Government-Owned Inventions; Availability for Licensing, 39443-39444 [2017-17438]

Download as PDF Federal Register / Vol. 82, No. 159 / Friday, August 18, 2017 / Notices (Catalogue of Federal Domestic Assistance Program No. 93.242, Mental Health Research Grants, National Institutes of Health, HHS) Dated: August 14, 2017. Melanie J. Pantoja, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2017–17430 Filed 8–17–17; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health [FR Doc. 2017–17428 Filed 8–17–17; 8:45 am] mstockstill on DSK30JT082PROD with NOTICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Alcohol Abuse and Alcoholism Initial Review Group Epidemiology, Prevention and Behavior Research Review Subcommittee. Date: October 23, 2017. Time: 8:30 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Terrace Level Conference Rooms, 5635 Fishers Lane, Rockville, MD 20852. Contact Person: Anna Ghambaryan, M.D., Ph.D., Scientific Review Officer, Extramural Project Review Branch, Office of Extramural Activities, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2019, Rockville, MD 20852, 301–443–4032, anna.ghambaryan@nih.gov. Name of Committee: National Institute on Alcohol Abuse and Alcoholism Initial Review Group Clinical, Treatment and Health Services Research Review Subcommittee. Date: November 1, 2017. Time: 8:30 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Terrace Level Conference Room 508, 5635 Fishers Lane, Rockville, MD 20852 Contact Person: Ranga V. Srinivas, Ph.D. Chief Extramural Project Review, Branch 17:47 Aug 17, 2017 Jkt 241001 (Catalogue of Federal Domestic Assistance Program Nos. 93.271, Alcohol Research Career Development Awards for Scientists and Clinicians; 93.272, Alcohol National Research Service Awards for Research Training; 93.273, Alcohol Research Programs; 93.891, Alcohol Research Center Grants; 93.701, ARRA Related Biomedical Research and Research Support Awards., National Institutes of Health, HHS) Dated: August 14, 2017. Melanie J. Pantoja, Program Analyst, Office of Federal Advisory Committee Policy. National Institute on Alcohol Abuse and Alcoholism; Notice of Closed Meetings VerDate Sep<11>2014 National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5365 Fishers Lane, Room 2085, Rockville, MD 20852, (301) 451–2067 srinivar@ mail.nih.gov. BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, HHS. ACTION: Notice. The invention listed below is owned by an agency of the U.S. Government and is available for licensing to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. FOR FURTHER INFORMATION CONTACT: Peter Soukas, J.D., (301) 594–8730; peter.soukas@nih.gov. Licensing information and copies of the patent applications listed below may be obtained by communicating with the indicated licensing contact at the Technology Transfer and Intellectual Property Office, National Institute of Allergy and Infectious Diseases, 5601 Fishers Lane, Rockville, MD, 20852; tel. (301) 496–2644. A signed Confidential Disclosure Agreement will be required to receive copies of unpublished patent applications. SUPPLEMENTARY INFORMATION: Technology description follows. SUMMARY: Development of a Transferrable Norwalk Virus Epitope and Detector Monoclonal Antibody Description of Technology Noroviruses are now recognized as the major cause of non-bacterial PO 00000 Frm 00040 Fmt 4703 Sfmt 4703 39443 gastroenteritis in all age groups, and efforts are underway to develop an effective vaccine. The lack of a robust cell culture system for human noroviruses has complicated vaccine development. Hence, norovirus virus like particles (VLPs) have played an important role in the understanding of virus structure, immune response, antigenic diversity, and vaccine design. The development of monoclonal antibodies (MAbs) against norovirus VLPs has allowed the identification and characterization of key antigenic sites of the virus capsid and facilitated the development of diagnostic assays. During characterization of a panel of MAbs raised against Norwalk virus (NV), a prototype norovirus strain, the inventors identified a monoclonal antibody (MAbNV10) that proved useful in the identification of NV in tissue and in the characterization of an insertion site in the feline calicivirus (FCV) genome. The inventors mapped the precise binding site of the MAb by peptide screening and discovered that the epitope could be expressed when fused to other proteins. The sequence of this peptide (epitope) along with the detector antibody could be used as a new way to tag proteins for functional studies. The small size of the linear epitope, along with the strong avidity of the detector monoclonal antibody makes this system especially useful for many techniques, including immunofluorescence, Western blot, immunoprecipitation (including ‘‘pulldown’’ assays), and immunohistochemistry. The inventors’ epitope system may be comparable to that of the HA tag of influenza virus that is widely used in molecular biology. This technology is further described in Parra et al., ‘‘Mapping and modeling of a strain-specific epitope in the Norwalk virus capsid inner shell,’’ Virology. 