The National Toxicology Program (NTP) Announces the Availability of the Report on Carcinogens, Eleventh Edition, 6721-6723 [05-2393]

Download as PDF Federal Register / Vol. 70, No. 25 / Tuesday, February 8, 2005 / Notices Date: February 23, 2005. Time: 1 p.m. to 6 p.m. Agenda: To review and evaluate grant applications. Place: Bethesda North Marriott Hotel, 11200 Rockville Pike, Rockville, MD 20852. Contact Person: Karin F. Helmers, PhD, Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 3166, MSC 7770, Bethesda, MD 20892, 301–435– 1017, helmersk@csr.nih.gov. Name of Committee: Center for Scientific Review Special Emphasis Panel DNA Damage and Carcinogenesis. Date: February 25, 2005. Time: 2 p.m. to 3 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Hungyi Shau, PhD, Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 6214, MSC 7804, Bethesda, MD 20892, 301–435– 1720, shauhung@csr.nih.gov. Name of Committee: Center for Scientific Review Special Emphasis Panel ZRG1 ASG– 01 Q: Aging Systems and Geriatrics: Quorum. Date: February 28–March 1, 2005. Time: 8 a.m. to 4 p.m. Agenda: To review and evaluate grant applications. Place: Residence Inn Bethesda, 7335 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Sherry L. Dupere, PhD, Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5136, MSC 7840, Bethesda, MD 20892, 301–435– 1021, duperes@csr.nih.gov. Name of Committee: Center for Scientific Review Special Emphasis Panel Alcohol and Behavior. Date: February 28, 2005. Time: 3 p.m. to 4:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rocklecge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Christine L. Melchior, PhD, Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 5176, MSC 7844, Bethesda, MD 20892, 301–435– 1713, melchioc@csr.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393–93.396, 93.837–93.844, 93.846–93.878, 93.892, 93.893, National Institutes of Health, HHS). Dated: February 3, 2005. LaVerne Y. Stringfield, Director, Office of Federal Advisory Committee Policy. [FR Doc. 05–2405 Filed 2–7–05; 8:45 am] BILLING CODE 4140–01–M VerDate jul<14>2003 18:12 Feb 07, 2005 Jkt 205001 DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service The National Toxicology Program (NTP) Announces the Availability of the Report on Carcinogens, Eleventh Edition The Department of Health and Human Services released the Report on Carcinogens, Eleventh Edition to the public on January 31, 2005. The report is available free-of-charge on the Internet from the NTP Web site at: http:/ /ntp.niehs.nih.gov. Printed copies of the Report on Carcinogens, Eleventh Edition can be obtained by contacting: Central Data Management (CDM), MD–EC–03, National Institute of Environmental Health Sciences, P.O. Box 12233, 79 T.W. Alexander Dr., Building 4401, Suite 100, Research Triangle Park, NC 27709 USA; 919–541–3419 (phone), 919–541–3687 (fax), e-mail: cdm@niehs.nih.gov. Background The Report on Carcinogens (RoC) (previously known as the Annual Report on Carcinogens) is a Congressionally mandated listing of known human carcinogens and reasonably anticipated human carcinogens whose preparation is delegated to the NTP by the Secretary, Department of Health and Human Services (DHHS). Section 301(b)(4) of the Public Health Service Act, as amended, provides that the Secretary, DHHS, shall publish a biennial report which contains a list of all substances (1) which either are known to be human carcinogens or may reasonably be anticipated to be human carcinogens; and (2) to which a significant number of persons residing in the United States are exposed. The law also states that the reports should provide available information on the nature of exposures, the estimated number of persons exposed, and the extent to which the implementation of federal regulations decreases the risk to public health from exposure to these chemicals. The RoC is an informational, scientific, and public health document that identifies and discusses agents, substances, mixtures, or exposure circumstances that may pose a carcinogenic hazard to human health. It serves as a meaningful and useful compilation of data on the (1) carcinogenicity, genotoxicity, and biologic mechanisms of the listed substances in humans and/or animals, (2) the potential for exposure to these PO 00000 Frm 00110 Fmt 4703 Sfmt 4703 6721 substances, and (3) the regulations promulgated by Federal agencies to limit exposures. The report does not present quantitative assessments of carcinogenic risk, an assessment that defines