Government-Owned Inventions; Availability for Licensing, 11235 [2017-03306]
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Federal Register / Vol. 82, No. 33 / Tuesday, February 21, 2017 / Notices
Contact Person: Reigh-Yi Lin, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, 6701 Rockledge Drive,
Bethesda, MD 20892, 301–827–6009,
lin.reigh-yi@nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; PAR 16–
366—Dual Purpose with Dual Benefit:
Research in Biomedicine and Agriculture.
Date: March 21, 2017.
Time: 8:00 a.m. to 6:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: Hyatt Regency Bethesda, One
Bethesda Metro Center, 7400 Wisconsin
Avenue, Bethesda, MD 20814.
Contact Person: Tera Bounds, DVM, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3214,
MSC 7808, Bethesda, MD 20892, 301–435–
2306, boundst@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel;
Fellowships: Risk, Prevention and Health
Behavior Overflow.
Date: March 21, 2017.
Time: 9:00 a.m. to 1:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Stacey C. FitzSimmons,
Ph.D., Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3114,
MSC 7808, Bethesda, MD 20892, (301) 451–
9956, fitzsimmonss@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Urology and
Urogynecology Small Business Applications.
Date: March 21, 2017.
Time: 9:00 a.m. to 12:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Ganesan Ramesh, Ph.D.,
Center for Scientific Review, National
Institutes of Health, 6701 Rockledge Dr.,
Room 2182, MSC 7818, Bethesda, MD 20892,
ganesan.ramesh@nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Member
Conflict: Topics in drug discovery and
clinical field studies.
Date: March 21, 2017.
Time: 10:00 a.m. to 5:00 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Virtual Meeting).
Contact Person: Liangbiao Zheng, Ph.D.,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3202,
MSC 7808, Bethesda, MD 20892, 301–996–
5819, zhengli@csr.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.306, Comparative Medicine;
93.333, Clinical Research, 93.306, 93.333,
93.337, 93.393–93.396, 93.837–93.844,
VerDate Sep<11>2014
17:15 Feb 17, 2017
Jkt 241001
93.846–93.878, 93.892, 93.893, National
Institutes of Health, HHS)
Dated: February 14, 2017.
Natasha M. Copeland,
Program Analyst, Office of Federal Advisory
Committee Policy.
[FR Doc. 2017–03281 Filed 2–17–17; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions;
Availability for Licensing
AGENCY:
National Institutes of Health,
HHS.
ACTION:
Notice.
The inventions listed below
are owned by an agency of the U.S.
Government.
FOR FURTHER INFORMATION CONTACT:
Licensing information may be obtained
by emailing the indicated licensing
contact at the National Heart, Lung, and
Blood, Office of Technology Transfer
and Development Office of Technology
Transfer, 31 Center Drive, Room 4A29,
MSC2479, Bethesda, MD 20892–2479;
telephone: 301–402–5579. A signed
Confidential Disclosure Agreement may
be required to receive any unpublished
information.
SUPPLEMENTARY INFORMATION: The
following inventions are available for
licensing in accordance with 35 U.S.C.
209 and 37 CFR part 404 to achieve
expeditious commercialization of
results of federally-funded research and
development. Technology description
follows.
SUMMARY:
Methods for Improving Drug Delivery
to the Central Nervous System
The invention relates to the uses of
the tricyclic antidepressant
amitriptyline, its bioactive metabolites,
and other LPA1R activators to improve
the bioavailability and delivery of
therapeutics to the central nervous
system. This invention demonstrates
that amitriptyline and other agents
selectively decrease P-glycoprotein (Pgp) transport activity by ligand
activation of lysophosphatidic acid 1
receptor (LPA1R) at the blood-brain
barrier. P-gp is an effective target for
increasing drug delivery to the brain
(CNS) for two major reasons: (1) Its
substrates include a large portion of onthe-market drugs, including
chemotherapeutics, and (2) its
directionality results in a net efflux of
drugs from the brain. Additionally,
specifically targeting P-gp through
PO 00000
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Fmt 4703
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11235
LPA1R activation bypasses the clinical
challenges resulting from the toxicity of
substrate inhibitors of P-gp. This
invention describes the inhibition of
drug efflux by P-gp transport; thus, coadministration of therapeutics with
amitriptyline and other LPA1R
activators provides a method for
increasing drug delivery to the CNS, and
improving overall drug efficacy.
Moreover, drug delivery to other barrier
tissues will also be enhanced where a
similar LPA1R–P-gp activity
relationship exists.
Potential Commercial Applications:
• Drug Delivery to the CNS.
• Co-administration of therapeutics.
• Blood-brain-barrier permeability.
Development Stage:
• Early stage.
Inventors: Ronald Cannon and David
Banks (NIEHS).
