bowl
deodorants.
Neutrons.................... Exposures normally Listed as known to
occur from a mixed be human
irradiation field carcinogens.
in which neutrons
are a minor
component. The
exceptions are
exposure of
patients to neutron
radiotherapy beams
and exposures of
aircraft passengers
and crew.
Nitrobenzene................ Used mainly in the Listed as reasonably
production of anticipated to be a
aniline, itself a human carcinogen.
major chemical
intermediate in the
production of dyes.
Nitromethane................ Used in specialized Listed as reasonably
fuels, in anticipated to be a
explosives, and in human carcinogen.
the synthesis of
nitromethane
derivatives,
pharmaceuticals,
agricultural soil
fumigants, and
industrial
antimicrobials.
4,4'-Thiodianiline.......... Used as an Listed as reasonably
intermediate of anticipated to be a
several diazo dyes. human carcinogen.
X-Radiation and Gamma Exposure to these Listed as known to
([gamma])-Radiation. forms of ionizing be human
radiation comes carcinogens.
from a variety of
natural
(environmental
exposure) and
anthropogenic
sources, including
exposure for
military, medical,
and occupational
purposes.
------------------------------------------------------------------------
[[Page 6723]]
[FR Doc. 05-2393 Filed 2-7-05; 8:45 am]
BILLING CODE 4140-01-U