the conditions under which the hazard may be unacceptable. Listing of substances in the report, therefore, does not establish that such substances present carcinogenic risks to individuals in their daily lives. Such formal risk assessments are the purview of the appropriate federal, state, and local health regulatory and research agencies. New Listings to the RoC, Eleventh Edition The RoC, Eleventh Edition, contains 246 entries, 17 of which have not appeared in earlier RoCs. The table below summarizes the actions taken for the substances or exposure circumstances reviewed for possible listing in the RoC, Eleventh Edition. The review of the new entries to the RoC, Eleventh Edition followed a formal process that included many phases of scientific peer review and multiple opportunities for public comment. The process included three scientific peer reviews: two separate, internal reviews conducted by scientists within the federal government and an external review in a public forum conducted by both non-government and government scientists. The three scientific review committees evaluated all available data relevant to the criteria for inclusion of candidate nominations in the report. The criteria used to evaluate the nominations and a description of the review procedures used are available on the NTP Web site at http:// ntp.niehs.nih.gov/ or by contacting: Dr. C. W. Jameson, Head—Report on Carcinogens, National Toxicology Program, National Institute of Environmental Health Sciences, MD EC–14, P.O. Box 12233, Research Triangle Park, NC 27709; phone: (919) 541–4096, fax: (919) 541–0144, e-mail: jameson@niehs.nih.gov. Questions or comments concerning the RoC, Eleventh Edition should be directed to: Dr. Mary Wolfe, NTP Liaison and Scientific Review Office, National Institute of Environmental Health Sciences, MD–A3, P.O. Box 12233, Research Triangle Park, NC 27709; phone: (919) 541–0530, fax: (919) 541–0295, e-mail: wolfe@niehs.nih.gov. Dated: January 31, 2005. Kenneth Olden, Director, National Toxicology Program. E:\FR\FM\08FEN1.SGM 08FEN1 6722 Federal Register / Vol. 70, No. 25 / Tuesday, February 8, 2005 / Notices SUMMARY OF ACTIONS FOR AGENTS, SUBSTANCES, MIXTURES OR EXPOSURE CIRCUMSTANCES REVIEWED FOR LISTING IN THE ELEVENTH EDITION OF THE REPORT ON CARCINOGENS Nominations Primary uses or exposures Action 1–Amino-2,4-dibromoanthraquinone .................. An anthraquinone-derived vat dye that is used in the textile industry. Used in electroplating and electrochemical industries. It is also used as a coloring agent for ceramics and as a drying agent in inks, paints, varnishes and linoleum, and has been added to animal feed as a mineral supplement. Used as an intermediate in the production of dyes and to promote adhesion of natural rubber to steel. Used in the preparation of surfactants used in liquid laundry, dishwashing detergents, cosmetics, shampoos, and hair conditioners; as a surface-active agent and corrosion inhibitor in metalworking fluids; and as a dispersant in agricultural chemical formulations. A small DNA-enveloped virus that, along with Hepatitis C Virus, causes most parenterally transmitted viral hepatitis. An RNA-enveloped virus that, along with Hepatitis B Virus, causes most parenterally transmitted viral hepatitis. Heterocyclic amines that are formed during grilling or cooking at high temperature and are found in cooked meat and fish. Listed as reasonably anticipated to be a human carcinogen. Listed as reasonably anticipated to be a human carcinogen. Small, non-enveloped viruses that infect genital skin, and genital and non-genital mucosa. HPV infections are common throughout the world. Major use is in making lead-acid storage batteries. Other common uses include ammunition and cable covering. Lead compounds are used in paint, glass, ceramics, fuel additives, and some traditional cosmetics. Used as an intermediate in the synthesis of many industrial chemicals, and has been used as an ingredient in some moth repellants and toilet bowl deodorants. Exposures normally occur from a mixed irradiation field in which neutrons are a minor component. The exceptions are exposure of patients to neutron radiotherapy beams and exposures of aircraft passengers and crew. Used mainly in the production of aniline, itself a major chemical intermediate in the production of dyes. Used in specialized fuels, in explosives, and in the synthesis of nitromethane derivatives, pharmaceuticals, agricultural soil fumigants, and industrial antimicrobials. Used as an intermediate of several diazo dyes. Exposure to these forms of ionizing radiation comes from a variety of natural (environmental exposure) and anthropogenic sources, including exposure for military, medical, and occupational purposes. Listed as known to be human carcinogens. Cobalt Sulfate ..................................................... Diazoaminobenzene ........................................... Diethanolamine ................................................... Hepatitis B Virus ................................................. Hepatitis C Virus ................................................ Selected Heterocyclic Amines (three): (1) 2-Amino-3,4-dimethylimidazo[4,5f]quinoline (MeIQ) (2) 2-Amino-3,8-dimethylimidazo[4,5f]quinoxaline (MeIQx) (3) 2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) Human Papillomaviruses, Some GenitalMucosal Types. Lead and Lead Compounds ............................... Naphthalene ....................................................... Neutrons ............................................................. Nitrobenzene ...................................................... Nitromethane ...................................................... 4,4’-Thiodianiline ................................................ X–Radiation and Gamma (g)-Radiation ............. VerDate jul<14>2003 18:12 Feb 07, 2005 Jkt 205001 PO 00000 Frm 00111 Fmt 4703 Sfmt 4703 Listed as reasonably anticipated to be a human carcinogen. Not listed. Listed as known to be a human carcinogen. Listed as known to be a human carcinogen. Listed as reasonably anticipated to be human carcinogens. Listed as reasonably anticipated to be human carcinogens. Listed as reasonably anticipated to be a human carcinogen. Listed as known to be human carcinogens. Listed as reasonably anticipated to be a human carcinogen. Listed as reasonably anticipated to be a human carcinogen. Listed as reasonably anticipated to be a human carcinogen. Listed as known to be human carcinogens. E:\FR\FM\08FEN1.SGM 08FEN1 Federal Register / Vol. 70, No. 25 / Tuesday, February 8, 2005 / Notices [FR Doc. 05–2393 Filed 2–7–05; 8:45 am] BILLING CODE 4140–01–U DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG–2004–18949] Collection of Information Under Review by Office of Management and Budget (OMB): 1625–0006 (Formerly 2115–0015), Shipping Articles Coast Guard, DHS. Request for comments. AGENCY: ACTION: SUMMARY: In compliance with the Paperwork Reduction Act of 1995, this request for comments announces that the Coast Guard has forwarded one Information Collection Report (ICR)— 1625–0006, Shipping Articles— abstracted below, to the Office of Information and Regulatory Affairs (OIRA) of the Office of Management and Budget (OMB) for review and comment. Our ICR describes the information we seek to collect from the public. Review and comment by OIRA ensures that we impose only paperwork burdens commensurate with our performance of duties. DATES: Please submit your comments on or before March 10, 2005. ADDRESSES: To make sure that your comments and related material do not reach the docket [USCG–2004–18949] or OIRA more than once, please submit them by only one of the following means: (1)(a) By mail to the Docket Management Facility, U.S. Department of Transportation (DOT), room PL–401, 400 Seventh Street SW., Washington, DC 20590–0001. (b) By mail to OIRA, 725 17th St., NW., Washington, DC 20503, to the attention of the Desk Officer for the Coast Guard. (2)(a) By delivery to room PL–401 at the address given in paragraph (1)(a) above, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. The telephone number is (202) 366–9329. (b) By delivery to OIRA, at the address given in paragraph (1)(b) above, to the attention of the Desk Officer for the Coast Guard. (3) By fax to (a) the Facility at (202) 493–2298 and (b) OIRA at (202) 395– 6566, or e-mail to OIRA at oiradocket@omb.eop.gov attention: Desk Officer for the Coast Guard. (4)(a) Electronically through the Web Site for the Docket Management System at http://dms.dot.gov. (b) OIRA does not have a Web site on which you can post your comments. VerDate jul<14>2003 18:12 Feb 07, 2005 Jkt 205001 The Docket Management Facility maintains the public docket for this notice. Comments and material received from the public, as well as documents mentioned in this notice as being available in the docket, will become part of this docket and will be available for inspection or copying at room PL–401 on the Plaza level of the Nassif Building, 400 Seventh