Publications:
• Cannon et al., Neurosci Lett. 2017
Feb 3;639:103–113 doi: 10.1016/
j.neulet.2016.12.049.
• Mesev, et al., Mol Pharmacol. 2017
Jan 24. pii: mol.116.107169. doi:
10.1124/mol.116.107169.
• More, et al., J Cereb Blood Flow
Metab. 2016 May 18. pii:
0271678X16650216.
• Miller, et. al, Curr Pharm Des.
2014;20(10):1463–71. Review.
• Cartwright, et al., J Cereb Blood
Flow Metab. 2013 Mar;33(3):381–8. doi:
10.1038/jcbfm.2012.174.
Intellectual Property: HHS Reference
No. E–179–2065/0 and/1; U.S.
Provisional Patent Applications 62/
332,888 filed May 6, 2016, and 62/
453,718 filed February 2, 2017,
respectively.
Licensing Contact: Michael
Shmilovich, Esq., CLP; 301–435–5019;
shmilovm@mail.nih.gov.
Dated: February 10, 2017.
Michael Shmilovich,
Senior Licensing and Patenting Manager,
National Heart, Lung, and Blood Institute,
Office of Technology Transfer and
Development.
[FR Doc. 2017–03306 Filed 2–17–17; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Eunice Kennedy Shriver National
Institute of Child Health & Human
Development; Notice of Closed
Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
E:\FR\FM\21FEN1.SGM
21FEN1
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[Federal Register Volume 82, Number 33 (Tuesday, February 21, 2017)]
[Notices]
[Page 11235]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2017-03306]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government.
FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained
by emailing the indicated licensing contact at the National Heart,
Lung, and Blood, Office of Technology Transfer and Development Office
of Technology Transfer, 31 Center Drive, Room 4A29, MSC2479, Bethesda,
MD 20892-2479; telephone: 301-402-5579. A signed Confidential
Disclosure Agreement may be required to receive any unpublished
information.
SUPPLEMENTARY INFORMATION: The following inventions are available for
licensing in accordance with 35 U.S.C. 209 and 37 CFR part 404 to
achieve expeditious commercialization of results of federally-funded
research and development. Technology description follows.
Methods for Improving Drug Delivery to the Central Nervous System
The invention relates to the uses of the tricyclic antidepressant
amitriptyline, its bioactive metabolites, and other LPA1R activators to
improve the bioavailability and delivery of therapeutics to the central
nervous system. This invention demonstrates that amitriptyline and
other agents selectively decrease P-glycoprotein (P-gp) transport
activity by ligand activation of lysophosphatidic acid 1 receptor
(LPA1R) at the blood-brain barrier. P-gp is an effective target for
increasing drug delivery to the brain (CNS) for two major reasons: (1)
Its substrates include a large portion of on-the-market drugs,
including chemotherapeutics, and (2) its directionality results in a
net efflux of drugs from the brain. Additionally, specifically
targeting P-gp through LPA1R activation bypasses the clinical
challenges resulting from the toxicity of substrate inhibitors of P-gp.
This invention describes the inhibition of drug efflux by P-gp
transport; thus, co-administration of therapeutics with amitriptyline
and other LPA1R activators provides a method for increasing drug
delivery to the CNS, and improving overall drug efficacy. Moreover,
drug delivery to other barrier tissues will also be enhanced where a
similar LPA1R-P-gp activity relationship exists.
Potential Commercial Applications:
Drug Delivery to the CNS.
Co-administration of therapeutics.
Blood-brain-barrier permeability.
Development Stage:
Early stage.
Inventors: Ronald Cannon and David Banks (NIEHS).
Publications:
Cannon et al., Neurosci Lett. 2017 Feb 3;639:103-113 doi:
10.1016/j.neulet.2016.12.049.
Mesev, et al., Mol Pharmacol. 2017 Jan 24. pii:
mol.116.107169. doi: 10.1124/mol.116.107169.
More, et al., J Cereb Blood Flow Metab. 2016 May 18. pii:
0271678X16650216.
Miller, et. al, Curr Pharm Des. 2014;20(10):1463-71.
Review.
Cartwright, et al., J Cereb Blood Flow Metab. 2013
Mar;33(3):381-8. doi: 10.1038/jcbfm.2012.174.
Intellectual Property: HHS Reference No. E-179-2065/0 and/1; U.S.
Provisional Patent Applications 62/332,888 filed May 6, 2016, and 62/
453,718 filed February 2, 2017, respectively.
Licensing Contact: Michael Shmilovich, Esq., CLP; 301-435-5019;
shmilovm@mail.nih.gov.
Dated: February 10, 2017.
Michael Shmilovich,
Senior Licensing and Patenting Manager, National Heart, Lung, and Blood
Institute, Office of Technology Transfer and Development.
[FR Doc. 2017-03306 Filed 2-17-17; 8:45 am]
BILLING CODE 4140-01-P