2016 May;492:232–41. doi: 10.1016/j.virol.2016.02.019. Epub 2016 Mar 21. Materials available for licensing comprise: (1) Hybridoma cell line NV10, (2) Plasmid expressing NV10 epitope as positive control, and (3) Plasmid expressing the NV10 scFV. This technology is available for licensing for commercial development in accordance with 35 U.S.C. 209 and 37 CFR part 404, as well as for further development and evaluation under a research collaboration. Potential Commercial Applications • Diagnostics • Vaccines Competitive Advantages • Cross-reactive norovirus antibody E:\FR\FM\18AUN1.SGM 18AUN1 39444 Federal Register / Vol. 82, No. 159 / Friday, August 18, 2017 / Notices • Ease of manufacture • Efficient norovirus detection Development Stage • In vivo data available (animal) Inventors: Kim Green, Ph.D. (NIAID); Gabriel Parra, Ph.D. (NIAID); Stanislav Sosnovtsev, Ph.D. (NIAID); Karin Bok, Ph.D. (NIAID); Carlos Sandoval-Jaime, Ph.D. (NIAID); Eugenio Abente, Ph.D. (NIAID) Intellectual Property: HHS Reference No. E–101–2013/0. Licensing Contact: Peter Soukas, J.D., (301) 594–8730; peter.soukas@nih.gov. Collaborative Research Opportunity: The National Institute of Allergy and Infectious Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize norovirus diagnostics or vaccines. For collaboration opportunities, please contact Peter Soukas, J.D., (301) 594–8730; peter.soukas@nih.gov. Dated: August 3, 2017. Suzanne Frisbie, Deputy Director, Technology Transfer and Intellectual Property Office, National Institute of Allergy and Infectious Diseases. [FR Doc. 2017–17438 Filed 8–17–17; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Advancing Translational Sciences; Notice of Closed Meeting mstockstill on DSK30JT082PROD with NOTICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The contract proposals and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the contract proposals, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Center for Advancing Translational Sciences Special Emphasis Panel Contract Review. Date: September 12, 2017. Time: 1:00 p.m. to 4:00 p.m. Agenda: To review and evaluate contract proposals. Place: National Institutes of Health, One Democracy Plaza, Room 1037, 6701 VerDate Sep<11>2014 17:47 Aug 17, 2017 Jkt 241001 Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Rahat (Rani) Khan, Ph.D., Scientific Review Officer, Office of Scientific Review, National Center for Advancing, Translational Sciences, 6701 Democracy Blvd., Rm 1078, Bethesda, MD 20892, 301– 894–7319, khanr2@csr.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.859, Pharmacology, Physiology, and Biological Chemistry Research; 93.350, B—Cooperative Agreements; 93.859, Biomedical Research and Research Training, National Institutes of Health, HHS) Dated: August 14, 2017. David Clary, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2017–17427 Filed 8–17–17; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended, notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Biomedical Imaging and Bioengineering Special Emphasis Panel; NIBIB Team-Based R25 Review (2018/01). Date: September 28, 2017. Time: 09:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Two Democracy Plaza, Suite 920, 6707 Democracy Boulevard, Bethesda, MD 20892, (Virtual Meeting). Contact Person: Ruixia Zhou, Ph.D., Scientific Review Officer, 6707 Democracy Boulevard, Democracy Two Building, Suite 957, Bethesda, MD 20892, (301) 496–4773, zhour@mail.nih.gov. Name of Committee: National Institute of Biomedical Imaging and Bioengineering Special Emphasis Panel; T32–R25 Review Meeting (2018/01). Date: October 24, 2017. Time: 09:30 a.m. to 7:00 p.m. PO 00000 Frm 00041 Fmt 4703 Sfmt 4703 Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Two Democracy Plaza, Suite 920, 6707 Democracy Boulevard, Bethesda, MD 20892, (Virtual Meeting). Contact Person: John K. Hayes, Ph.D., Scientific Review Officer, 6707 Democracy Blvd., Suite 959, Democracy Two, Bethesda, MD 20892, (301) 451–3398, hayesj@ mail.nih.gov. Dated: August 14, 2017. David Clary, Program Analyst, Office of Federal Advisory Committee Policy. [FR Doc. 2017–17429 Filed 8–17–17; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services [OMB Control Number 1615–0120] Agency Information Collection Activities; Extension, Without Change, of a Currently Approved Collection; Free Training for Civics and Citizenship of Adults, Form G–1190; Civics and Citizenship Toolkit, Form G–1515 U.S. Citizenship and Immigration Services, Department of Homeland Security. ACTION: 30-Day notice. AGENCY: The Department of Homeland Security (DHS), U.S. Citizenship and Immigration Services (USCIS) will be submitting the following information collection request to the Office of Management and Budget (OMB) for review and clearance in accordance with the Paperwork Reduction Act of 1995. The purpose of this notice is to allow an additional 30 days for public comments. DATES: The purpose of this notice is to allow an additional 30 days for public comments. Comments are encouraged and will be accepted until September 18, 2017. This process is conducted in accordance with 5 CFR 1320.10. ADDRESSES: Written comments and/or suggestions regarding the item(s) contained in this notice, especially regarding the estimated public burden and associated response time, must be directed to the OMB USCIS Desk Officer via email at dhsdeskofficer@ omb.eop.gov. All submissions received must include the agency name and the OMB Control Number 1615–0120 in the subject line. You may wish to consider limiting the amount of personal information that you SUMMARY: E:\FR\FM\18AUN1.SGM 18AUN1

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[Federal Register Volume 82, Number 159 (Friday, August 18, 2017)]
[Notices]
[Pages 39443-39444]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2017-17438]



-----------------------------------------------------------------------



DEPARTMENT OF HEALTH AND HUMAN SERVICES



National Institutes of Health




Government-Owned Inventions; Availability for Licensing



AGENCY: National Institutes of Health, HHS.