Street, SW., Washington, DC, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. You may also find this docket on the Internet at http://dms.dot.gov. Copies of the complete ICR are available through this docket on the Internet at http://dms.dot.gov, and also from Commandant (CG–611), U.S. Coast Guard Headquarters, room 6106 (Attn: Ms. Barbara Davis), 2100 Second Street, SW., Washington, DC 20593–0001. The telephone number is (202) 267–2326. Ms. Barbara Davis, Office of Information Management, telephone (202) 267–2326 or fax (202) 267–4814, for questions on these documents; or Ms. Andrea M. Jenkins, Program Manager, Docket Operations, (202) 366–0271, for questions on the docket. FOR FURTHER INFORMATION CONTACT: The Coast Guard invites comments on the proposed collection of information to determine whether the collections are necessary for the proper performance of the functions of the Department. In particular, the Coast Guard would appreciate comments addressing: (1) The practical utility of the collections; (2) the accuracy of the estimated burden of the collections; (3) ways to enhance the quality, utility, and clarity of the information that is the subject of the collections; and (4) ways to minimize the burden of collections on respondents, including the use of automated collection techniques or other forms of information technology. Comments to DMS or OIRA must contain the OMB Control Number of the Information Collection Reports (ICR) addressed. Comments to DMS must contain the docket number of this request, [USCG 2004–18949]. Comments to OIRA are best assured of having their full effect if OIRA receives them on or before March 10, 2005. Public participation and request for comments: We encourage you to participate in this request for comments by submitting comments and related materials. We will post all comments received, without change, to http:// dms.dot.gov, and they will include any personal information you have provided. We have an agreement with DOT to use their Docket Management SUPPLEMENTARY INFORMATION: PO 00000 Frm 00112 Fmt 4703 Sfmt 4703 6723 Facility. Please see the paragraph on DOT’s ‘‘Privacy Act Policy’’ below. Submitting comments: If you submit a comment, please include your name and address, identify the docket number for this request for comment [USCG–2004– 18949], indicate the specific section of this document or the ICR to which each comment applies, and give the reason for each comment. You may submit your comments and material by electronic means, mail, fax, or delivery to the Docket Management Facility at the address under ADDRESSES, but please submit them by only one means. If you submit them by mail or delivery, submit them in an unbound format, no larger than 81⁄2 by 11 inches, suitable for copying and electronic filing. If you submit them by mail and would like to know that they reached the Facility, please enclose a stamped, self-addressed postcard or envelope. We will consider all comments and material received during the comment period. We may change the documents supporting this collection of information or even the underlying requirements in view of them. Viewing comments and documents: To view comments, as well as documents mentioned in this notice as being available in the docket, go to http://dms.dot.gov at any time and conduct a simple search using the docket number. You may also visit the Docket Management Facility in room PL–401 on the Plaza level of the Nassif Building, 400 Seventh Street, SW., Washington, DC, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. Privacy Act: Anyone can search the electronic form of all comments received in dockets by the name of the individual submitting the comment (or signing the comment, if submitted on behalf of an association, business, labor union, etc.). You may review the Privacy Act Statement of DOT in the Federal Register published on April 11, 2000 (65 FR 19477), or you may visit http://dms.dot.gov. Previous Request for Comments This request provides a 30-day comment period required by OIRA. The Coast Guard has already published the 60-day notice required by 44 U.S.C. 3506(c)(2) (69 FR 54301, September 8, 2004). That notice elicited one comment. The commenter noted that form CG–705A—Shipping Articles, should be revised, including an altering of the layout to a more standard size, utilizing IT (i.e. online) if possible. The Coast Guard agrees that form CG–705A is long overdue for updating and redesign. The Coast Guard will, E:\FR\FM\08FEN1.SGM 08FEN1