ACTION: Notice.



-----------------------------------------------------------------------



SUMMARY: The invention listed below is owned by an agency of the U.S. 

Government and is available for licensing to achieve expeditious 

commercialization of results of federally-funded research and 

development. Foreign patent applications are filed on selected 

inventions to extend market coverage for companies and may also be 

available for licensing.



FOR FURTHER INFORMATION CONTACT: Peter Soukas, J.D., (301) 594-8730; 

peter.soukas@nih.gov. Licensing information and copies of the patent 

applications listed below may be obtained by communicating with the 

indicated licensing contact at the Technology Transfer and Intellectual 

Property Office, National Institute of Allergy and Infectious Diseases, 

5601 Fishers Lane, Rockville, MD, 20852; tel. (301) 496-2644. A signed 

Confidential Disclosure Agreement will be required to receive copies of 

unpublished patent applications.



SUPPLEMENTARY INFORMATION: Technology description follows.



Development of a Transferrable Norwalk Virus Epitope and Detector 

Monoclonal Antibody



Description of Technology



    Noroviruses are now recognized as the major cause of non-bacterial 

gastroenteritis in all age groups, and efforts are underway to develop 

an effective vaccine. The lack of a robust cell culture system for 

human noroviruses has complicated vaccine development. Hence, norovirus 

virus like particles (VLPs) have played an important role in the 

understanding of virus structure, immune response, antigenic diversity, 

and vaccine design. The development of monoclonal antibodies (MAbs) 

against norovirus VLPs has allowed the identification and 

characterization of key antigenic sites of the virus capsid and 

facilitated the development of diagnostic assays. During 

characterization of a panel of MAbs raised against Norwalk virus (NV), 

a prototype norovirus strain, the inventors identified a monoclonal 

antibody (MAbNV10) that proved useful in the identification of NV in 

tissue and in the characterization of an insertion site in the feline 

calicivirus (FCV) genome. The inventors mapped the precise binding site 

of the MAb by peptide screening and discovered that the epitope could 

be expressed when fused to other proteins. The sequence of this peptide 

(epitope) along with the detector antibody could be used as a new way 

to tag proteins for functional studies. The small size of the linear 

epitope, along with the strong avidity of the detector monoclonal 

antibody makes this system especially useful for many techniques, 

including immunofluorescence, Western blot, immunoprecipitation 

(including ``pulldown'' assays), and immunohistochemistry. The 

inventors' epitope system may be comparable to that of the HA tag of 

influenza virus that is widely used in molecular biology.

    This technology is further described in Parra et al., ``Mapping and 

modeling of a strain-specific epitope in the Norwalk virus capsid inner 

shell,'' Virology. 2016 May;492:232-41. doi: 10.1016/

j.virol.2016.02.019. Epub 2016 Mar 21.

    Materials available for licensing comprise: (1) Hybridoma cell line 

NV10, (2) Plasmid expressing NV10 epitope as positive control, and (3) 

Plasmid expressing the NV10 scFV.

    This technology is available for licensing for commercial 

development in accordance with 35 U.S.C. 209 and 37 CFR part 404, as 

well as for further development and evaluation under a research 

collaboration.



Potential Commercial Applications



 Diagnostics

 Vaccines



Competitive Advantages



 Cross-reactive norovirus antibody



[[Page 39444]]



 Ease of manufacture

 Efficient norovirus detection



Development Stage



 In vivo data available (animal)



    Inventors: Kim Green, Ph.D. (NIAID); Gabriel Parra, Ph.D. (NIAID); 

Stanislav Sosnovtsev, Ph.D. (NIAID); Karin Bok, Ph.D. (NIAID); Carlos 

Sandoval-Jaime, Ph.D. (NIAID); Eugenio Abente, Ph.D. (NIAID)

    Intellectual Property: HHS Reference No. E-101-2013/0.

    Licensing Contact: Peter Soukas, J.D., (301) 594-8730; 

peter.soukas@nih.gov. Collaborative Research Opportunity: The National 

Institute of Allergy and Infectious Diseases is seeking statements of 

capability or interest from parties interested in collaborative 

research to further develop, evaluate or commercialize norovirus 

diagnostics or vaccines. For collaboration opportunities, please 

contact Peter Soukas, J.D., (301) 594-8730; peter.soukas@nih.gov.



    Dated: August 3, 2017.

Suzanne Frisbie,

Deputy Director, Technology Transfer and Intellectual Property Office, 

National Institute of Allergy and Infectious Diseases.

[FR Doc. 2017-17438 Filed 8-17-17; 8:45 am]

BILLING CODE 4140-01-P
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