Agencies

[Federal Register Volume 70, Number 25 (Tuesday, February 8, 2005)]
[Notices]
[Pages 6721-6723]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 05-2393]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service


The National Toxicology Program (NTP) Announces the Availability 
of the Report on Carcinogens, Eleventh Edition

    The Department of Health and Human Services released the Report on 
Carcinogens, Eleventh Edition to the public on January 31, 2005. The 
report is available free-of-charge on the Internet from the NTP Web 
site at: http://ntp.niehs.nih.gov. Printed copies of the Report on 
Carcinogens, Eleventh Edition can be obtained by contacting: Central 
Data Management (CDM), MD-EC-03, National Institute of Environmental 
Health Sciences, P.O. Box 12233, 79 T.W. Alexander Dr., Building 4401, 
Suite 100, Research Triangle Park, NC 27709 USA; 919-541-3419 (phone), 
919-541-3687 (fax), e-mail: cdm@niehs.nih.gov.

Background

    The Report on Carcinogens (RoC) (previously known as the Annual 
Report on Carcinogens) is a Congressionally mandated listing of known 
human carcinogens and reasonably anticipated human carcinogens whose 
preparation is delegated to the NTP by the Secretary, Department of 
Health and Human Services (DHHS). Section 301(b)(4) of the Public 
Health Service Act, as amended, provides that the Secretary, DHHS, 
shall publish a biennial report which contains a list of all substances 
(1) which either are known to be human carcinogens or may reasonably be 
anticipated to be human carcinogens; and (2) to which a significant 
number of persons residing in the United States are exposed. The law 
also states that the reports should provide available information on 
the nature of exposures, the estimated number of persons exposed, and 
the extent to which the implementation of federal regulations decreases 
the risk to public health from exposure to these chemicals.
    The RoC is an informational, scientific, and public health document 
that identifies and discusses agents, substances, mixtures, or exposure 
circumstances that may pose a carcinogenic hazard to human health. It 
serves as a meaningful and useful compilation of data on the (1) 
carcinogenicity, genotoxicity, and biologic mechanisms of the listed 
substances in humans and/or animals, (2) the potential for exposure to 
these substances, and (3) the regulations promulgated by Federal 
agencies to limit exposures. The report does not present quantitative 
assessments of carcinogenic risk, an assessment that defines the 
conditions under which the hazard may be unacceptable. Listing of 
substances in the report, therefore, does not establish that such 
substances present carcinogenic risks to individuals in their daily 
lives. Such formal risk assessments are the purview of the appropriate 
federal, state, and local health regulatory and research agencies.

New Listings to the RoC, Eleventh Edition

    The RoC, Eleventh Edition, contains 246 entries, 17 of which have 
not appeared in earlier RoCs. The table below summarizes the actions 
taken for the substances or exposure circumstances reviewed for 
possible listing in the RoC, Eleventh Edition.
    The review of the new entries to the RoC, Eleventh Edition followed 
a formal process that included many phases of scientific peer review 
and multiple opportunities for public comment. The process included 
three scientific peer reviews: two separate, internal reviews conducted 
by scientists within the federal government and an external review in a 
public forum conducted by both non-government and government 
scientists. The three scientific review committees evaluated all 
available data relevant to the criteria for inclusion of candidate 
nominations in the report. The criteria used to evaluate the 
nominations and a description of the review procedures used are 
available on the NTP Web site at http://ntp.niehs.nih.gov/ or by 
contacting: Dr. C. W. Jameson, Head--Report on Carcinogens, National 
Toxicology Program, National Institute of Environmental Health 
Sciences, MD EC-14, P.O. Box 12233, Research Triangle Park, NC 27709; 
phone: (919) 541-4096, fax: (919) 541-0144, e-mail: 
jameson@niehs.nih.gov.
    Questions or comments concerning the RoC, Eleventh Edition should 
be directed to: Dr. Mary Wolfe, NTP Liaison and Scientific Review 
Office, National Institute of Environmental Health Sciences, MD-A3, 
P.O. Box 12233, Research Triangle Park, NC 27709; phone: (919) 541-
0530, fax: (919) 541-0295, e-mail: wolfe@niehs.nih.gov.

    Dated: January 31, 2005.
Kenneth Olden,
Director, National Toxicology Program.

[[Page 6722]]



     Summary of Actions for Agents, Substances, Mixtures or Exposure
Circumstances Reviewed for Listing in the Eleventh Edition of the Report
                             on Carcinogens
------------------------------------------------------------------------
                                 Primary uses or
         Nominations                exposures              Action
------------------------------------------------------------------------
1-Amino-2,4-                  An anthraquinone-     Listed as reasonably
 dibromoanthraquinone.         derived vat dye       anticipated to be a
                               that is used in the   human carcinogen.
                               textile industry.
Cobalt Sulfate..............  Used in               Listed as reasonably
                               electroplating and    anticipated to be a
                               electrochemical       human carcinogen.
                               industries. It is
                               also used as a
                               coloring agent for
                               ceramics and as a
                               drying agent in
                               inks, paints,
                               varnishes and
                               linoleum, and has
                               been added to
                               animal feed as a
                               mineral supplement.
Diazoaminobenzene...........  Used as an            Listed as reasonably
                               intermediate in the   anticipated to be a
                               production of dyes    human carcinogen.
                               and to promote
                               adhesion of natural
                               rubber to steel.
Diethanolamine..............  Used in the           Not listed.
                               preparation of
                               surfactants used in
                               liquid laundry,
                               dishwashing
                               detergents,
                               cosmetics,
                               shampoos, and hair
                               conditioners; as a
                               surface-active
                               agent and corrosion
                               inhibitor in
                               metalworking
                               fluids; and as a
                               dispersant in
                               agricultural
                               chemical
                               formulations.
Hepatitis B Virus...........  A small DNA-          Listed as known to
                               enveloped virus       be a human
                               that, along with      carcinogen.
                               Hepatitis C Virus,
                               causes most
                               parenterally
                               transmitted viral
                               hepatitis.
Hepatitis C Virus...........  An RNA-enveloped      Listed as known to
                               virus that, along     be a human
                               with Hepatitis B      carcinogen.
                               Virus, causes most
                               parenterally
                               transmitted viral
                               hepatitis.
Selected Heterocyclic Amines  Heterocyclic amines   Listed as reasonably
 (three):                      that are formed       anticipated to be
                               during grilling or    human carcinogens.
                               cooking at high
                               temperature and are
                               found in cooked
                               meat and fish.
    (1) 2-Amino-3,4-
     dimethylimidazo[4,5-
     f]quinoline (MeIQ)
    (2) 2-Amino-3,8-
     dimethylimidazo[4,5-
     f]quinoxaline (MeIQx)
    (3) 2-Amino-1-methyl-6-
     phenylimidazo[4,5-
     b]pyridine (PhIP)
Human Papillomaviruses, Some  Small, non-enveloped  Listed as known to
 Genital-Mucosal Types.        viruses that infect   be human
                               genital skin, and     carcinogens.
                               genital and non-
                               genital mucosa. HPV
                               infections are
                               common throughout
                               the world.
Lead and Lead Compounds.....  Major use is in       Listed as reasonably
                               making lead-acid      anticipated to be
                               storage batteries.    human carcinogens.
                               Other common uses
                               include ammunition
                               and cable covering.
                               Lead compounds are
                               used in paint,
                               glass, ceramics,
                               fuel additives, and
                               some traditional
                               cosmetics.
Naphthalene.................  Used as an            Listed as reasonably
                               intermediate in the   anticipated to be a
                               synthesis of many     human carcinogen.
                               industrial
                               chemicals, and has
                               been used as an
                               ingredient in some
                               moth repellants and
                               toilet bowl
                               deodorants.
Neutrons....................  Exposures normally    Listed as known to
                               occur from a mixed    be human
                               irradiation field     carcinogens.
                               in which neutrons
                               are a minor
                               component. The
                               exceptions are
                               exposure of
                               patients to neutron
                               radiotherapy beams
                               and exposures of
                               aircraft passengers
                               and crew.
Nitrobenzene................  Used mainly in the    Listed as reasonably
                               production of         anticipated to be a
                               aniline, itself a     human carcinogen.
                               major chemical
                               intermediate in the
                               production of dyes.
Nitromethane................  Used in specialized   Listed as reasonably
                               fuels, in             anticipated to be a
                               explosives, and in    human carcinogen.
                               the synthesis of
                               nitromethane
                               derivatives,
                               pharmaceuticals,
                               agricultural soil
                               fumigants, and
                               industrial
                               antimicrobials.
4,4'-Thiodianiline..........  Used as an            Listed as reasonably
                               intermediate of       anticipated to be a
                               several diazo dyes.   human carcinogen.
X-Radiation and Gamma         Exposure to these     Listed as known to
 ([gamma])-Radiation.          forms of ionizing     be human
                               radiation comes       carcinogens.
                               from a variety of
                               natural
                               (environmental
                               exposure) and
                               anthropogenic
                               sources, including
                               exposure for
                               military, medical,
                               and occupational
                               purposes.
------------------------------------------------------------------------


[[Page 6723]]

[FR Doc. 05-2393 Filed 2-7-05; 8:45 am]
BILLING CODE 4140-01-U